CNOT1 and PPARG

Number of citations of the paper that reports this interaction (PMID 16778766)
20

Data Source:
HPRD (two hybrid)

		CNOT1	PPARG
Gene Name		CCR4-NOT transcription complex, subunit 1	peroxisome proliferator-activated receptor gamma
Image
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Extracellular Space Nucleoplasm Peroxisomal Membrane Cytosol Membrane CCR4-NOT Complex	Nucleus Nucleoplasm Cytosol Perinuclear Region Of Cytoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	Poly(A)-specific Ribonuclease Activity Protein Binding Protein Domain Specific Binding Estrogen Receptor Binding Protein Complex Scaffold Retinoic Acid Receptor Binding Poly(A) RNA Binding Armadillo Repeat Domain Binding	RNA Polymerase II Regulatory Region DNA Binding Core Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Prostaglandin Receptor Activity Protein Binding Drug Binding Zinc Ion Binding Enzyme Binding Protein Phosphatase Binding Estrogen Receptor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Activating Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Retinoid X Receptor Binding Arachidonic Acid Binding Alpha-actinin Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Transcription, DNA-templated Multicellular Organismal Development Gene Expression Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Negative Regulation Of Translation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gene Silencing By MiRNA Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Stem Cell Maintenance	Negative Regulation Of Transcription From RNA Polymerase II Promoter Placenta Development Negative Regulation Of Acute Inflammatory Response Transcription Initiation From RNA Polymerase II Promoter Lipid Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction G-protein Coupled Receptor Signaling Pathway Heart Development Response To Nutrient Regulation Of Blood Pressure Response To Cold Response To Mechanical Stimulus Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Receptor Biosynthetic Process Negative Regulation Of Cholesterol Storage Negative Regulation Of Sequestering Of Triglyceride Long-chain Fatty Acid Transport Fatty Acid Oxidation Monocyte Differentiation Negative Regulation Of Cell Growth Epithelial Cell Differentiation Response To Caffeine Organ Regeneration Response To Retinoic Acid Cellular Response To Insulin Stimulus Negative Regulation Of Collagen Biosynthetic Process Response To Vitamin A Response To Lipid Peroxisome Proliferator Activated Receptor Signaling Pathway Response To Immobilization Stress Response To Diuretic Glucose Homeostasis Response To Starvation Regulation Of Circadian Rhythm Lipoprotein Transport Steroid Hormone Mediated Signaling Pathway Response To Estrogen Innate Immune Response Cell Fate Commitment Positive Regulation Of Fat Cell Differentiation Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fatty Acid Oxidation Cell Maturation Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Oligodendrocyte Differentiation White Fat Cell Differentiation Brown Fat Cell Differentiation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Telomerase Activity Lipid Homeostasis Response To Low-density Lipoprotein Particle Positive Regulation Of Phagocytosis, Engulfment Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Cholesterol Transporter Activity Regulation Of Transcription Involved In Cell Fate Commitment Cellular Response To Lithium Ion Cellular Response To Retinoic Acid Cellular Response To Vitamin E Cellular Response To Prostaglandin E Stimulus Cellular Response To Hyperoxia Response To Metformin Negative Regulation Of Pancreatic Stellate Cell Proliferation
Pathways		Deadenylation of mRNA Deadenylation-dependent mRNA decay	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs			Icosapent Troglitazone Mesalazine Indomethacin Rosiglitazone Nateglinide Sulfasalazine Repaglinide Telmisartan Balsalazide Ibuprofen Glipizide Pioglitazone Mitiglinide Bezafibrate (S)-3-(4-(2-Carbazol-9-Yl-Ethoxy)-Phenyl)-2-Ethoxy-Propionic Acid 2-{5-[3-(6-BENZOYL-1-PROPYLNAPHTHALEN-2-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID (9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acid 2-{5-[3-(7-PROPYL-3-TRIFLUOROMETHYLBENZO[D]ISOXAZOL-6-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID (4S,5E,7Z,10Z,13Z,16Z,19Z)-4-hydroxydocosa-5,7,10,13,16,19-hexaenoic acid (5R,6E,8Z,11Z,14Z,17Z)-5-hydroxyicosa-6,8,11,14,17-pentaenoic acid (8E,10S,12Z)-10-hydroxy-6-oxooctadeca-8,12-dienoic acid (8R,9Z,12Z)-8-hydroxy-6-oxooctadeca-9,12-dienoic acid (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid difluoro(5-{2-[(5-octyl-1H-pyrrol-2-yl-kappaN)methylidene]-2H-pyrrol-5-yl-kappaN}pentanoato)boron (2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACID 3-(5-methoxy-1H-indol-3-yl)propanoic acid 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid (2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid 2-chloro-5-nitro-N-phenylbenzamide (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid 3-[5-(2-nitropent-1-en-1-yl)furan-2-yl]benzoic acid 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID (5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acid 3-FLUORO-N-[1-(4-FLUOROPHENYL)-3-(2-THIENYL)-1H-PYRAZOL-5-YL]BENZENESULFONAMIDE (2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid ALEGLITAZAR
Diseases
GWAS		QT interval ( 22726844 19305408)	Drug-induced liver injury ( 22968431) Fasting insulin-related traits (interaction with BMI) ( 22581228) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Type 2 diabetes ( 18372903 20581827 17463246 17463248 17463249)
Protein-Protein Interactions		8 interactors: CNOT2 CNOT3 CNOT4 CNOT8 PPARG RARA RXRA THRB	104 interactors: ALOX15B ANP32A APP BCAS2 BRD8 CDC34 CDK5 CEP350 CHD7 CNOT1 COPS5 CREBBP DNTTIP2 EDF1 EP300 ESR1 ESR2 FABP1 FHOD1 FOXO1 GADD45B GADD45G GRIP1 HDAC1 HDAC3 HDAC4 HELZ2 HMGA1 IKBKB JAZF1 JMJD1C JUN JUND KAT2A KAT5 KCTD13 KIF11 KIF1A LMO4 LRIF1 MAFF MAP2K1 MAPK1 MAPK8 MED1 MED24 MIF4GD MSX2 MUC1 NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NFE2L2 NFE2L3 NFKB1 NFKBIB NLK NR0B1 NR0B2 NR2E3 NR4A1 NR4A2 NRIP1 NSD1 PDIA2 PHB2 PML POU1F1 PPARGC1A PPM1B PRKCA RAD54L2 RANBP9 RB1 RELA ROBO4 RXRA RXRB RXRG SERPINH1 SETDB1 SFPQ SMARCD3 STAT6 SVIL SYT1 TFAP2A TNP1 TRIM24 TRIP4 UBC USP7 VDR ZBTB20 ZBTB3 ZBTB5 ZBTB9 ZNF496 ZNHIT3 ZSCAN1
Entrez ID		23019	5468
HPRD ID		11999	03288
Ensembl ID		ENSG00000125107	ENSG00000132170
Uniprot IDs		A5YKK6	D2KUA6 P37231
PDB IDs		4GMJ 4GML 4J8S	1FM6 1FM9 1I7I 1K74 1KNU 1NYX 1PRG 1RDT 1WM0 1ZEO 1ZGY 2ATH 2F4B 2FVJ 2G0G 2G0H 2GTK 2HFP 2HWQ 2HWR 2I4J 2I4P 2I4Z 2OM9 2P4Y 2POB 2PRG 2Q59 2Q5P 2Q5S 2Q61 2Q6R 2Q6S 2Q8S 2QMV 2VSR 2VST 2VV0 2VV1 2VV2 2VV3 2VV4 2XKW 2YFE 2ZK0 2ZK1 2ZK2 2ZK3 2ZK4 2ZK5 2ZK6 2ZNO 2ZVT 3ADS 3ADT 3ADU 3ADV 3ADW 3ADX 3AN3 3AN4 3B0Q 3B0R 3B1M 3B3K 3BC5 3CDP 3CDS 3CS8 3CWD 3D6D 3DZU 3DZY 3E00 3ET0 3ET3 3FEJ 3FUR 3G9E 3GBK 3H0A 3HO0 3HOD 3IA6 3K8S 3KMG 3LMP 3NOA 3OSI 3OSW 3PBA 3PO9 3PRG 3QT0 3R5N 3R8A 3R8I 3S9S 3SZ1 3T03 3TY0 3U9Q 3V9T 3V9V 3V9Y 3VJH 3VJI 3VN2 3VSO 3VSP 4A4V 4A4W 4E4K 4E4Q 4EM9 4EMA 4F9M 4FGY 4HEE 4PRG
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Poly(A) Tail Shortening Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA 3'-end Processing Regulation Of Translation Negative Regulation Of Gene Expression Steroid Hormone Mediated Signaling Pathway RNA 3'-end Processing Hormone-mediated Signaling Pathway Nuclear-transcribed MRNA Catabolic Process RNA Metabolic Process MRNA Catabolic Process Posttranscriptional Regulation Of Gene Expression Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Gene Expression RNA Catabolic Process Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Transcription, DNA-templated RNA Biosynthetic Process Gene Silencing By RNA Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Gene Silencing Cellular Response To Organic Cyclic Compound Cellular Response To Lipid MRNA Processing Response To Retinoic Acid Regulation Of Cellular Protein Metabolic Process Aromatic Compound Catabolic Process Nitrogen Compound Metabolic Process Response To Steroid Hormone Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Macromolecule Biosynthetic Process Epithelial Cell Differentiation MRNA Metabolic Process Regulation Of Stem Cell Maintenance Trophectodermal Cell Differentiation RNA Processing Cellular Response To Hormone Stimulus Response To Vitamin A	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Gene Expression RNA Metabolic Process Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Intracellular Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Intracellular Steroid Hormone Receptor Signaling Pathway Response To Organic Substance Cellular Metabolic Process Cellular Response To Organic Substance Chromatin Modification Chromatin Organization Response To Hormone Cellular Response To Hormone Stimulus Cellular Response To Lipid Response To Lipid Regulation Of Signaling
Tagcloud ?		accelerate cap ccr4 ddx6 deadenylase decapping decay disrupt effector eif4a eif4g exonucleolytic facilitates impair initiated micrornas mirisc mirna mirnas placing repress repressor resembling scaffolding shortening silencing subdomain tail widespread	abi1 atlas bitbucket ccnd3 ctnnd1 doi driver drivers dx fbln2 figshare hindered http https identifies implies isoform ktsp m9 mitf myh11 org prdm1 ralgds regulatorygenomicsupf signatures splicing switches transcript
Tagcloud (Difference) ?		accelerate cap ccr4 ddx6 deadenylase decapping decay disrupt effector eif4a eif4g exonucleolytic facilitates impair initiated micrornas mirisc mirna mirnas placing repress repressor resembling scaffolding shortening silencing subdomain tail widespread	abi1 atlas bitbucket ccnd3 ctnnd1 doi driver drivers dx fbln2 figshare hindered http https identifies implies isoform ktsp m9 mitf myh11 org prdm1 ralgds regulatorygenomicsupf signatures splicing switches transcript
Tagcloud (Intersection) ?