RAB37 and RAB5A

Number of citations of the paper that reports this interaction (PubMedID 10722846)
0

Data Source:
HPRD (two hybrid)

		RAB37	RAB5A
Description		RAB37, member RAS oncogene family	RAB5A, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Plasma Membrane Cilium Cytoplasmic Vesicle Photoreceptor Connecting Cilium Azurophil Granule Membrane Specific Granule Membrane Cell Projection	Ruffle Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Synaptic Vesicle Endosome Membrane Endomembrane System Actin Cytoskeleton Membrane Endocytic Vesicle Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Somatodendritic Compartment Melanosome Cell Projection Neuronal Cell Body Terminal Bouton Axon Terminus Membrane Raft Phagocytic Vesicle Extracellular Exosome Cytoplasmic Side Of Early Endosome Membrane
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Guanyl Nucleotide Binding GDP Binding
	Biological Process	Positive Regulation Of Autophagy Protein Transport Regulation Of Exocytosis Regulation Of Eye Photoreceptor Cell Development	Intracellular Protein Transport Endocytosis Phagocytosis Protein Transport Endosomal Transport Receptor Internalization Synaptic Vesicle Recycling Host-mediated Perturbation Of Viral Process Early Endosome To Late Endosome Transport Positive Regulation Of Exocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Plasma Membrane To Endosome Transport Regulation Of Endosome Size Regulation Of Filopodium Assembly Canonical Wnt Signaling Pathway Membrane Fusion Amyloid-beta Clearance By Transcytosis Protein Localization To Early Endosome Regulation Of Synaptic Vesicle Exocytosis Regulation Of Autophagosome Assembly
Pathways		Neutrophil degranulation RAB geranylgeranylation	Synthesis of PIPs at the plasma membrane TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Prevention of phagosomal-lysosomal fusion Respiratory syncytial virus (RSV) attachment and entry Factors involved in megakaryocyte development and platelet production
Drugs			L-methionine (S)-S-oxide Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		C-reactive protein levels ( 30388399) Coronary artery disease ( 29212778) Fibrinogen levels ( 28107422) Granulocyte count ( 27863252) Liver fibrosis in pediatric non-alcoholic fatty acid liver disease ( 28918882) Monocyte count ( 27863252 32888494) Myeloid white cell count ( 27863252) Neurological blood protein biomarker levels ( 31320639) Neutrophil count ( 27863252) Platelet count ( 32888494) Plateletcrit ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494)	Heel bone mineral density ( 30598549) Iris color (L* coordinate) ( 30895295)
Interacting Genes		5 interacting genes: EWSR1 MAL2 RAB5A RABGGTB RIMS1	37 interacting genes: AGTR1 ALS2CL ANKFY1 APPL1 APPL2 CHML EEA1 GDI2 GRIK4 HTATIP2 ITSN1 NME2 OCRL RAB37 RABAC1 RABEP1 RABEP2 RABGGTB RASA1 RBSN RIN1 RIN2 RIN3 RIT2 RUFY1 SDCBP SGSM3 SNCA STX4 TBC1D15 TBC1D17 TBC1D3C TBC1D3F TRIM14 TSC2 USP6NL WEE2-AS1
Entrez ID		326624	5868
HPRD ID		06702	01542
Ensembl ID		ENSG00000172794	ENSG00000144566
Uniprot IDs		A0A9H3ZVF6 B3KPZ5 B7Z3L0 Q96AX2	P20339
PDB IDs			1N6H 1N6I 1N6K 1N6L 1N6N 1N6O 1N6P 1N6R 1R2Q 1TU3 1TU4 3MJH 4Q9U 7BL1
Enriched GO Terms of Interacting Partners?		Regulation Of Synaptic Vesicle Exocytosis Plasma Membrane Cytoplasmic Side Of Early Endosome Membrane Regulation Of Exocytosis Membrane Raft Regulation Of Neurotransmitter Secretion Protein Localization To Early Endosome Membrane Fusion Regulation Of Regulated Secretory Pathway Visual Perception Rab-protein Geranylgeranyltransferase Complex Protein Prenyltransferase Activity Sensory Perception Of Light Stimulus Rab Geranylgeranyltransferase Activity Protein Geranylgeranyltransferase Activity Acrosomal Vesicle Exocytosis Plasma Membrane To Endosome Transport Endomembrane System Vesicle-mediated Transport Intracellular Transport Amyloid-beta Clearance By Transcytosis Protein Geranylgeranylation Small GTPase Binding Prenyltransferase Activity Protein Prenylation Structural Constituent Of Presynaptic Active Zone Modulation Of Inhibitory Postsynaptic Potential Maintenance Of Presynaptic Active Zone Structure Presynaptic Active Zone Organization Positive Regulation Of Inhibitory Postsynaptic Potential Structural Constituent Of Myelin Sheath Regulation Of Endosome Size Early Phagosome Synaptic Vesicle Docking Presynaptic Active Zone Cytoplasmic Component Protein Localization To Endosome Synaptic Vesicle Recycling Somatodendritic Compartment Guanyl Nucleotide Binding Synaptic Vesicle Priming Regulation Of Vesicle Size Transcytosis Positive Regulation Of Dendrite Extension Cellular Localization Establishment Of Localization In Cell Early Endosome To Late Endosome Transport Amyloid-beta Clearance Regulation Of Long-term Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Sensory Perception	GTPase Activator Activity Small GTPase Binding Vesicle-mediated Transport Endosome Regulation Of Endocytosis Regulation Of Vesicle-mediated Transport Endocytosis Cytoplasmic Vesicle Regulation Of Cellular Component Organization Cellular Localization Import Into Cell Intracellular Transport Regulation Of Cilium Assembly Endosomal Transport Small GTPase-mediated Signal Transduction Macropinosome Establishment Of Protein Localization Protein Transport Early Endosome Membrane Cytosol Establishment Of Localization In Cell Positive Regulation Of Pinocytosis Regulation Of Transport Early Endosome Regulation Of Organelle Assembly Cytoplasm Positive Regulation Of Macropinocytosis Regulation Of Cell Projection Assembly Endocytic Vesicle Membrane Fusion Positive Regulation Of Endocytosis Rab-protein Geranylgeranyltransferase Complex Phagocytic Vesicle Signal Transduction Intracellular Protein Localization Vesicle Fusion Retrograde Transport, Endosome To Golgi Protein Geranylgeranylation Organelle Membrane Fusion Ruffle Guanyl-nucleotide Exchange Factor Activity Synapse Adiponectin-activated Signaling Pathway Regulation Of Organelle Organization Protein Prenylation Organelle Fusion Cytosolic Transport Plasma Membrane To Endosome Transport Recycling Endosome Cell Projection
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