SEPHS2 and ARHGEF5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SEPHS2	ARHGEF5
Gene Name		selenophosphate synthetase 2	Rho guanine nucleotide exchange factor (GEF) 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component
	Molecular Function	Selenide, Water Dikinase Activity ATP Binding	Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding
	Biological Process	Selenocysteine Biosynthetic Process Phosphorylation	Myeloid Dendritic Cell Chemotaxis Actin Cytoskeleton Organization Regulation Of Rho GTPase Activity Positive Regulation Of Rho GTPase Activity Intracellular Signal Transduction Positive Regulation Of Podosome Assembly
Pathways
Drugs
Diseases
GWAS			Breast cancer ( 23535729)
Protein-Protein Interactions		1 interactors: ARHGEF5	15 interactors: APP ATP13A1 CALCOCO2 CCNE1 CHPF CRKL EFHC2 FKBP8 GRB2 HSPBAP1 NR4A1 PLCG1 SEPHS2 TRIM27 TRIM54
Entrez ID		22928	7984
HPRD ID		12096	02932
Ensembl ID		ENSG00000179918	ENSG00000050327
Uniprot IDs		F5H8F9 Q99611	Q12774
PDB IDs
Enriched GO Terms of Interacting Partners?		Myeloid Dendritic Cell Chemotaxis Positive Regulation Of Podosome Assembly Regulation Of Podosome Assembly Dendritic Cell Chemotaxis Positive Regulation Of Organelle Assembly Dendritic Cell Migration Leukocyte Chemotaxis Cell Chemotaxis Positive Regulation Of Protein Complex Assembly Leukocyte Migration Positive Regulation Of Rho GTPase Activity	Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Protein Kinase Activity Immune Response Regulation Of Phosphorylation Defense Response Regulation Of Kinase Activity Immune System Process Regulation Of Phosphorus Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Intracellular Receptor Signaling Pathway Viral Process Regulation Of Protein Phosphorylation Cellular Response To Growth Factor Stimulus Fc-epsilon Receptor Signaling Pathway Chemotaxis Response To Growth Factor Regulation Of Cellular Protein Metabolic Process Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Selenocysteine Biosynthetic Process Activation Of MAPKK Activity Signaling Cell Communication Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of ERBB Signaling Pathway Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Stress Enzyme Linked Receptor Protein Signaling Pathway Axon Guidance Negative Regulation Of Interleukin-2 Secretion Synaptic Growth At Neuromuscular Junction Selenium Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Blood Coagulation Hemostasis Positive Regulation Of Actin Filament Polymerization Collateral Sprouting In Absence Of Injury Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Polymerization
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