SEPHS2 and SCLY

Number of citations of the paper that reports this interaction (PubMedID 39547224)
0

Data Source:
BioGRID (pull down)

		SEPHS2	SCLY
Description		selenophosphate synthetase 2	selenocysteine lyase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Golgi Apparatus Cytosol Catalytic Complex
	Molecular Function	Nucleotide Binding Selenide, Water Dikinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding	Protein Binding Selenocysteine Lyase Activity Amino Acid Binding Transferase Activity Lyase Activity Protein Homodimerization Activity Vitamin B6 Binding
	Biological Process	Selenium Compound Metabolic Process Selenocysteine Metabolic Process Selenocysteine Biosynthetic Process	Amino Acid Metabolic Process Selenocysteine Catabolic Process
Pathways		Selenocysteine synthesis	Metabolism of ingested SeMet, Sec, MeSec into H2Se
Drugs			Pyridoxal phosphate Pyridoxal phosphate
Diseases
GWAS		Eosinophil count ( 32888494)
Interacting Genes		3 interacting genes: ARHGEF5 PRDX6 SCLY	5 interacting genes: CREB3 LNX2 OGT SEPHS2 TERF2IP
Entrez ID		22928	51540
HPRD ID		12096	15303
Ensembl ID		ENSG00000179918	ENSG00000132330
Uniprot IDs		Q99611	A0A0A0MQU4 B4DDP9 Q59FK2 Q96I15
PDB IDs			3GZC 3GZD
Enriched GO Terms of Interacting Partners?		Selenocysteine Lyase Activity Vitamin B6 Binding Selenocysteine Catabolic Process Positive Regulation Of Protein Import Myeloid Dendritic Cell Chemotaxis Regulation Of Protein Import Selenocysteine Metabolic Process 1-acylglycerophosphocholine O-acyltransferase Activity Peroxiredoxin Activity Calcium-independent Phospholipase A2 Activity Positive Regulation Of Podosome Assembly Regulation Of Podosome Assembly Positive Regulation Of JUN Kinase Activity Amino Acid Binding Dendritic Cell Migration Hematopoietic Stem Cell Homeostasis Dendritic Cell Chemotaxis Glutathione Peroxidase Activity Phospholipase A2 Activity Hydrogen Peroxide Catabolic Process Peroxidase Activity Antioxidant Activity Hydrogen Peroxide Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Glycerophospholipid Catabolic Process Serine Family Amino Acid Metabolic Process Catalytic Complex Positive Regulation Of MAP Kinase Activity Podosome Phospholipid Catabolic Process Positive Regulation Of RNA Splicing Cell Redox Homeostasis	Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Deacetylase Activity Selenocysteine Biosynthetic Process Selenide, Water Dikinase Activity Selenium Compound Metabolic Process Negative Regulation Of DNA Recombination At Telomere Protein O-acetylglucosaminyltransferase Activity Selenocysteine Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose CCR1 Chemokine Receptor Binding Release From Viral Latency Protection From Non-homologous End Joining At Telomere Shelterin Complex Regulation Of Transcription By Glucose Nuclear Telomere Cap Complex CAMP Response Element Binding Protein Binding G-rich Strand Telomeric DNA Binding NSL Complex Protein Localization To Chromosome, Telomeric Region
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