PLEKHA6 and PLEKHA5

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		PLEKHA6	PLEKHA5
Description		pleckstrin homology domain containing A6	pleckstrin homology domain containing A5
Image
GO Annotations	Cellular Component		Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding	Protein Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process		Reproductive System Development
Pathways		Synthesis of PIPs at the plasma membrane	Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lymphocyte count ( 32888494) Monocyte count ( 32888494) Palmitoleic acid (16:1n-7) levels ( 23362303) Platelet count ( 32888494) Plateletcrit ( 27863252 32888494) Prostate cancer ( 23535732) Red blood cell count ( 32888494) Regular attendance at a religious group ( 29970889) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Spleen volume ( 34128465) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Chronic mountain sickness ( 31417607) Daytime sleep phenotypes ( 27126917) Gut microbiota (bacterial taxa) ( 27694959) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Pharmacokinetics of antiepileptic drugs in severe mental disorder (concentration drug ratio) ( 25944848) Platelet reactivity in response to clopidogrel treatment ( 32472697) Thalamus volume ( 31530798)
Interacting Genes		3 interacting genes: APOE PLEKHA5 UBE2Z	30 interacting genes: ARHGEF9 BLOC1S6 CCDC186 CCDC88B CCDC92 CEP250 CEP350 DES EVPL EXTL3 KANSL1 KIF3A KRT19 KRT20 KTN1 LAMB2 LSM4 MAX MTCL2 PLEC PLEKHA6 PPP1R13B PROM1 SH3BP5L SPTAN1 SPTBN1 SRPK2 UPF1 WASH2P YWHAG
Entrez ID		22874	54477
HPRD ID		09685	09684
Ensembl ID		ENSG00000143850	ENSG00000052126
Uniprot IDs		Q9Y2H5	A0A8V8TQ09 A0A8V8TQJ8 A0A9L9PX43 Q9HAU0
PDB IDs		2D9Y 2YRY	2DKP
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Phospholipid Efflux Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Lipid Transport Involved In Lipid Storage Lipoprotein Particle Positive Regulation Of Neurofibrillary Tangle Assembly Discoidal High-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipoprotein Transport Negative Regulation Of Dendritic Spine Maintenance Very-low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Very-low-density Lipoprotein Particle Clearance Multivesicular Body, Internal Vesicle Positive Regulation Of Phospholipid Efflux Positive Regulation Of Amyloid Fibril Formation AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Positive Regulation Of Inclusion Body Assembly Triglyceride-rich Lipoprotein Particle Clearance Positive Regulation Of Dendritic Spine Maintenance Regulation Of Plasma Lipoprotein Particle Levels Chylomicron Remnant Clearance Regulation Of Neurofibrillary Tangle Assembly Lipoprotein Biosynthetic Process Phosphatidylcholine-sterol O-acyltransferase Activator Activity Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Lipoprotein Particle Binding Virion Assembly Very-low-density Lipoprotein Particle Remodeling Positive Regulation Of Amyloid-beta Clearance Cholesterol Catabolic Process Negative Regulation Of Cholesterol Biosynthetic Process Protein Import High-density Lipoprotein Particle Clearance Negative Regulation Of Cholesterol Metabolic Process Nitric Oxide-cGMP-mediated Signaling Negative Regulation Of Dendritic Spine Development Positive Regulation Of Receptor Catabolic Process Triglyceride-rich Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly Response To Caloric Restriction Regulation Of Behavioral Fear Response	Structural Constituent Of Cytoskeleton Cytoskeleton Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Organelle Organization Intermediate Filament Cytoskeleton Cytoskeleton Organization Double-stranded DNA Helicase Activity Intermediate Filament Organization Intermediate Filament Cadherin Binding Supramolecular Fiber Organization Extracellular Exosome Spectrin Vesicle Cytoskeletal Trafficking Contractile Muscle Fiber Centriole-centriole Cohesion Centriole Cytoskeletal Protein Binding Costamere Structural Molecule Activity Intracellular Protein Localization Ankyrin Binding Cytoskeleton-dependent Intracellular Transport Actin Cytoskeleton Organization Actin Filament Binding Purine Nucleoside Metabolic Process Epithelial Cell Differentiation Microtubule Anchoring Protein Localization To Centrosome Establishment Of Vesicle Localization Actin Filament-based Process Cytosol DATP Biosynthetic Process Adenosine Kinase Activity Membrane Organization Sarcolemma Metanephric Glomerular Basement Membrane Development MLL1 Complex Microtubule Binding Cilium Assembly Vesicle Localization Bradykinin Biosynthetic Process Circadian Sleep/wake Cycle Actin Filament Capping Establishment Of Organelle Localization Regulation Of Protein-containing Complex Disassembly
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