PLEKHA6

Gene Name		pleckstrin homology domain containing, family A member 6
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Gene Ontology Annotations	Cellular Component
	Molecular Function
	Biological Process
Pathways
Drugs
Diseases
GWAS		Palmitoleic acid (16:1n-7) plasma levels ( 23362303) Prostate cancer ( 23535732)
Protein-protein Interactions		2 interactors: APOE PLEKHA5
Entrez ID		22874
HPRD ID		09685
Ensembl ID		ENSG00000143850
Uniprot IDs		Q9Y2H5
PDB IDs		2D9Y 2YRY
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Presynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Positive Regulation Of Phospholipid Efflux Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Postsynaptic Membrane Organization Very-low-density Lipoprotein Particle Clearance Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Cholesterol Efflux N-methyl-D-aspartate Receptor Clustering Regulation Of Tau-protein Kinase Activity Regulation Of Presynaptic Membrane Organization Negative Regulation Of Dendritic Spine Development High-density Lipoprotein Particle Clearance Positive Regulation Of Inclusion Body Assembly Regulation Of Beta-amyloid Clearance Very-low-density Lipoprotein Particle Remodeling Positive Regulation Of Cholesterol Esterification Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering High-density Lipoprotein Particle Assembly Positive Regulation Of Phospholipid Transport Chylomicron Remnant Clearance Regulation Of Cholesterol Esterification Peripheral Nervous System Axon Regeneration Triglyceride-rich Lipoprotein Particle Remodeling Negative Regulation Of Beta-amyloid Formation CGMP-mediated Signaling Low-density Lipoprotein Particle Remodeling Cholesterol Catabolic Process Negative Regulation Of Cholesterol Transport Phospholipid Efflux Synaptic Transmission, Cholinergic Positive Regulation Of Beta-amyloid Formation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Cellular Response To Cholesterol Negative Regulation Of Amyloid Precursor Protein Catabolic Process Fatty Acid Homeostasis Lipoprotein Catabolic Process Negative Regulation Of Dendrite Development Response To Dietary Excess Cellular Response To Sterol Nitric Oxide Mediated Signal Transduction
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