PLEKHA6

Description		pleckstrin homology domain containing A6
Image
GO Annotations	Cellular Component
	Molecular Function	Protein Binding
	Biological Process
Pathways		Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lymphocyte count ( 32888494) Monocyte count ( 32888494) Palmitoleic acid (16:1n-7) levels ( 23362303) Platelet count ( 32888494) Plateletcrit ( 27863252 32888494) Prostate cancer ( 23535732) Red blood cell count ( 32888494) Regular attendance at a religious group ( 29970889) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Spleen volume ( 34128465) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429)
Interacting Genes		3 interacting genes: APOE PLEKHA5 UBE2Z
Entrez ID		22874
HPRD ID		09685
Ensembl ID		ENSG00000143850
Uniprot IDs		Q9Y2H5
PDB IDs		2D9Y 2YRY
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Phospholipid Efflux Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Lipid Transport Involved In Lipid Storage Lipoprotein Particle Positive Regulation Of Neurofibrillary Tangle Assembly Discoidal High-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipoprotein Transport Negative Regulation Of Dendritic Spine Maintenance Very-low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Very-low-density Lipoprotein Particle Clearance Multivesicular Body, Internal Vesicle Positive Regulation Of Phospholipid Efflux Positive Regulation Of Amyloid Fibril Formation AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Positive Regulation Of Inclusion Body Assembly Triglyceride-rich Lipoprotein Particle Clearance Positive Regulation Of Dendritic Spine Maintenance Regulation Of Plasma Lipoprotein Particle Levels Chylomicron Remnant Clearance Regulation Of Neurofibrillary Tangle Assembly Lipoprotein Biosynthetic Process Phosphatidylcholine-sterol O-acyltransferase Activator Activity Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Lipoprotein Particle Binding Virion Assembly Very-low-density Lipoprotein Particle Remodeling Positive Regulation Of Amyloid-beta Clearance Cholesterol Catabolic Process Negative Regulation Of Cholesterol Biosynthetic Process Protein Import High-density Lipoprotein Particle Clearance Negative Regulation Of Cholesterol Metabolic Process Nitric Oxide-cGMP-mediated Signaling Negative Regulation Of Dendritic Spine Development Positive Regulation Of Receptor Catabolic Process Triglyceride-rich Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly Response To Caloric Restriction Regulation Of Behavioral Fear Response
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