MOCS3 and EXOSC6

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		MOCS3	EXOSC6
Description		molybdenum cofactor synthesis 3	exosome component 6
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex)
	Molecular Function	Nucleotide Binding Catalytic Activity Thiosulfate-cyanide Sulfurtransferase Activity Protein Binding ATP Binding Ubiquitin-like Modifier Activating Enzyme Activity Transferase Activity Nucleotidyltransferase Activity Sulfurtransferase Activity URM1 Activating Enzyme Activity Metal Ion Binding Molybdopterin-synthase Sulfurtransferase Activity Molybdopterin-synthase Adenylyltransferase Activity Adenylyltransferase Activity	RNA Binding RNA Exonuclease Activity
	Biological Process	TRNA Wobble Uridine Modification TRNA Wobble Position Uridine Thiolation Mo-molybdopterin Cofactor Biosynthetic Process TRNA Processing Protein Urmylation TRNA Thio-modification	DNA Metabolic Process RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process U4 SnRNA 3'-end Processing DNA Deamination Isotype Switching Positive Regulation Of Isotype Switching Nuclear MRNA Surveillance Poly(A)-dependent SnoRNA 3'-end Processing
Pathways		Molybdenum cofactor biosynthesis	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)	Brain morphology (MOSTest) ( 32665545) Malaria ( 31844061)
Interacting Genes		3 interacting genes: EXOSC6 MOCS2 XRN2	34 interacting genes: C1QBP CHPF DCP1B DIS3 DNAJC30 EIF3I ESRRA EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 GSE1 LSM1 LSM7 LSM8 MAN2C1 MIF4GD MOCS3 MRPL4 MRPS18B MTREX NDUFA13 NUDT21 PALS2 PSMB1 RAB3GAP2 SRSF3 TUFM UPF2 XRN1 ZFP36
Entrez ID		27304	118460
HPRD ID		10092	12107
Ensembl ID		ENSG00000124217	ENSG00000223496
Uniprot IDs		O95396	Q5RKV6
PDB IDs		3I2V	2NN6 6D6Q 6D6R 6H25 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		Molybdopterin Cofactor Metabolic Process Mo-molybdopterin Cofactor Biosynthetic Process Molybdopterin Synthase Activity Molybdopterin Synthase Complex Molybdopterin Cofactor Biosynthetic Process MRNA Catabolic Process Transcription Termination Site Sequence-specific DNA Binding RRNA Processing Nuclear-transcribed MRNA Catabolic Process RNA Catabolic Process 5'-3' RNA Exonuclease Activity RRNA Metabolic Process Regulation Of Golgi Lumen Acidification Termination Of RNA Polymerase II Transcription Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Nucleobase-containing Compound Catabolic Process 5'-3' Exonuclease Activity Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity Nuclear MRNA Surveillance DNA Deamination Nucleolar Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity RRNA Catabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Sno(s)RNA Metabolic Process Male Gamete Generation Spermatogenesis DNA-templated Transcription Termination SnRNA 3'-end Processing Gamete Generation Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Multivesicular Body Membrane Positive Regulation Of Isotype Switching Somatic Diversification Of Immunoglobulins Involved In Immune Response DNA Modification 3'-5'-RNA Exonuclease Activity MRNA Metabolic Process Acrosome Assembly Aggresome SnRNA Processing Somatic Recombination Of Immunoglobulin Gene Segments Nuclear RNA Surveillance Regulation Of Isotype Switching RNA Surveillance Positive Regulation Of Immunoglobulin Mediated Immune Response	Exosome (RNase Complex) RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Nuclear Exosome (RNase Complex) Nuclear MRNA Surveillance MRNA Metabolic Process Cytoplasmic Exosome (RNase Complex) Nucleobase-containing Compound Catabolic Process Nucleolar Exosome (RNase Complex) Nuclear RNA Surveillance RNA Surveillance RNA Exonuclease Activity RRNA Catabolic Process U4 SnRNA 3'-end Processing RNA Binding RNA Metabolic Process SnRNA Metabolic Process 3'-5'-RNA Exonuclease Activity Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process RNA Processing Macromolecule Catabolic Process SnRNA 3'-end Processing RNA 3'-end Processing RRNA 3'-end Processing TRNA Decay MRNA 3'-UTR AU-rich Region Binding RRNA Metabolic Process SnRNA Processing Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process RRNA Processing Catabolic Process Macromolecule Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Negative Regulation Of Gene Expression U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Histone MRNA Catabolic Process Sno(s)RNA Metabolic Process CUT Catabolic Process Histone MRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MRNA Binding Nucleolus
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