PGGT1B and GNG2

Number of citations of the paper that reports this interaction (PMID 15451670)
58

Data Source:
HPRD (in vitro)

		PGGT1B	GNG2
Gene Name		protein geranylgeranyltransferase type I, beta subunit	guanine nucleotide binding protein (G protein), gamma 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	CAAX-protein Geranylgeranyltransferase Complex	Heterotrimeric G-protein Complex Plasma Membrane Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Activity Drug Binding Zinc Ion Binding Isoprenoid Binding Peptide Binding	Signal Transducer Activity G-protein Beta-subunit Binding
	Biological Process	Positive Regulation Of Cell Proliferation Protein Geranylgeranylation Response To Cytokine Positive Regulation Of Cell Cycle Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process	Energy Reserve Metabolic Process Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Synaptic Transmission Blood Coagulation Cell Proliferation Platelet Activation Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Catecholamine Stimulus
Pathways			Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation
Drugs		4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE GERANYLGERANYL DIPHOSPHATE 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE	Halothane
Diseases
GWAS			Non-melanoma skin cancer ( 23548203)
Protein-Protein Interactions		5 interactors: CDC42 GNG2 KRAS RHOB RRAS2	15 interactors: ADRA2A ADRB2 AVPR2 BTK CACNA1H CHRM2 GNB1 GNB3 GNB4 GNB5 MRGPRX1 PGGT1B PLEKHG2 SMURF2 TBXA2R
Entrez ID		5229	54331
HPRD ID		03612	16234
Ensembl ID		ENSG00000164219	ENSG00000186469
Uniprot IDs		P53609	P59768
PDB IDs			4KFM
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Small GTPase Mediated Signal Transduction Response To Wounding Ras Protein Signal Transduction Regulation Of Neuron Death Axon Guidance Regulation Of Cell Death Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Vascular Endothelial Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Small GTPase Mediated Signal Transduction Neuron Projection Development Positive Regulation Of Hair Follicle Cell Proliferation Cell Projection Morphogenesis Cell Part Morphogenesis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Signal Transduction Actin Filament Branching Submandibular Salivary Gland Formation Neuron Development Platelet Activation Signaling Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Cell Morphogenesis Cell Communication Leukocyte Migration Positive Regulation Of Rac Protein Signal Transduction Regulation Of Neuron Apoptotic Process Neuron Differentiation Cell Projection Organization Establishment Of Golgi Localization Fc Receptor Signaling Pathway Transformed Cell Apoptotic Process Positive Regulation Of Metalloenzyme Activity Locomotion Cellular Response To Peptide Hormone Stimulus Neuron Fate Determination Epithelial-mesenchymal Cell Signaling Cellular Response To Stimulus Muscle Cell Differentiation	G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Organic Substance G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Response To Stimulus Cellular Response To Stimulus Signal Transduction Signaling Cell Communication Cellular Response To Hormone Stimulus Energy Reserve Metabolic Process Cellular Response To Glucagon Stimulus Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Blood Pressure Regulation Of Smooth Muscle Contraction Response To Glucagon Cellular Response To Organic Substance Regulation Of Adenylate Cyclase Activity Regulation Of Vasoconstriction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Cyclase Activity Response To Hormone Regulation Of CAMP Biosynthetic Process Energy Derivation By Oxidation Of Organic Compounds Regulation Of CAMP Metabolic Process Regulation Of Cellular Process Blood Circulation G-protein Coupled Acetylcholine Receptor Signaling Pathway Negative Regulation Of Smooth Muscle Contraction Adrenergic Receptor Signaling Pathway Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Response To External Stimulus Negative Regulation Of Muscle Contraction Generation Of Precursor Metabolites And Energy Homeostatic Process Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Hemostasis Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Muscle Contraction Chemical Homeostasis Activation Of Adenylate Cyclase Activity Rhodopsin Mediated Signaling Pathway Cytosolic Calcium Ion Homeostasis Positive Regulation Of Vasoconstriction Response To Peptide Platelet Activation Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Blood Pressure
Tagcloud ?			abcc4 abcc5 all97 atp6ap2 caucasian childhood cytotoxicity frmd4b genotyped impdh1 itpa kcnma1 lymphoblastic lymphoblastoid mercaptopurine nme1 outside shifts slc28a3 snp snps tagsnps thioguanine thiopurine thiopurines top uk validation xdh
Tagcloud (Difference) ?			abcc4 abcc5 all97 atp6ap2 caucasian childhood cytotoxicity frmd4b genotyped impdh1 itpa kcnma1 lymphoblastic lymphoblastoid mercaptopurine nme1 outside shifts slc28a3 snp snps tagsnps thioguanine thiopurine thiopurines top uk validation xdh
Tagcloud (Intersection) ?