PGGT1B and RHOB

Number of citations of the paper that reports this interaction (PMID 1400319)
59

Data Source:
HPRD (in vitro)

		PGGT1B	RHOB
Gene Name		protein geranylgeranyltransferase type I, beta subunit	ras homolog family member B
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	CAAX-protein Geranylgeranyltransferase Complex	Nucleus Early Endosome Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Late Endosome Membrane Cleavage Furrow Extracellular Vesicular Exosome
	Molecular Function	Protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Activity Drug Binding Zinc Ion Binding Isoprenoid Binding Peptide Binding	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Positive Regulation Of Cell Proliferation Protein Geranylgeranylation Response To Cytokine Positive Regulation Of Cell Cycle Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process	Cytokinesis Angiogenesis Intracellular Protein Transport Apoptotic Process Transformed Cell Apoptotic Process Cell Adhesion Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Axon Guidance Blood Coagulation Metabolic Process Endosome To Lysosome Transport Platelet Activation Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Regulation Of Small GTPase Mediated Signal Transduction Cellular Response To Hydrogen Peroxide Cellular Response To Ionizing Radiation
Pathways			Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Axon guidance Semaphorin interactions Signaling by Rho GTPases GPVI-mediated activation cascade G alpha (12/13) signalling events Sema4D in semaphorin signaling Platelet activation, signaling and aggregation Sema4D induced cell migration and growth-cone collapse
Drugs		4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE GERANYLGERANYL DIPHOSPHATE 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE
Diseases
GWAS			Systemic sclerosis ( 21750679)
Protein-Protein Interactions		5 interactors: CDC42 GNG2 KRAS RHOB RRAS2	9 interactors: ARHGDIG ARHGEF3 CIT FNTA PDE6D PGGT1B PPP2CA RHPN2 TNFAIP1
Entrez ID		5229	388
HPRD ID		03612	01321
Ensembl ID		ENSG00000164219	ENSG00000143878
Uniprot IDs		P53609	P62745
PDB IDs			2FV8
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Small GTPase Mediated Signal Transduction Response To Wounding Ras Protein Signal Transduction Regulation Of Neuron Death Axon Guidance Regulation Of Cell Death Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Vascular Endothelial Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Small GTPase Mediated Signal Transduction Neuron Projection Development Positive Regulation Of Hair Follicle Cell Proliferation Cell Projection Morphogenesis Cell Part Morphogenesis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Signal Transduction Actin Filament Branching Submandibular Salivary Gland Formation Neuron Development Platelet Activation Signaling Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Cell Morphogenesis Cell Communication Leukocyte Migration Positive Regulation Of Rac Protein Signal Transduction Regulation Of Neuron Apoptotic Process Neuron Differentiation Cell Projection Organization Establishment Of Golgi Localization Fc Receptor Signaling Pathway Transformed Cell Apoptotic Process Positive Regulation Of Metalloenzyme Activity Locomotion Cellular Response To Peptide Hormone Stimulus Neuron Fate Determination Epithelial-mesenchymal Cell Signaling Cellular Response To Stimulus Muscle Cell Differentiation	Protein Geranylgeranylation Protein Prenylation Regulation Of Catalytic Activity Response To Stimulus Rho Protein Signal Transduction Apoptotic Process Programmed Cell Death Positive Regulation Of Tubulin Deacetylation Cell Death Death Regulation Of Metabolic Process Negative Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Receptor Activity Regulation Of DNA Replication Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Protein Farnesylation Positive Regulation Of Catalytic Activity Regulation Of Signal Transduction Regulation Of Tubulin Deacetylation Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Deacetylase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Intracellular Signal Transduction Neurotransmitter Receptor Metabolic Process Regulation Of Signaling Ras Protein Signal Transduction Metaphase/anaphase Transition Of Mitotic Cell Cycle Negative Regulation Of Dendrite Morphogenesis Cellular Macromolecule Catabolic Process Intracellular Signal Transduction Cellular Protein Modification Process Mitotic Nuclear Envelope Reassembly Enzyme Linked Receptor Protein Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Heterotrimerization Nuclear Envelope Reassembly Positive Regulation Of Metabolic Process Positive Regulation Of Cell Cycle Signal Transduction Stress Fiber Assembly Positive Regulation Of Hydrolase Activity Negative Regulation Of Dendrite Development Regulation Of Rho Protein Signal Transduction Negative Regulation Of Cell Development Signaling Negative Regulation Of Epithelial To Mesenchymal Transition Cell Communication
Tagcloud ?			addiction belongs compromised cytoskeletal epilepsy glioblastoma glioma gtpase homologs inversely limiting nononcogene p21cip1 phenotypes retaining rhoa rhoc scarcity spheroid stat3 trafficking tumorigenic v14 vast vesicle waf1 xenograft xenografts
Tagcloud (Difference) ?			addiction belongs compromised cytoskeletal epilepsy glioblastoma glioma gtpase homologs inversely limiting nononcogene p21cip1 phenotypes retaining rhoa rhoc scarcity spheroid stat3 trafficking tumorigenic v14 vast vesicle waf1 xenograft xenografts
Tagcloud (Intersection) ?