PGGT1B and RHOB

Number of citations: 0 (PubMedID 15451670)
Data Source: HPRD (in vitro)

		PGGT1B	RHOB
Name		protein geranylgeranyltransferase type I subunit beta	ras homolog family member B
Structure		No pdb structure
GO Annotations	Cellular Component	CAAX-protein Geranylgeranyltransferase Complex	Nucleus Endosome Early Endosome Late Endosome Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Membrane Late Endosome Membrane Cleavage Furrow Synapse Extracellular Exosome Schaffer Collateral - CA1 Synapse
	Molecular Function	Catalytic Activity Prenyltransferase Activity Protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Activity Protein Binding Zinc Ion Binding Protein Prenyltransferase Activity Transferase Activity Metal Ion Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Protein Geranylgeranylation	Mitotic Cytokinesis Angiogenesis Intracellular Protein Transport Apoptotic Process Actin Filament Organization Cell Adhesion Signal Transduction Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Endosome To Lysosome Transport Positive Regulation Of Endothelial Cell Migration Protein Transport Cell Differentiation Regulation Of Cell Migration Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Endothelial Tube Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Ionizing Radiation Regulation Of Modification Of Postsynaptic Structure
Pathways		None	GPVI-mediated activation cascade G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins RHOB GTPase cycle
Drugs		L-778123 Geranylgeranyl diphosphate 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE	Botulinum toxin type A
GWAS		Longevity ( 30294719 )	Systemic sclerosis ( 21750679 ) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683 )
Novel Interactors		None recorded	2 novel interactors: ADORA2A SNX17
Interacting Genes		6 interacting genes: CDC42 FNTA GNG2 KRAS RHOB RRAS2	18 interacting genes: ARHGDIG ARHGEF3 CIT FNTA MAP1A NEDD4L PDE6D PGGT1B PIAS1 PKN1 PPP2CA RHPN2 ROCK1 RTKN SMURF1 TNFAIP1 UBE2I ZKSCAN5
Entrez ID		5229	388
HPRD ID		03612	01321
Ensembl ID		ENSG00000164219	ENSG00000143878
Uniprot IDs		P53609	P62745
PDB IDs		Not available	2FV8 6HXU 6SGE
GO Terms Enriched among Interactors		GDP Binding GTPase Activity Small GTPase-mediated Signal Transduction GTP Binding Focal Adhesion Positive Regulation Of Rac Protein Signal Transduction Regulation Of Rac Protein Signal Transduction Intracellular Signaling Cassette Signal Transduction G Protein Activity Positive Regulation Of Small GTPase Mediated Signal Transduction Plasma Membrane Peptide Pheromone Maturation Ras Protein Signal Transduction Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility GBD Domain Binding Storage Vacuole CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Protein Farnesyltransferase Activity Protein Farnesyltransferase Complex Positive Regulation Of Locomotion Endothelin Receptor Signaling Pathway Involved In Heart Process Golgi Membrane Protein Farnesylation GMP Binding Forebrain Astrocyte Development Positive Regulation Of Schwann Cell Migration Schwann Cell Migration Nucleotide Binding Apolipoprotein A-I Receptor Binding Neuropilin Signaling Pathway Rab Geranylgeranyltransferase Activity Protein Geranylgeranyltransferase Activity Response To Isolation Stress Intracellular Signal Transduction Protein Prenyltransferase Activity Protein Geranylgeranylation LRR Domain Binding Positive Regulation Of Pinocytosis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Response To Gravity Extracellular Exosome Regulation Of Cell Migration Actin Filament Organization Leading Edge Membrane Thioesterase Binding	Rho Protein Signal Transduction CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Protein Modification Process Protein Geranylgeranyltransferase Activity Cytosol Protein Prenyltransferase Activity Small GTPase Binding Protein Geranylgeranylation Tau Protein Binding Protein Prenylation Prenyltransferase Activity Transferase Activity Mitotic Cytokinesis GTPase Inhibitor Activity Cytoskeleton-dependent Cytokinesis Regulation Of Intracellular Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Microtubule-based Process SUMO Transferase Activity Receptor Catabolic Process Positive Regulation Of Dendrite Extension Regulation Of Cytoskeleton Organization Post-translational Protein Modification Actomyosin Structure Organization Renal System Process Negative Regulation Of Hippo Signaling Apoptotic Process Cytoplasm Regulation Of Protein Localization Cell Death Programmed Cell Death Presynaptic Cytosol Postsynaptic Cytosol Cortical Actin Cytoskeleton Organization Regulation Of Cell Communication Regulation Of Signaling Protein Metabolic Process Epithelial Cell Migration Regulation Of Signal Transduction Signal Transduction System Process Neuromuscular Junction Development Microtubule Associated Complex Regulation Of Microtubule Cytoskeleton Organization Regulation Of Protein Localization To Cell Surface Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Supramolecular Fiber Organization Protein Modification By Small Protein Conjugation