RAPGEF3 and MAP1A

Number of citations of the paper that reports this interaction (PubMedID 15202935)
28

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		RAPGEF3	MAP1A
Description		Rap guanine nucleotide exchange factor 3	microtubule associated protein 1A
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Microvillus Endomembrane System Membrane Lamellipodium Filopodium Cortical Actin Cytoskeleton Extracellular Exosome	Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Axon Dendrite Neuron Projection Neuronal Cell Body Axon Initial Segment Dendritic Shaft Dendritic Branch Synapse Primary Dendrite Dendritic Microtubule Axon Cytoplasm
	Molecular Function	Nucleotide Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Domain Specific Binding CAMP Binding	Actin Binding Structural Molecule Activity Protein Binding Microtubule Binding Cytoskeletal Anchor Activity Tubulin Binding Tau Protein Binding
	Biological Process	Angiogenesis Adaptive Immune Response Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Associative Learning Rap Protein Signal Transduction Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Intracellular Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Protein Export From Nucleus Regulation Of Insulin Secretion Positive Regulation Of Stress Fiber Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Establishment Of Endothelial Barrier Cellular Response To CAMP	Microtubule Cytoskeleton Organization Axonogenesis Memory Associative Learning Dendrite Development Regulation Of Microtubule Depolymerization Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Synaptic Plasticity Voluntary Musculoskeletal Movement Neuron Cellular Homeostasis Anterograde Axonal Protein Transport Retrograde Axonal Protein Transport Negative Regulation Of Protein Localization To Microtubule Positive Regulation Of Protein Localization Neuron Projection Maintenance Positive Regulation Of Protein Localization To Cell Surface
Pathways		Integrin signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion
Drugs			Estramustine
Diseases
GWAS		A body shape index ( 34021172) Bipolar disorder ( 31043756) Body mass index ( 29273807) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Platelet distribution width ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Hemoglobin levels ( 32327693) Platelet count ( 27863252) Plateletcrit ( 27863252) Triglyceride levels x fish oil supplementation interaction (2df) ( 33760818) Triglycerides ( 24507774 30275531)
Interacting Genes		14 interacting genes: AP1M1 AP2B1 DAPK1 DDX6 EXOC8 MAP1A OARD1 PNMA1 RAP1A RAP2A RRAS2 TGFB1 UFSP1 ZRANB1	28 interacting genes: ACTA1 ACTG1 AP1G1 ARHGEF11 CACNB4 CSNK2A1 DISC1 DLG1 DLG2 DLG4 GRB2 HTR2A KCNMA1 MAP1B MAP1LC3A NXF1 NXF2 OGT PRKAR1A RAPGEF3 RAPGEF4 RHOB SFN SPP1 TUBA4A TUBB UPF2 WEE2-AS1
Entrez ID		10411	4130
HPRD ID		06928	02549
Ensembl ID		ENSG00000079337	ENSG00000166963
Uniprot IDs		O95398 Q99777	E9PGC8 P78559 Q504X9
PDB IDs		6H7E
Enriched GO Terms of Interacting Partners?		Clathrin Adaptor Complex GDP Binding Rap Protein Signal Transduction Clathrin Adaptor Activity Response To Hydroperoxide GTP Binding Hydrolase Activity Intracellular Protein Localization Establishment Of Protein Localization Regulation Of Protein Localization To Membrane Regulation Of Response To Tumor Cell DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Concave Side Of Sperm Head Liver Regeneration Regulation Of Collagen Metabolic Process Response To Ketone Regulation Of Collagen Biosynthetic Process Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Cellular Response To Wortmannin Branch Elongation Involved In Mammary Gland Duct Branching Positive Regulation Of Microglia Differentiation Cellular Response To Acetaldehyde ADP-ribosyl-[dinitrogen Reductase] Hydrolase Activity Cellular Localization Protein Transport Intracellular Protein Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Viral RNA Genome Packaging Retrograde Axonal Protein Transport Primary Dendrite Response To Antineoplastic Agent Small GTPase-mediated Signal Transduction Animal Organ Regeneration G Protein Activity Positive Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Blood Vessel Endothelial Cell Migration Response To Wortmannin Positive Regulation Of Primary MiRNA Processing Embryonic Liver Development Purine Nucleoside Binding DeUFMylase Activity	Synapse Cytosol Glutamatergic Synapse Protein Kinase Binding Intracellular Protein Localization Organelle Organization Cellular Localization Regulation Of Transport Establishment Or Maintenance Of Cell Polarity CAMP Binding Neuromuscular Junction Regulation Of Cellular Component Organization Protein Localization To Cell Junction Intracellular Transport Intracellular Signal Transduction Establishment Of Localization In Cell Regulation Of Biological Quality Ionotropic Glutamate Receptor Binding Microtubule Muscle Contraction Cytoskeleton Organization Structural Constituent Of Cytoskeleton Regulation Of Secretion By Cell Presynapse Axon Regulation Of Cell Growth Non-canonical Inflammasome Complex Assembly Muscle System Process Regulation Of Secretion Intracellular Signaling Cassette Postsynaptic Density Nuclear Export Odontoblast Differentiation Nuclear RNA Export Factor Complex Small GTPase-mediated Signal Transduction Positive Regulation Of Protein Localization Receptor Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Urinary Bladder Smooth Muscle Contraction Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity GMP Kinase Activity Smooth Muscle Contraction Regulation Of Synapse Organization Protein Localization To Synapse Positive Regulation Of Cell Growth Chemical Synaptic Transmission GDP Metabolic Process Positive Regulation Of Supramolecular Fiber Organization Juxtaparanode Region Of Axon
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