CASC3 and PTPRJ

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		CASC3	PTPRJ
Description		CASC3 exon junction complex subunit	protein tyrosine phosphatase receptor type J
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Speck Dendrite Nuclear Membrane Exon-exon Junction Complex Cytoplasmic Ribonucleoprotein Granule Cell Projection Perinuclear Region Of Cytoplasm U2-type Catalytic Step 1 Spliceosome Ribonucleoprotein Complex	Immunological Synapse Extracellular Region Nucleoplasm Nucleolus Plasma Membrane Cell-cell Junction Cell Surface Membrane Nuclear Body Cell Junction Ruffle Membrane Specific Granule Membrane Cell Projection Extracellular Exosome Anchoring Junction
	Molecular Function	RNA Binding MRNA Binding Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Beta-catenin Binding Hydrolase Activity Phosphatase Activity Protein Kinase Binding Gamma-catenin Binding Cadherin Binding Mitogen-activated Protein Kinase Binding Delta-catenin Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome MRNA Processing MRNA Export From Nucleus Regulation Of Translation Intracellular MRNA Localization RNA Splicing MRNA Transport Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Angiogenesis Vasculogenesis Positive Regulation Of Cell-matrix Adhesion Immune System Process Signal Transduction Axon Guidance Heart Development Blood Coagulation Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Positive Regulation Of Platelet Activation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Macrophage Chemotaxis Cytokine-mediated Signaling Pathway Hemopoiesis Regulation Of Cell Adhesion B Cell Differentiation Platelet Formation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Positive Regulation Of Tumor Necrosis Factor Production Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Glucose Homeostasis Negative Regulation Of Vascular Permeability Negative Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Adhesion Negative Regulation Of Insulin Receptor Signaling Pathway Platelet-derived Growth Factor Receptor Signaling Pathway Oligodendrocyte Differentiation Positive Regulation Of Phagocytosis Positive Regulation Of Immune Response Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Positive Chemotaxis Positive Regulation Of Cellular Component Organization Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Contact Inhibition Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Biological Quality Positive Regulation Of Intracellular Signal Transduction
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Phosphorylation of CD3 and TCR zeta chains Neutrophil degranulation Negative regulation of MET activity Negative regulation of FLT3
Drugs
Diseases
GWAS		Asthma ( 31619474) Household income ( 31844048)	Acute lymphoblastic leukemia (childhood) ( 22076464) Alanine aminotransferase levels ( 33547301) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Caffeine consumption from coffee or tea ( 33287642) D-dimer levels ( 21502573) Experiencing mood swings ( 29500382) Heel bone mineral density ( 30598549) Height ( 28552196 25282103 23563607) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hypertension ( 31879980) Intraocular pressure ( 31798171 31959993 30054594 29785010 29617998 29235454 25173106) Kawasaki disease ( 33692975) Lymphocyte count ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Offspring birth weight ( 31043758) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Serum metabolite concentrations in chronic kidney disease ( 33838163) Sleep duration (short sleep) ( 30846698)
Interacting Genes		17 interacting genes: AKT1 APC CASP8 CDK6 CDKN2A EIF4A3 ESR2 FGFR4 GRB2 KRTAP6-2 MIR128-1 NBN PHB1 PTPN1 PTPRJ STAU1 TSC1	37 interacting genes: ANP32B BAAT BAP1 CASC3 CNKSR1 CTNNB1 CTNND1 CYP17A1 EGFR EPSTI1 FANCC FBP1 HEMGN HOXC6 HRAS IL2RG JUP KLK7 KLK9 LAT LYPD3 MAP2K1 MET NANS NOP2 PDGFRB PLCG1 PPP2CB PPP3R2 PRDM14 RASA1 SDCBP SFRP4 TMEFF1 TRMO TSTD2 ZNF510
Entrez ID		22794	5795
HPRD ID		16225	02955
Ensembl ID		ENSG00000108349	ENSG00000149177
Uniprot IDs		O15234	Q12913 Q9NPR5
PDB IDs		2HYI 2J0Q 2J0S 2J0U 2XB2 3EX7 5XJC 5YZG 6ICZ 7W59 7W5A 7W5B 8I0W	2CFV 2DLE 2NZ6 7U01 7U08
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Metabolic Process Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Lymphocyte Activation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Adhesion Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Protein Kinase Activity Leukocyte Activation Insulin Receptor Signaling Pathway Negative Regulation Of Kinase Activity Regulation Of Proteolysis Cell Activation Regulation Of Cell-substrate Adhesion Regulation Of Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Protein Phosphorylation Protein Kinase Binding Negative Regulation Of Cell Population Proliferation Negative Regulation Of Phosphorylation Regulation Of Cellular Component Organization Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Adhesion Regulation Of Cell-matrix Adhesion Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stress Regulation Of Immune System Process Regulation Of Biological Quality Negative Regulation Of Immune System Process Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Positive Regulation Of Gene Expression Regulation Of Cell Population Proliferation Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Catalytic Activity Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Phosphate Metabolic Process Negative Regulation Of Cell Growth Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Negative Regulation Of Catabolic Process Positive Regulation Of Cell-matrix Adhesion Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Multicellular Organismal Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Catenin-TCF7L2 Complex Phospholipase C Activator Activity ERBB Signaling Pathway Cellular Response To Indole-3-methanol Positive Regulation Of MAPK Cascade Catenin Complex Cell Morphogenesis Protein Phosphatase Binding Regulation Of Intracellular Signal Transduction Positive Regulation Of Locomotion Positive Regulation Of Cell Motility Regulation Of Signal Transduction Response To Indole-3-methanol Cell-cell Junction Trachea Formation Regulation Of Blood Vessel Branching Regulation Of Calcium Ion Import Regulation Of Ras Protein Signal Transduction Positive Regulation Of Cell Migration Protein Tyrosine Kinase Activity Alpha-catenin Binding Phosphatase Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Phosphorylation Vasculature Development Regulation Of Cell Motility Focal Adhesion Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Transport Regulation Of Signaling Regulation Of Locomotion Negative Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Transport Intracellular Signaling Cassette Tube Morphogenesis Regulation Of MAPK Cascade Histone Methyltransferase Binding Regulation Of Cell Population Proliferation Ciliary Basal Body Negative Regulation Of Programmed Cell Death Positive Regulation Of Phosphate Metabolic Process Regulation Of Protein Localization Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Ras Protein Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Adherens Junction
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