CASC3 and NBN

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		CASC3	NBN
Description		CASC3 exon junction complex subunit	nibrin
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Speck Dendrite Nuclear Membrane Exon-exon Junction Complex Cytoplasmic Ribonucleoprotein Granule Cell Projection Perinuclear Region Of Cytoplasm U2-type Catalytic Step 1 Spliceosome Ribonucleoprotein Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Chromosome Nucleolus Golgi Apparatus Cytosol PML Body Mre11 Complex Site Of Double-strand Break Nuclear Inclusion Body BRCA1-C Complex Chromosomal Region
	Molecular Function	RNA Binding MRNA Binding Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding	Damaged DNA Binding Protein Binding Histone Binding Protein Serine/threonine Kinase Activator Activity Phosphorylation-dependent Protein Binding DNA-binding Transcription Factor Binding Chromatin-protein Adaptor Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome MRNA Processing MRNA Export From Nucleus Regulation Of Translation Intracellular MRNA Localization RNA Splicing MRNA Transport Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	DNA Damage Checkpoint Signaling Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing In Utero Embryonic Development Blastocyst Growth DNA Repair Double-strand Break Repair DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Neuroblast Proliferation Regulation Of DNA-templated DNA Replication Initiation DNA Damage Response, Signal Transduction By P53 Class Mediator Protection From Non-homologous End Joining At Telomere Telomeric 3' Overhang Formation Positive Regulation Of Telomere Maintenance Homologous Recombination Telomere Maintenance In Response To DNA Damage Mitotic G2/M Transition Checkpoint Isotype Switching Neuromuscular Process Controlling Balance Meiotic Cell Cycle Regulation Of Cell Cycle R-loop Processing Protein K63-linked Ubiquitination T-circle Formation Telomere Maintenance Via Telomere Trimming Intrinsic Apoptotic Signaling Pathway Double-strand Break Repair Via Alternative Nonhomologous End Joining DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of Telomere Capping Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break Positive Regulation Of Double-strand Break Repair
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	DNA Damage/Telomere Stress Induced Senescence HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs
Diseases			DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS		Asthma ( 31619474) Household income ( 31844048)	Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494)
Interacting Genes		17 interacting genes: AKT1 APC CASP8 CDK6 CDKN2A EIF4A3 ESR2 FGFR4 GRB2 KRTAP6-2 MIR128-1 NBN PHB1 PTPN1 PTPRJ STAU1 TSC1	35 interacting genes: ATF2 ATM ATR BAP1 BRCA1 CASC3 CCNE1 CDK9 CHEK2 DCLRE1C EP300 FANCD2 H2AX H3-4 HIF1A MDC1 MRE11 NABP2 NAT2 NCL PRKDC RAD50 RAD51 RECQL5 SIRT1 SNAI1 SUMO2 TERF1 TLK1 TREX1 UBE2D1 UBE2N VRK1 XRCC4 XRCC5
Entrez ID		22794	4683
HPRD ID		16225	04050
Ensembl ID		ENSG00000108349	ENSG00000104320
Uniprot IDs		O15234	A0A0C4DG07 O60934
PDB IDs		2HYI 2J0Q 2J0S 2J0U 2XB2 3EX7 5XJC 5YZG 6ICZ 7W59 7W5A 7W5B 8I0W	5WQD 7SID 8BAH
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Metabolic Process Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Lymphocyte Activation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Adhesion Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Protein Kinase Activity Leukocyte Activation Insulin Receptor Signaling Pathway Negative Regulation Of Kinase Activity Regulation Of Proteolysis Cell Activation Regulation Of Cell-substrate Adhesion Regulation Of Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Protein Phosphorylation Protein Kinase Binding Negative Regulation Of Cell Population Proliferation Negative Regulation Of Phosphorylation Regulation Of Cellular Component Organization Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Adhesion Regulation Of Cell-matrix Adhesion Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stress Regulation Of Immune System Process Regulation Of Biological Quality Negative Regulation Of Immune System Process Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Positive Regulation Of Gene Expression Regulation Of Cell Population Proliferation Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Catalytic Activity Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Phosphate Metabolic Process Negative Regulation Of Cell Growth Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Negative Regulation Of Catabolic Process Positive Regulation Of Cell-matrix Adhesion Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Multicellular Organismal Process	DNA Damage Response DNA Metabolic Process DNA Repair Double-strand Break Repair Response To Ionizing Radiation Nucleoplasm Cellular Response To Stress Negative Regulation Of Cell Cycle Process DNA Recombination Chromosome, Telomeric Region DNA Damage Checkpoint Signaling Response To Radiation Negative Regulation Of Cell Cycle Nucleic Acid Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of DNA Metabolic Process Regulation Of DNA Repair Regulation Of Cellular Response To Stress Regulation Of Cell Cycle Phase Transition Recombinational Repair Regulation Of Double-strand Break Repair Telomere Maintenance Negative Regulation Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Regulation Of Cell Cycle Process Mitotic DNA Damage Checkpoint Signaling Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Regulation Of Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Telomere Organization Chromosome Nucleobase-containing Compound Metabolic Process Chromatin Organization Double-strand Break Repair Via Homologous Recombination Response To Gamma Radiation Macromolecule Metabolic Process Positive Regulation Of DNA Metabolic Process Site Of Double-strand Break Cellular Response To Ionizing Radiation Positive Regulation Of DNA Repair Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromosome Organization Involved In Meiotic Cell Cycle Chromatin Remodeling Cellular Response To Gamma Radiation Positive Regulation Of Double-strand Break Repair DNA Binding Regulation Of Primary Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?