CASC3 and EIF4A3

Number of citations of the paper that reports this interaction (PubMedID 14973490)
0

Data Source:
HPRD (two hybrid, in vitro)

		CASC3	EIF4A3
Description		CASC3 exon junction complex subunit	eukaryotic translation initiation factor 4A3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Speck Dendrite Nuclear Membrane Exon-exon Junction Complex Cytoplasmic Ribonucleoprotein Granule Cell Projection Perinuclear Region Of Cytoplasm U2-type Catalytic Step 1 Spliceosome Ribonucleoprotein Complex	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Cytosol Membrane Nuclear Speck Dendrite Exon-exon Junction Complex Neuronal Cell Body U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome Postsynapse Glutamatergic Synapse Ribonucleoprotein Complex
	Molecular Function	RNA Binding MRNA Binding Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding Poly(A) Binding Hydrolase Activity ATP Hydrolysis Activity Selenocysteine Insertion Sequence Binding RNA Stem-loop Binding Ribonucleoprotein Complex Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome MRNA Processing MRNA Export From Nucleus Regulation Of Translation Intracellular MRNA Localization RNA Splicing MRNA Transport Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome RRNA Processing MRNA Processing MRNA Export From Nucleus Regulation Of Translation Associative Learning RNA Splicing Negative Regulation Of Gene Expression Negative Regulation Of Translation Exploration Behavior Positive Regulation Of Translation Embryonic Cranial Skeleton Morphogenesis MRNA Transport Cellular Response To Selenite Ion Negative Regulation Of Excitatory Postsynaptic Potential Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Selenocysteine Incorporation Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	ISG15 antiviral mechanism Transport of Mature mRNA derived from an Intron-Containing Transcript Deadenylation of mRNA Deadenylation of mRNA mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors
Drugs
Diseases
GWAS		Asthma ( 31619474) Household income ( 31844048)	High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myocardial infarction ( 26708285) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		17 interacting genes: AKT1 APC CASP8 CDK6 CDKN2A EIF4A3 ESR2 FGFR4 GRB2 KRTAP6-2 MIR128-1 NBN PHB1 PTPN1 PTPRJ STAU1 TSC1	38 interacting genes: ANKHD1 CARD9 CASC3 CCDC174 CDCA7L CEBPA CNKSR3 CTNND1 CWC22 DDIT4L DDX56 DISC1 DRG2 EHMT2 ERCC6 ESR1 HTR6 LNX1 MAGOH MEOX1 MEOX2 NIF3L1 NXF1 PAX4 PDCD4 PICK1 POLR2G PRMT5 PSMA1 RBM8A REL TRIM27 UPF1 UPF3B USP25 VRTN YWHAQ ZXDB
Entrez ID		22794	9775
HPRD ID		16225	06482
Ensembl ID		ENSG00000108349	ENSG00000141543
Uniprot IDs		O15234	I3L3H2 P38919
PDB IDs		2HYI 2J0Q 2J0S 2J0U 2XB2 3EX7 5XJC 5YZG 6ICZ 7W59 7W5A 7W5B 8I0W	2HXY 2HYI 2J0Q 2J0S 2J0U 2XB2 3EX7 4C9B 5MQF 5XJC 5YZG 6ICZ 6QDV 6YVH 7A5P 7W59 7W5A 7W5B 7ZNJ 8C6J 8I0W 9FMD
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Metabolic Process Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Lymphocyte Activation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Adhesion Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Protein Kinase Activity Leukocyte Activation Insulin Receptor Signaling Pathway Negative Regulation Of Kinase Activity Regulation Of Proteolysis Cell Activation Regulation Of Cell-substrate Adhesion Regulation Of Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Protein Phosphorylation Protein Kinase Binding Negative Regulation Of Cell Population Proliferation Negative Regulation Of Phosphorylation Regulation Of Cellular Component Organization Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Adhesion Regulation Of Cell-matrix Adhesion Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stress Regulation Of Immune System Process Regulation Of Biological Quality Negative Regulation Of Immune System Process Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Positive Regulation Of Gene Expression Regulation Of Cell Population Proliferation Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Catalytic Activity Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Phosphate Metabolic Process Negative Regulation Of Cell Growth Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Negative Regulation Of Catabolic Process Positive Regulation Of Cell-matrix Adhesion Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Multicellular Organismal Process	Exon-exon Junction Complex Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of Macromolecule Metabolic Process Nuclear-transcribed MRNA Catabolic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Metabolic Process Regulation Of Gene Expression MRNA Export From Nucleus MRNA Transport MRNA Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process Negative Regulation Of Gene Expression RNA Export From Nucleus RNA Transport Negative Regulation Of Macromolecule Biosynthetic Process U2-type Catalytic Step 1 Spliceosome Negative Regulation Of Biosynthetic Process Regulation Of RNA Splicing Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RNA Catabolic Process Nucleobase-containing Compound Transport Nuclear Export Exon-exon Junction Subcomplex Mago-y14 Regulation Of Protein Metabolic Process Nuclear Transport Nucleocytoplasmic Transport Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Positive Regulation Of MRNA Splicing, Via Spliceosome RNA Metabolic Process Nuclear Speck Somite Specification Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding RNA Binding Chromatin Nucleoplasm Positive Regulation Of RNA Metabolic Process Nucleobase-containing Compound Catabolic Process Positive Regulation Of RNA Splicing Negative Regulation Of Type I Interferon Production Nucleic Acid Binding
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