CASC3 and EIF4A3

Number of citations of the paper that reports this interaction (PMID 14973490)
88

Data Source:
HPRD (in vitro, two hybrid)

		CASC3	EIF4A3
Gene Name		cancer susceptibility candidate 3	eukaryotic translation initiation factor 4A3
Image
Gene Ontology Annotations	Cellular Component	Cytosol Nuclear Speck Ribonucleoprotein Complex Exon-exon Junction Complex Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Speck Exon-exon Junction Complex Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Poly(A) RNA Binding	MRNA Binding ATP-dependent RNA Helicase Activity Protein Binding ATP Binding Poly(A) Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Processing Regulation Of Translation Biological_process Intracellular MRNA Localization RNA Splicing Gene Expression MRNA Transport	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Splicing, Via Spliceosome RRNA Processing Gene Expression Negative Regulation Of Translation Cytokine-mediated Signaling Pathway Positive Regulation Of Translation Embryonic Cranial Skeleton Morphogenesis MRNA Transport
Pathways		Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Deadenylation of mRNA ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CDK6 EIF4A3 GRB2 STAU1	9 interactors: CASC3 CCDC174 CDCA7L MAGOH NXF1 PDCD4 RBM8A UPF1 YWHAQ
Entrez ID		22794	9775
HPRD ID		16225	06482
Ensembl ID		ENSG00000108349	ENSG00000141543
Uniprot IDs		B4DKR6 O15234	P38919
PDB IDs		2HYI 2J0Q 2J0S 2J0U 2XB2 3EX7	2HXY 2HYI 2J0Q 2J0S 2J0U 2XB2 3EX7
Enriched GO Terms of Interacting Partners?		Cell Dedifferentiation RNA Localization Positive Regulation By Virus Of Viral Protein Levels In Host Cell	MRNA Transport RNA Transport RNA Localization MRNA Export From Nucleus RNA Export From Nucleus Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear Export Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Nucleocytoplasmic Transport Nuclear Transport Regulation Of Translation Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression MRNA Metabolic Process Cellular Localization Regulation Of Alternative MRNA Splicing, Via Spliceosome Cytoplasmic Transport Intracellular Transport Termination Of RNA Polymerase II Transcription Cellular Macromolecule Catabolic Process Regulation Of Gene Expression RNA Splicing Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Gene Expression Regulation Of MRNA Splicing, Via Spliceosome DNA-templated Transcription, Termination MRNA Processing Regulation Of Protein Metabolic Process MRNA 3'-end Processing Regulation Of MRNA Processing Regulation Of RNA Splicing RNA 3'-end Processing RNA Processing Transport RNA Metabolic Process Catabolic Process Regulation Of Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Histone MRNA Catabolic Process Poly(A)+ MRNA Export From Nucleus Intracellular MRNA Localization Dosage Compensation By Inactivation Of X Chromosome Regulation Of Translational Termination Negative Regulation Of JUN Kinase Activity Dosage Compensation Histone MRNA Metabolic Process
Tagcloud ?		appearance bodies core correlate correlates cytoplasm cytoplasmic deregulation determining disassembly eif4aiii ejc exon fate foci granules junction loaded localizes magoh mln51 movements onto overexpressed overexpressing rbm8a spliced unlike y14	attained chmp4c conceptually dba deg degs domestication dudeg dudegs ehh foxo3 fst homozygosity horse ideas integrating jeju kegg ontology pony rba reads seq thoroughbred thoroughbreds timeless wgs xp znf592
Tagcloud (Difference) ?		appearance bodies core correlate correlates cytoplasm cytoplasmic deregulation determining disassembly eif4aiii ejc exon fate foci granules junction loaded localizes magoh mln51 movements onto overexpressed overexpressing rbm8a spliced unlike y14	attained chmp4c conceptually dba deg degs domestication dudeg dudegs ehh foxo3 fst homozygosity horse ideas integrating jeju kegg ontology pony rba reads seq thoroughbred thoroughbreds timeless wgs xp znf592
Tagcloud (Intersection) ?