FHL1 and AKAP12

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		FHL1	AKAP12
Gene Name		four and a half LIM domains 1	A kinase (PRKA) anchor protein 12
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion	Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex
	Molecular Function	Molecular_function Protein Binding Zinc Ion Binding Ion Channel Binding	Protein Binding Adenylate Cyclase Binding Protein Kinase A Binding
	Biological Process	Regulation Of Membrane Depolarization Muscle Organ Development Organ Morphogenesis Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of Potassium Ion Transport Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Protein Targeting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Protein Kinase A Signaling Positive Regulation Of CAMP Biosynthetic Process Regulation Of Protein Kinase C Signaling
Pathways
Drugs
Diseases
GWAS			Chronic myeloid leukemia ( 21540461)
Protein-Protein Interactions		19 interactors: AKAP12 CBX4 DBN1 DEAF1 EED FHL2 HES1 HIVEP3 MYBPC1 PDE4DIP PRNP RBPJ RING1 SRF SRPK1 TTN TXNIP UBE2E2 USP15	6 interactors: ADRB2 ADRBK1 EGFR FHL1 PRKAR2A PRKCA
Entrez ID		2273	9590
HPRD ID		02157	05263
Ensembl ID		ENSG00000022267	ENSG00000131016
Uniprot IDs		B7Z9A1 Q13642	Q02952 Q86TJ9
PDB IDs		1X63 2CUP 2CUR 2EGQ
Enriched GO Terms of Interacting Partners?		Cardiocyte Differentiation Heart Morphogenesis Aorta Morphogenesis Negative Regulation Of Transcription, DNA-templated Heart Trabecula Morphogenesis Aorta Development Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Muscle Structure Development Transcription, DNA-templated Regulation Of RNA Metabolic Process Striated Muscle Tissue Development Negative Regulation Of Gene Expression RNA Biosynthetic Process Muscle Cell Differentiation Cardiac Chamber Development Negative Regulation Of Biosynthetic Process Muscle Tissue Development Trabecula Morphogenesis RNA Metabolic Process Auditory Receptor Cell Fate Commitment Dorsal Aorta Morphogenesis Regulation Of Gene Expression Muscle Cell Development Artery Morphogenesis Dorsal Aorta Development Cell Differentiation Negative Regulation Of Cellular Metabolic Process Cardiac Muscle Tissue Development Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Regulation Of Transcription, DNA-templated Artery Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cardiac Muscle Cell Development Tissue Development Regulation Of Metabolic Process Cardiac Muscle Cell Myoblast Differentiation Nucleobase-containing Compound Metabolic Process Cell Development Heart Development Regulation Of Transcription From RNA Polymerase II Promoter Cardioblast Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Anatomical Structure Development Heart Trabecula Formation Cellular Nitrogen Compound Metabolic Process	Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Muscle Contraction Response To Growth Factor Positive Regulation Of Catalytic Activity Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Muscle Contraction Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Innate Immune Response Activation Of Adenylate Cyclase Activity Positive Regulation Of Phosphorylation Regulation Of The Force Of Heart Contraction Activation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Adenylate Cyclase Activity Regulation Of Vasodilation Regulation Of Cellular Localization Positive Regulation Of Hydrolase Activity Regulation Of Protein Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Lyase Activity Regulation Of Catalytic Activity Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Adenylate Cyclase Activity Negative Regulation Of Signaling Regulation Of Mitotic Cell Cycle Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process Immune Response Positive Regulation Of MAPK Cascade Regulation Of Phosphorylation
Tagcloud ?		764g atrophy biopsy bodies boy cardiomyopathy distal dreifuss dystrophy echocardiogram emery exon hemizygous hypertrophic linked missense muscle muscular myopathy occurring pathology postural predominantly reducing scapuloperoneal sequencing vacuolar wasting weakness	actin blotting compromised cytoskeletal diverse finding gossypol gynecological hippo hoc1a lats1 mediating organization ovarian phosphopeptides phosphoproteins phosphoproteomic phosphorylates platinum qpcr recurs ser showing traditional untreated upregulation urgently valuable yap1
Tagcloud (Difference) ?		764g atrophy biopsy bodies boy cardiomyopathy distal dreifuss dystrophy echocardiogram emery exon hemizygous hypertrophic linked missense muscle muscular myopathy occurring pathology postural predominantly reducing scapuloperoneal sequencing vacuolar wasting weakness	actin blotting compromised cytoskeletal diverse finding gossypol gynecological hippo hoc1a lats1 mediating organization ovarian phosphopeptides phosphoproteins phosphoproteomic phosphorylates platinum qpcr recurs ser showing traditional untreated upregulation urgently valuable yap1
Tagcloud (Intersection) ?