GPC4 and COL18A1

Number of citations: 0 (PubMedID 11336704)
Data Source: HPRD (in vitro)

		GPC4	COL18A1
Name		glypican 4	collagen type XVIII alpha 1 chain
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Golgi Lumen Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Lysosomal Lumen Synapse Extracellular Exosome Side Of Membrane Glutamatergic Synapse	Extracellular Region Collagen Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Binding Coreceptor Activity	Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Identical Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Signal Transduction Wnt Signaling Pathway Cell Migration Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Synaptic Membrane Adhesion Regulation Of Presynapse Assembly	Skeletal System Development Angiogenesis Endothelial Cell Morphogenesis Cell Adhesion Visual Perception Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Anatomical Structure Morphogenesis Animal Organ Morphogenesis Regulation Of Cell Population Proliferation Response To Hydrostatic Pressure
Pathways		Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions	Collagen degradation Activation of Matrix Metalloproteinases Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Laminin interactions Collagen chain trimerization
Diseases		None	Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC) Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
GWAS		No GWAS studies recorded	Ankle injury ( 28957384 ) Apolipoprotein A1 levels ( 32203549 ) Blood protein levels ( 30072576 ) Bone mineral density (total hip) ( 29883787 ) Brain morphology (MOSTest) ( 32665545 ) Cardiorespiratory fitness (800m run time) ( 32572135 ) Early-onset Parkinson's disease ( 28256260 ) HDL cholesterol levels ( 32203549 ) Hippocampal atrophy ( 22745009 ) Left–right brain asymmetry ( 33723403 ) Platelet distribution width ( 32888494 ) Pursuit maintenance gain ( 29064472 ) Total cholesterol levels ( 30275531 ) Triglycerides ( 24507774 30275531 )
Interacting Genes		10 interacting genes: ABHD17A ACP5 AKAP9 CCNC COL18A1 FGF2 PICK1 PTEN PTPRD PTPRF	19 interacting genes: APP BGN COL1A1 COL4A1 COL6A1 CTSL FBLN2 GPC1 GPC4 HNRNPD ITGA5 ITGAV ITGB1 KDR LAMA1 MMP2 SPARC TGM2 THBS1
Entrez ID		2239	80781
HPRD ID		02160	00382
Ensembl ID		ENSG00000076716	ENSG00000182871
Uniprot IDs		O75487	A0AAG2UW65 A0AAG2UXZ5 P39060
PDB IDs		Not available	1BNL 3HON 3HSH
GO Terms Enriched among Interactors		Presynaptic Membrane Organization Presynaptic Membrane Assembly Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Phosphoprotein Phosphatase Activity Synaptic Membrane Adhesion Regulation Of Response To Wounding Dendritic Spine Organization Identical Protein Binding System Development Nervous System Development Neuron Projection Organization Response To Electrical Stimulus Postsynapse Organization Negative Regulation Of Superoxide Anion Generation Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Cell-cell Signaling Cell Communication Signaling Membrane Organization Postsynaptic Density Negative Regulation Of Synaptic Vesicle Clustering Membrane Assembly Chondroitin Sulfate Proteoglycan Binding Response To Stress Response To Wortmannin Positive Regulation Of Inner Ear Receptor Cell Differentiation Negative Regulation Of Wound Healing Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Cell Fate Specification Positive Regulation Of Lens Fiber Cell Differentiation Positive Regulation Of Inner Ear Auditory Receptor Cell Differentiation Neuron Projection Trans-synaptic Signaling Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Synaptic Signaling Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Regulation Of Neurogenesis Protein Dephosphorylation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Angiogenesis Involved In Coronary Vascular Morphogenesis Regulation Of Organ Growth Regulation Of Retinal Cell Programmed Cell Death Lymphatic Endothelial Cell Migration	Extracellular Matrix Extracellular Region Extracellular Matrix Structural Constituent Extracellular Matrix Binding Fibronectin Binding Cell Surface Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Adhesion Anatomical Structure Formation Involved In Morphogenesis Anatomical Structure Morphogenesis Positive Regulation Of Locomotion Integrin Binding Developmental Process Cellular Response To Amino Acid Stimulus Angiogenesis Endodermal Cell Differentiation External Side Of Plasma Membrane Regulation Of Cell-substrate Adhesion Response To Amino Acid Cellular Developmental Process Platelet-derived Growth Factor Binding Cell Migration Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Signal Transduction Coreceptor Activity Wound Healing, Spreading Of Epidermal Cells Collagen Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Motility Animal Organ Development Platelet Alpha Granule Integrin Alpha5-beta1 Complex Integrin Alphav-beta1 Complex Regulation Of Angiogenesis Laminin Binding Regulation Of Vasculature Development Positive Regulation Of Angiogenesis Positive Regulation Of Vasculature Development Response To Activity Fibroblast Growth Factor Binding Regulation Of Developmental Process Response To Mechanical Stimulus Cell Adhesion Cell Surface Receptor Signaling Pathway