GPC4 and MX1

Data Source: HiPPIP (Novel)

		GPC4	MX1
Name		glypican 4	MX dynamin like GTPase 1
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Golgi Lumen Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Lysosomal Lumen Synapse Extracellular Exosome Side Of Membrane Glutamatergic Synapse	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Microtubule Plasma Membrane Membrane Nuclear Membrane Synapse Perinuclear Region Of Cytoplasm Presynapse
	Molecular Function	Protein Binding Coreceptor Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Microtubule Binding Identical Protein Binding
	Biological Process	Regulation Of Signal Transduction Wnt Signaling Pathway Cell Migration Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Synaptic Membrane Adhesion Regulation Of Presynapse Assembly	Immune System Process Apoptotic Process Defense Response Signal Transduction Response To Virus Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Response To Type I Interferon Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Interleukin-27-mediated Signaling Pathway Antiviral Innate Immune Response
Pathways		Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions	ISG15 antiviral mechanism Interferon alpha/beta signaling
GWAS		No GWAS studies recorded	No GWAS studies recorded
Novel Interactors		1 novel interactors: MX1	13 novel interactors: CCL16 CD5 DCP2 GGPS1 GPC4 MX2 NDC80 NDUFV3 PDE9A PGRMC1 PRDX6 PSG9 ZFP36
Interacting Genes		10 interacting genes: ABHD17A ACP5 AKAP9 CCNC COL18A1 FGF2 PICK1 PTEN PTPRD PTPRF	42 interacting genes: ACTB ADRM1 APP BLM BRD7 C7orf25 CAB39L CASP8AP2 CBX4 CHD3 DAXX EPM2AIP1 FANCA FXR1 GMEB1 HMGXB4 KIF26B KLHL35 LRRC4B MCCD1 PIAS1 PIAS2 PLRG1 PSD3 RELA SIAH1 SIRPA SLC25A3 SP100 TDG TRPC1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TUBA1A TUBB ZBTB16 ZCCHC12 ZNF251 ZNF623
Entrez ID		2239	4599
HPRD ID		02160	00919
Ensembl ID		ENSG00000076716	ENSG00000157601
Uniprot IDs		O75487	H9KVC7 P20591
PDB IDs		Not available	3LJB 3SZR 3ZYS 4P4S 4P4T 4P4U 5GTM
GO Terms Enriched among Interactors		Presynaptic Membrane Organization Presynaptic Membrane Assembly Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Phosphoprotein Phosphatase Activity Synaptic Membrane Adhesion Regulation Of Response To Wounding Dendritic Spine Organization Identical Protein Binding System Development Nervous System Development Neuron Projection Organization Response To Electrical Stimulus Postsynapse Organization Negative Regulation Of Superoxide Anion Generation Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Cell-cell Signaling Cell Communication Signaling Membrane Organization Postsynaptic Density Negative Regulation Of Synaptic Vesicle Clustering Membrane Assembly Chondroitin Sulfate Proteoglycan Binding Response To Stress Response To Wortmannin Positive Regulation Of Inner Ear Receptor Cell Differentiation Negative Regulation Of Wound Healing Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Cell Fate Specification Positive Regulation Of Lens Fiber Cell Differentiation Positive Regulation Of Inner Ear Auditory Receptor Cell Differentiation Neuron Projection Trans-synaptic Signaling Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Synaptic Signaling Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Regulation Of Neurogenesis Protein Dephosphorylation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Angiogenesis Involved In Coronary Vascular Morphogenesis Regulation Of Organ Growth Regulation Of Retinal Cell Programmed Cell Death Lymphatic Endothelial Cell Migration	Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding Cation Channel Complex PML Body Regulation Of Cytosolic Calcium Ion Concentration Calcium Channel Activity Transcription Corepressor Activity Cytoplasmic Ribonucleoprotein Granule SUMO Ligase Activity Actinin Binding Negative Regulation Of Cytokine Production Involved In Inflammatory Response Monoatomic Ion Channel Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Calcium Ion Homeostasis SUMO Transferase Activity Calcium Ion Transmembrane Transport Calcium Ion Homeostasis Regulation Of Presynapse Organization Regulation Of Presynapse Assembly Positive Regulation Of Cell-cell Adhesion Negative Regulation Of RNA Metabolic Process Calcium Ion Transport Regulation Of Cytokine Production Involved In Inflammatory Response Nucleus Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell Development Regulation Of T Cell Activation Identical Protein Binding Regulation Of T Cell Differentiation Intracellular Monoatomic Cation Homeostasis Associative Learning Inorganic Ion Homeostasis Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Macromolecule Biosynthetic Process Protein Homodimerization Activity Intracellular Monoatomic Ion Homeostasis Negative Regulation Of Dendrite Morphogenesis Positive Regulation Of Cell Differentiation Regulation Of Synapse Organization Ubiquitin Protein Ligase Binding Regulation Of Multicellular Organismal Development Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Nuclear Envelope Lumen SUMO Binding Synapse Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of MiRNA-mediated Gene Silencing