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GPC4
Gene Name
glypican 4
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Proteinaceous Extracellular Matrix
Extracellular Space
Nucleus
Golgi Lumen
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Anchored Component Of Membrane
Lysosomal Lumen
Extracellular Vesicular Exosome
Molecular Function
Heparan Sulfate Proteoglycan Binding
Biological Process
Retinoid Metabolic Process
Carbohydrate Metabolic Process
Glycosaminoglycan Biosynthetic Process
Glycosaminoglycan Catabolic Process
Phototransduction, Visible Light
Cell Proliferation
Pathogenesis
Anatomical Structure Morphogenesis
Glycosaminoglycan Metabolic Process
Chondroitin Sulfate Metabolic Process
Small Molecule Metabolic Process
Pathways
MPS IIIB - Sanfilippo syndrome B
Diseases of glycosylation
Defective B4GALT7 causes EDS, progeroid type
Heparan sulfate/heparin (HS-GAG) metabolism
MPS I - Hurler syndrome
MPS IX - Natowicz syndrome
Chondroitin sulfate/dermatan sulfate metabolism
Defective SLC26A2 causes chondrodysplasias
Glycosaminoglycan metabolism
Defective CHST14 causes EDS, musculocontractural type
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective PAPSS2 causes SEMD-PA
MPS IIIA - Sanfilippo syndrome A
Myoclonic epilepsy of Lafora
Defective CHST6 causes MCDC1
Glycogen storage diseases
MPS IIID - Sanfilippo syndrome D
A tetrasaccharide linker sequence is required for GAG synthesis
MPS IIIC - Sanfilippo syndrome C
Retinoid metabolism and transport
Diseases associated with glycosaminoglycan metabolism
Mucopolysaccharidoses
Defective EXT2 causes exostoses 2
MPS II - Hunter syndrome
Defective B3GAT3 causes JDSSDHD
Defective CHST3 causes SEDCJD
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Diseases associated with visual transduction
MPS IV - Morquio syndrome A
Visual phototransduction
MPS IV - Morquio syndrome B
Defective CHSY1 causes TPBS
MPS VII - Sly syndrome
Metabolism of carbohydrates
HS-GAG biosynthesis
HS-GAG degradation
MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS
Protein-protein Interactions
3 interactors:
ACP5
COL18A1
FGF2
Entrez ID
2239
HPRD ID
02160
Ensembl ID
Uniprot IDs
B4E2C0
O75487
PDB IDs
Enriched GO Terms of Interacting Partners
?
Organ Morphogenesis
Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation
Negative Regulation Of Superoxide Anion Generation
Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Positive Regulation Of Cell Migration
Angiogenesis
Positive Regulation Of Cell Motility
Positive Regulation Of Cellular Component Movement
Positive Regulation Of Locomotion
Positive Regulation Of Cell Fate Specification
Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Chondroblast Differentiation
Riboflavin Metabolic Process
Extracellular Matrix Organization
Extracellular Structure Organization
Inositol Phosphate Biosynthetic Process
Regulation Of Satellite Cell Proliferation
Blood Vessel Morphogenesis
Positive Regulation Of Endothelial Cell Chemotaxis
Positive Regulation Of Sprouting Angiogenesis
Anatomical Structure Morphogenesis
Response To Hydrostatic Pressure
Positive Regulation Of Endothelial Cell Apoptotic Process
Blood Vessel Development
Regulation Of Superoxide Anion Generation
Vasculature Development
Negative Regulation Of Interleukin-1 Beta Production
Negative Regulation Of Fibroblast Migration
Endothelial Cell Morphogenesis
Skeletal System Development
Negative Regulation Of Nitric Oxide Biosynthetic Process
Hyaluronan Catabolic Process
Regulation Of Cell Migration
Negative Regulation Of Reactive Oxygen Species Biosynthetic Process
Positive Regulation Of Cell Fate Commitment
Organ Development
Regulation Of Cell Motility
Regulation Of Sprouting Angiogenesis
Negative Regulation Of Interleukin-12 Production
Regulation Of Cell Fate Specification
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Locomotion
Regulation Of Cellular Component Movement
Cell Migration Involved In Sprouting Angiogenesis
Response To Stress
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Positive Chemotaxis
Positive Regulation Of Cell Proliferation
Positive Regulation Of Cardiac Muscle Cell Proliferation
Tagcloud
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ablating
accepted
amniotes
chicken
crest
deliver
distance
dorsal
gradient
heparan
hitch
loaded
migrating
migratory
myotome
neural
onto
patterning
player
profound
proteoglycan
ride
secreted
somite
somites
tube
whereby
wnt
wnts