GPC4 and ABHD17A

Number of citations: 20 (PubMedID 21516116)
Data Source: BioGRID (two hybrid)

		GPC4	ABHD17A
Name		glypican 4	abhydrolase domain containing 17A, depalmitoylase
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Golgi Lumen Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Lysosomal Lumen Synapse Extracellular Exosome Side Of Membrane Glutamatergic Synapse	Endosome Plasma Membrane Endosome Membrane Postsynaptic Density Membrane Nuclear Speck Cell Projection Dendritic Spine Synapse Postsynaptic Membrane Recycling Endosome Membrane Postsynaptic Density Membrane Postsynaptic Recycling Endosome Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Coreceptor Activity	Protein Binding Palmitoyl-(protein) Hydrolase Activity Hydrolase Activity
	Biological Process	Regulation Of Signal Transduction Wnt Signaling Pathway Cell Migration Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Synaptic Membrane Adhesion Regulation Of Presynapse Assembly	Protein Depalmitoylation NLRP3 Inflammasome Complex Assembly Protein Localization To Membrane Regulation Of Postsynapse Organization Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Protein Localization To Microtubule Positive Regulation Of Protein Localization To Endosome
Pathways		Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions	RAS processing
GWAS		No GWAS studies recorded	No GWAS studies recorded
Novel Interactors		1 novel interactors: MX1	None recorded
Interacting Genes		10 interacting genes: ABHD17A ACP5 AKAP9 CCNC COL18A1 FGF2 PICK1 PTEN PTPRD PTPRF	14 interacting genes: BIRC2 DLG4 EHMT2 GOLGA2 GPC4 HPGDS KRTAP5-9 MDFI PLSCR4 PNMA1 RGS20 TNIP1 TRAF1 TRIM27
Entrez ID		2239	81926
HPRD ID		02160	07475
Ensembl ID		ENSG00000076716	ENSG00000129968
Uniprot IDs		O75487	Q96GS6
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Presynaptic Membrane Organization Presynaptic Membrane Assembly Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Phosphoprotein Phosphatase Activity Synaptic Membrane Adhesion Regulation Of Response To Wounding Dendritic Spine Organization Identical Protein Binding System Development Nervous System Development Neuron Projection Organization Response To Electrical Stimulus Postsynapse Organization Negative Regulation Of Superoxide Anion Generation Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Cell-cell Signaling Cell Communication Signaling Membrane Organization Postsynaptic Density Negative Regulation Of Synaptic Vesicle Clustering Membrane Assembly Chondroitin Sulfate Proteoglycan Binding Response To Stress Response To Wortmannin Positive Regulation Of Inner Ear Receptor Cell Differentiation Negative Regulation Of Wound Healing Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Cell Fate Specification Positive Regulation Of Lens Fiber Cell Differentiation Positive Regulation Of Inner Ear Auditory Receptor Cell Differentiation Neuron Projection Trans-synaptic Signaling Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Synaptic Signaling Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Regulation Of Neurogenesis Protein Dephosphorylation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Angiogenesis Involved In Coronary Vascular Morphogenesis Regulation Of Organ Growth Regulation Of Retinal Cell Programmed Cell Death Lymphatic Endothelial Cell Migration	None