SNRPB and RBM12

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		SNRPB	RBM12
Description		small nuclear ribonucleoprotein polypeptides B and B1	RNA binding motif protein 12
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP U7 SnRNP U2-type Spliceosomal Complex U1 SnRNP U2 SnRNP U4 SnRNP U12-type Spliceosomal Complex Telomerase Holoenzyme Complex Cytoplasm Cytosol Small Nuclear Ribonucleoprotein Complex Methylosome SMN-Sm Protein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Prespliceosome U2-type Precatalytic Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Histone Pre-mRNA 3'end Processing Complex Ribonucleoprotein Complex	Nucleus Nucleoplasm Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding Telomerase RNA Binding SnRNP Binding Histone Pre-mRNA DCP Binding U1 SnRNP Binding U2 SnRNP Binding	Nucleic Acid Binding RNA Binding Protein Binding
	Biological Process	Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome MRNA Processing Protein Methylation RNA Splicing 7-methylguanosine Cap Hypermethylation U2-type Prespliceosome Assembly	Regulation Of RNA Splicing
Pathways		SLBP independent Processing of Histone Pre-mRNAs snRNP Assembly mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs SARS-CoV-2 modulates host translation machinery
Drugs
Diseases
GWAS			Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		91 interacting genes: AKAP9 ASCC2 BAG4 BANP C10orf55 CALCOCO2 CD2BP2 CDKN2A CEP55 CLNS1A COA7 COG6 COIL CREM CTDP1 CYSRT1 DAB1 DDX20 DHX9 DMRTB1 ERG28 EXOSC8 FAM168B FHL3 FNBP4 GEMIN4 GEMIN5 GEMIN6 GEMIN7 GIGYF1 GIGYF2 GOLGA2 HNRNPH1 HOXA1 IL7R INCA1 KRT31 KRT34 KRT40 KRTAP19-1 KRTAP19-6 KRTAP6-1 KRTAP6-2 KRTAP6-3 L3MBTL3 LSM11 LSM8 MAGI2 MBD3L1 OIP5 OOEP PFDN5 PLEKHB2 PNMA1 PRMT5 PRMT7 PRR20A PRR20B PRR20C PRR20D PRR20E PRR22 PSMA3 RBM12 RBPMS RFX6 SERTAD3 SKIC2 SMN1 SMN2 SMNDC1 SNRPD1 SNRPD3 SNUPN SP3 SPAG8 SS18L1 STRAP STXBP2 STXBP3 TFIP11 TOP3B TRAF4 TRIM23 UBQLN2 UBXN11 USP54 WBP4 WDR77 WWP2 ZNF143	8 interacting genes: BRAP GIGYF2 OPTN PRMT2 RBFOX2 RBM10 SNRPB TBC1D4
Entrez ID		6628	10137
HPRD ID		01655	06212
Ensembl ID		ENSG00000125835	ENSG00000244462
Uniprot IDs		P14678 Q66K91	Q9NTZ6
PDB IDs		1D3B 3CW1 3JCR 3PGW 4PJO 4WZJ 5MQF 5O9Z 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6FF7 6ICZ 6ID0 6ID1 6QDV 6QW6 6QX9 6V4X 6Y53 6Y5Q 7A5P 7ABG 7ABI 7B0Y 7DVQ 7EVO 7QTT 7VPX 7W59 7W5A 7W5B 8C6J 8CH6 8H6E 8H6J 8H6K 8H6L 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8QO9 8QZS 8R08 8R09 8R0A 8R0B 8R7N 8RC0 8RM5 8RO2 8Y6O 8Y7E 9FMD 9GBW 9GC0 9GCL	1WEL 2CPY 2DNN 2EK1 2EK6
Enriched GO Terms of Interacting Partners?		Spliceosomal SnRNP Assembly SMN-Sm Protein Complex SMN Complex Protein-RNA Complex Assembly Gemini Of Cajal Bodies RNA Splicing, Via Transesterification Reactions RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome Methylosome Nuclear Body RNA Metabolic Process RNA Binding Nucleus Protein-containing Complex Assembly Protein Binding Protein-containing Complex Organization Nucleic Acid Metabolic Process Cajal Body Nucleoplasm Intermediate Filament PICln-Sm Protein Complex DNA-templated Transcription Termination Precatalytic Spliceosome Spliceosomal Complex Assembly Spliceosomal Complex Cytosol Ribonucleoprotein Complex Binding U4/U6 X U5 Tri-snRNP Complex Small Nuclear Ribonucleoprotein Complex U7 SnRNA Binding Tertiary Granule Protein-arginine Omega-N Symmetric Methyltransferase Activity Nucleobase-containing Compound Metabolic Process Identical Protein Binding U2-type Precatalytic Spliceosome U5 SnRNP Presynaptic Dense Core Vesicle Exocytosis Commitment Complex Histone H4R3 Methyltransferase Activity Peptidyl-arginine Methylation Spliceosomal Tri-snRNP Complex Neuronal Dense Core Vesicle Exocytosis Methyl-CpG Binding Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Splicing 3'-5' RNA Helicase Activity U7 SnRNP	Negative Regulation Of Cell Cycle G1/S Phase Transition Protein Methylation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Histone H3R8 Methyltransferase Activity RNA Splicing Regulation Of MRNA Metabolic Process Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Ribosomal Large Subunit Export From Nucleus Negative Regulation Of Canonical NF-kappaB Signal Transduction Nuclear Progesterone Receptor Binding MRNA Processing U2 SnRNP Binding Macromolecule Methylation Regulation Of MRNA Splicing, Via Spliceosome SnRNP Binding Smooth Muscle Cell Apoptotic Process Negative Regulation Of Signal Transduction Nucleoplasm Protein-arginine Omega-N Asymmetric Methyltransferase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Communication Negative Regulation Of Macromolecule Metabolic Process Methylation Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Signaling MRNA Splicing, Via Spliceosome RNA Binding U7 SnRNP Histone Pre-mRNA DCP Binding 7-methylguanosine Cap Hypermethylation Histone Pre-mRNA 3'end Processing Complex MRNA Metabolic Process U1 SnRNP Binding Regulation Of RNA Splicing Regulation Of Ribosome Biogenesis Regulation Of MRNA Stability Regulation Of MRNA Processing Negative Regulation Of Ribosome Biogenesis Nucleic Acid Binding Smooth Muscle Cell Proliferation Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vesicle Fusion Vesicle Positive Regulation Of Xenophagy Negative Regulation Of Receptor Recycling Type 2 Mitophagy Proximal Dendrite Negative Regulation Of Metabolic Process Negative Regulation Of Mitotic Cell Cycle
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