CYB5B and FRMD3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CYB5B	FRMD3
Description		cytochrome b5 type B	FERM domain containing 3
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle Nitric-oxide Synthase Complex	Cytoskeleton Membrane
	Molecular Function	Protein Binding Heme Binding Metal Ion Binding Nitrite Reductase (NO-forming) Activity	Protein Binding Cytoskeletal Protein Binding
	Biological Process	Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Response To Oxidative Stress	Actomyosin Structure Organization
Pathways		Sphingolipid de novo biosynthesis eNOS activation Phase I - Functionalization of compounds
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Blood osmolality (transformed sodium) ( 28360221) Blood pressure (smoking interaction) ( 25189868) Body mass index ( 26426971) Heel bone mineral density ( 30598549) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Serum uric acid levels ( 29403010 30993211)	Blood pressure traits (multi-trait analysis) ( 28498854) Hypertension ( 28498854) Insulin sensitivity index ( 24699409) Lewy body disease ( 25188341) Loneliness (multivariate analysis) ( 27629369) Metabolite levels ( 23823483)
Interacting Genes		51 interacting genes: AHNAK2 APP AQP6 BIK BNIP3L BTNL9 CD33 CD79A CGRRF1 CLDN7 CLN8 CPLX4 CREB3 EBP ERGIC3 FAM209A FAM210B FKBP7 FNDC9 FRMD3 GJB5 GPR152 IGSF9 KCNK5 KIR2DL3 LMNA MARCHF8 MFF MUC1 NDUFAF2 PDZK1IP1 PHACTR3 PLPP4 REEP4 RETREG3 SDHAF4 SLC10A1 SLC10A6 SLC16A2 SLC35H1 SLC39A9 SLC60A2 SLC71A2 STOM STX1A SYT1 TMEM139 TMEM237 TMEM35A TMEM41A TMEM86B	12 interacting genes: CMTM7 CYB5B JAGN1 NRM PLPP4 SERP1 SERP2 SLC35A4 TMEM201 TMEM218 TMEM97 ZFPL1
Entrez ID		80777	257019
HPRD ID		13106	07402
Ensembl ID		ENSG00000103018	ENSG00000172159
Uniprot IDs		O43169	A2A2Y4
PDB IDs		3NER
Enriched GO Terms of Interacting Partners?		Membrane	Membrane Nuclear Membrane Nuclear Inner Membrane Protein Localization To Extracellular Region Hormone Secretion Insulin Secretion Peptide Hormone Secretion Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Hormone Transport Endoplasmic Reticulum Unfolded Protein Response Establishment Of Protein Localization To Extracellular Region Protein Secretion Regulation Of Protein Transport Peptide Transport Peptide Secretion Positive Regulation Of Lipoprotein Transport Nitric-oxide Synthase Complex Nitrite Reductase (NO-forming) Activity Granulocyte Colony-stimulating Factor Signaling Pathway B-1a B Cell Differentiation B-1 B Cell Differentiation Pyrimidine Nucleotide-sugar Transmembrane Transporter Activity Diacylglycerol Diphosphate Phosphatase Activity Nuclear Migration Along Microtubule
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