RNF152 and GJA8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RNF152	GJA8
Description		ring finger protein 152	gap junction protein alpha 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Membrane Organelle Membrane	Plasma Membrane Gap Junction Connexin Complex Membrane Anchoring Junction
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Small GTPase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Gap Junction Channel Activity Protein Binding
	Biological Process	Protein Polyubiquitination Cytoplasmic Translation Protein Monoubiquitination Apoptotic Process Cellular Response To Starvation Positive Regulation Of Autophagy Protein Ubiquitination Cellular Response To Nutrient Levels Cellular Response To Amino Acid Starvation TORC1 Signaling Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein Localization To Lysosome Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Response To Amino Acid Starvation	Lens Development In Camera-type Eye Cell Communication Cell-cell Signaling Camera-type Eye Development Transmembrane Transport Gap Junction-mediated Intercellular Transport
Pathways		E3 ubiquitin ligases ubiquitinate target proteins	Gap junction assembly
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 30604766 31015462) Glomerular filtration rate (creatinine) ( 26831199 28452372)	Retinopathy x type 2 diabetes interaction ( 32541925) Triglyceride levels ( 34074324)
Interacting Genes		12 interacting genes: CROCC EBP GJA8 KIR2DL3 MYD88 RHEB TRAF6 TSPAN12 UBE2E1 UBE2N UBE2W UBE3A	125 interacting genes: ABL1 ACKR2 APOA2 APOD APOL3 AQP4 ARL6IP6 ATP6V0B C1GALT1 C2CD2L C3orf52 CCDC167 CCL4 CD53 CIAO2A CLDN19 CLDN4 CLEC1A CLN6 COX20 CTXN3 CXCL16 CYBC1 CYP4F2 DEFB121 DOLK ERMP1 FDFT1 FXYD6 GIMAP1 GIMAP5 GJB2 GPR108 GPR151 GPR61 GUCA2A IGFBP5 INSIG2 ITGAM KIR2DL3 LAPTM4B LAT LEPROTL1 LHFPL5 MAL MALL MARCHF2 MFSD11 MFSD6 MGST2 MIP MS4A13 NINJ2 ORMDL2 OTOP2 P2RY13 PGAP2 PLN PLP1 PMP22 PNLIPRP1 PRAF2 PROKR2 PTPRN QRFPR REEP6 RNF152 RUSF1 RXFP4 S1PR5 SCARF1 SEC22B SEC22C SEC23A SFTPC SLC13A2 SLC13A5 SLC16A12 SLC16A13 SLC16A3 SLC30A3 SLC35A4 SLC35F1 SLC35F6 SLC38A4 SLC38A7 SLC39A2 SLC39A7 SLC39A9 SLC52A1 SLC66A1 SLC66A2 SLC8A3 SMCO4 SMIM1 STX1B STX8 THSD7B TJP1 TMBIM6 TMEM100 TMEM107 TMEM121 TMEM128 TMEM147 TMEM182 TMEM239 TMEM242 TMEM243 TMEM42 TMEM45A TMEM60 TMEM65 TMEM72 TMEM86B TMEM97 TSPAN33 TWSG1 UBXN8 UNC93A UPK1B VAMP5 VAPB YIF1A YIPF6
Entrez ID		220441	2703
HPRD ID		11514	02939
Ensembl ID		ENSG00000176641	ENSG00000121634
Uniprot IDs		Q8N8N0	P48165 X5D7G1
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of TORC1 Signaling Ubiquitin-protein Transferase Activity Protein Polyubiquitination Ubiquitin Conjugating Enzyme Activity Regulation Of TOR Signaling Response To Virus Protein Monoubiquitination Interleukin-33-mediated Signaling Pathway TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity TOR Signaling Cellular Response To Nutrient Levels Antiviral Innate Immune Response Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Negative Regulation Of TOR Signaling Defense Response To Virus MyD88-dependent Toll-like Receptor Signaling Pathway Protein K48-linked Ubiquitination Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of DNA-binding Transcription Factor Activity Protein Modification By Small Protein Conjugation Positive Regulation Of Post-translational Protein Modification Endolysosomal Toll-like Receptor Signaling Pathway Interleukin-1-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Non-canonical NF-kappaB Signal Transduction Post-translational Protein Modification Regulation Of DNA-binding Transcription Factor Activity Tissue Homeostasis Anatomical Structure Homeostasis Lipopolysaccharide-mediated Signaling Pathway Response To Nutrient Levels Regulation Of Protein Ubiquitination Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway TIR Domain Binding Toll Binding ATP-dependent Histone Chaperone Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Induced Systemic Resistance Intracellular Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Sperm Entry Positive Regulation Of Golgi Lumen Acidification	Membrane Protein Binding Plasma Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Transmembrane Transport Zinc Ion Transmembrane Transporter Activity Carboxylic Acid Transmembrane Transport Organic Acid Transmembrane Transport Zinc Ion Transmembrane Transport Structural Constituent Of Myelin Sheath Zinc Ion Transport Transmembrane Transporter Activity Fumarate Transport Carboxylic Acid Transport Organic Acid Transport Sodium:dicarboxylate Symporter Activity Chemical Homeostasis Organic Anion Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Homeostatic Process Cholesterol Binding Metal Ion Transmembrane Transporter Activity Succinate Transmembrane Transporter Activity Succinate Transport Succinate Transmembrane Transport COPII-coated Vesicle Budding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?