RNF152 and UBE2W

Number of citations of the paper that reports this interaction (PubMedID 19690564)
61

Data Source:
BioGRID (two hybrid)

		RNF152	UBE2W
Description		ring finger protein 152	ubiquitin conjugating enzyme E2 W
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Membrane Organelle Membrane	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Small GTPase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination Cytoplasmic Translation Protein Monoubiquitination Apoptotic Process Cellular Response To Starvation Positive Regulation Of Autophagy Protein Ubiquitination Cellular Response To Nutrient Levels Cellular Response To Amino Acid Starvation TORC1 Signaling Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein Localization To Lysosome Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Response To Amino Acid Starvation	Protein Polyubiquitination DNA Repair Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins DNA Damage Response Protein Ubiquitination Cellular Response To Nutrient Levels TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Response To Misfolded Protein Antiviral Innate Immune Response Negative Regulation Of TORC1 Signaling
Pathways		E3 ubiquitin ligases ubiquitinate target proteins	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 30604766 31015462) Glomerular filtration rate (creatinine) ( 26831199 28452372)	Cervical high-risk human papilloma virus infection ( 33225922) Malaria ( 31844061) Manganese levels ( 26025379) Urate levels in obese individuals ( 25811787)
Interacting Genes		12 interacting genes: CROCC EBP GJA8 KIR2DL3 MYD88 RHEB TRAF6 TSPAN12 UBE2E1 UBE2N UBE2W UBE3A	81 interacting genes: AKR1C3 AMFR ARK2C ATXN3 BARD1 BFAR BIRC2 BIRC8 BRCA1 CADPS2 CBL CHFR CNOT4 DNMT3B DTX3 DTX3L DZIP3 EED FANCL LRSAM1 MAP3K1 MAPT MARCHF3 MARCHF5 MGRN1 MIB1 MID1 MKRN1 MKRN3 MUL1 PJA2 POLR2C PSTPIP1 RFWD3 RMND5B RNF10 RNF103 RNF111 RNF114 RNF123 RNF125 RNF138 RNF14 RNF150 RNF152 RNF166 RNF167 RNF183 RNF185 RNF2 RNF26 RNF31 RNF4 RNF5 RNF8 ROPN1 SNCA STUB1 TOPORS TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM3 TRIM31 TRIM35 TRIM39 TRIM5 TRIM59 TRIM7 TRIM8 UBA1 UBOX5 UFM1 UHRF2 USHBP1 XIAP ZNRF1 ZNRF2 ZNRF4
Entrez ID		220441	55284
HPRD ID		11514	07724
Ensembl ID		ENSG00000176641	ENSG00000104343
Uniprot IDs		Q8N8N0	Q96B02 Q96FI0 X6REH9
PDB IDs			2A7L 2MT6 8A58
Enriched GO Terms of Interacting Partners?		Regulation Of TORC1 Signaling Ubiquitin-protein Transferase Activity Protein Polyubiquitination Ubiquitin Conjugating Enzyme Activity Regulation Of TOR Signaling Response To Virus Protein Monoubiquitination Interleukin-33-mediated Signaling Pathway TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity TOR Signaling Cellular Response To Nutrient Levels Antiviral Innate Immune Response Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Negative Regulation Of TOR Signaling Defense Response To Virus MyD88-dependent Toll-like Receptor Signaling Pathway Protein K48-linked Ubiquitination Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of DNA-binding Transcription Factor Activity Protein Modification By Small Protein Conjugation Positive Regulation Of Post-translational Protein Modification Endolysosomal Toll-like Receptor Signaling Pathway Interleukin-1-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Non-canonical NF-kappaB Signal Transduction Post-translational Protein Modification Regulation Of DNA-binding Transcription Factor Activity Tissue Homeostasis Anatomical Structure Homeostasis Lipopolysaccharide-mediated Signaling Pathway Response To Nutrient Levels Regulation Of Protein Ubiquitination Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway TIR Domain Binding Toll Binding ATP-dependent Histone Chaperone Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Induced Systemic Resistance Intracellular Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Sperm Entry Positive Regulation Of Golgi Lumen Acidification	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Modification Process Transferase Activity Zinc Ion Binding Protein Metabolic Process Metal Ion Binding Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Protein Autoubiquitination Proteolysis Catabolic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein Catabolic Process Response To Stress Proteasomal Protein Catabolic Process Cellular Response To Stress Protein K6-linked Ubiquitination Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Protein Monoubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Cytoplasm Canonical NF-kappaB Signal Transduction Suppression Of Viral Release By Host Positive Regulation Of Catabolic Process Innate Immune Response Immune System Process DNA Damage Response Positive Regulation Of Autophagy Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To Other Organism Regulation Of Autophagy Regulation Of Signaling Regulation Of Cell Communication Regulation Of Defense Response Defense Response To Symbiont Endoplasmic Reticulum Mannose Trimming Intracellular Signal Transduction Defense Response To Other Organism Response To External Biotic Stimulus
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