SPC24 and SKA2

Number of citations of the paper that reports this interaction (PMID 22371557)
17

Data Source:
BioGRID (two hybrid)

		SPC24	SKA2
Gene Name		SPC24, NDC80 kinetochore complex component	spindle and kinetochore associated complex subunit 2
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Gene Ontology Annotations	Cellular Component	Condensed Chromosome Kinetochore Nucleus Nucleolus Cytosol Ndc80 Complex	Condensed Chromosome Outer Kinetochore Cytosol Spindle Microtubule
	Molecular Function	Protein Binding	Protein Binding Microtubule Binding
	Biological Process	Mitotic Cell Cycle Mitotic Nuclear Division Cell Division	Mitotic Cell Cycle Chromosome Segregation Mitotic Nuclear Division Regulation Of Microtubule Polymerization Or Depolymerization Cell Division
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		HDL cholesterol ( 23505323)	Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		5 interactors: APP PSEN2 SKA1 SKA2 SKA3	4 interactors: HMOX2 PRKD3 SKA1 SPC24
Entrez ID		147841	348235
HPRD ID		15464	13306
Ensembl ID			ENSG00000182628
Uniprot IDs		B4DZZ7 Q8NBT2	J3QKN8 Q8WVK7
PDB IDs		2VE7 3IZ0	4AJ5
Enriched GO Terms of Interacting Partners?		Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule-based Process Chromosome Segregation Regulation Of Epidermal Growth Factor-activated Receptor Activity Endoplasmic Reticulum Calcium Ion Homeostasis Mitotic Nuclear Division Cell Division Regulation Of Protein Tyrosine Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Regulation Of ERBB Signaling Pathway Regulation Of Cellular Component Organization Mitotic Cell Cycle Process Regulation Of Receptor Activity Mitotic Cell Cycle Notch Signaling Pathway Regulation Of Protein Binding Synaptic Growth At Neuromuscular Junction Regulation Of Organelle Organization Collateral Sprouting In Absence Of Injury Regulation Of Peptidyl-tyrosine Phosphorylation Cell Cycle Process Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Learning Or Memory Axon Choice Point Recognition Cognition Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cell Cycle Neuron Remodeling Amyloid Precursor Protein Catabolic Process Axon Guidance Regulation Of Cellular Amino Acid Metabolic Process Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Forebrain Development Cellular Ion Homeostasis Single-organism Behavior Membrane Protein Intracellular Domain Proteolysis Metal Ion Homeostasis Cellular Copper Ion Homeostasis Membrane Protein Ectodomain Proteolysis Beta-amyloid Metabolic Process Amyloid Precursor Protein Metabolic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cellular Ketone Metabolic Process	Heme Oxidation Mitotic Nuclear Division Heme Catabolic Process Cell Division Mitotic Cell Cycle Process Mitotic Cell Cycle Heme Metabolic Process Porphyrin-containing Compound Metabolic Process Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway
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