SPC24

Description		SPC24 component of NDC80 kinetochore complex
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Ndc80 Complex
	Molecular Function	Protein Binding Microtubule Binding
	Biological Process	Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Attachment Of Spindle Microtubules To Kinetochore Cell Division
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
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Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Coronary artery disease ( 33020668) Cortisol levels (saliva) ( 28843169) Haemorrhoidal disease ( 33888516) HDL cholesterol ( 23505323) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intraocular pressure ( 29617998) Lipid traits ( 24386095) Low density lipoprotein cholesterol levels ( 30718733) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Voxel-wise structural brain imaging measurements in Alzheimer’s disease ( 31095298)
Interacting Genes		7 interacting genes: APP PSEN2 SKA1 SKA2 SKA3 SUOX WHRN
Entrez ID		147841
HPRD ID		15464
Ensembl ID		ENSG00000161888
Uniprot IDs		Q8NBT2
PDB IDs		2VE7 3IZ0 8PPR 8Q5H
Enriched GO Terms of Interacting Partners?		SKA Complex Establishment Of Meiotic Spindle Orientation Establishment Of Meiotic Spindle Localization Spindle Assembly Involved In Female Meiosis Meiotic Spindle Assembly Outer Kinetochore Attachment Of Mitotic Spindle Microtubules To Kinetochore Meiotic Spindle Organization Kinetochore Mitotic Sister Chromatid Segregation Attachment Of Spindle Microtubules To Kinetochore Sister Chromatid Segregation Spindle Microtubule Establishment Of Spindle Orientation Mitotic Metaphase Chromosome Alignment Nuclear Chromosome Segregation Establishment Of Spindle Localization Metaphase Chromosome Alignment Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling Spindle Localization Chromosome Localization Positive Regulation Of Mitotic Sister Chromatid Segregation Spindle Assembly Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Mitotic Cell Cycle Meiotic Spindle Organelle Localization Chromosome Segregation Mitotic Cell Cycle Positive Regulation Of Mitotic Metaphase/anaphase Transition Spindle Organization Chromosome, Centromeric Region Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Chromosome Segregation Positive Regulation Of Chromosome Separation Spindle Establishment Of Localization In Cell Microtubule Binding Regulation Of Microtubule-based Process Establishment Of Organelle Localization Membraneless Organelle Assembly Microtubule-based Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Cell Cycle Chromosome Organization Microtubule Regulation Of Mitotic Sister Chromatid Separation Synaptic Membrane
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