MMAB and MTRR

Number of citations of the paper that reports this interaction (PubMedID 15347655)
0

Data Source:
HPRD (in vitro)

		MMAB	MTRR
Description		metabolism of cobalamin associated B	5-methyltetrahydrofolate-homocysteine methyltransferase reductase
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Nucleoplasm Cytoplasm Cytosol Intermediate Filament Cytoskeleton
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Corrinoid Adenosyltransferase Activity Transferase Activity Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Cobalamin Binding	NADPH-hemoprotein Reductase Activity Protein Binding FMN Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Metal Ions, NAD Or NADP As Acceptor [methionine Synthase] Reductase (NADPH) Activity Flavin Adenine Dinucleotide Binding NADPH Binding FAD Binding Molecular Carrier Activity
	Biological Process	Cobalamin Metabolic Process	Amino Acid Biosynthetic Process Methionine Biosynthetic Process Cobalamin Metabolic Process S-adenosylmethionine Cycle Homocysteine Catabolic Process Folic Acid Metabolic Process Homocysteine Metabolic Process
Pathways		Defective MMAB causes MMA, cblB type Cobalamin (Cbl) metabolism	Methylation Sulfur amino acid metabolism Defective MTRR causes HMAE Defective MTR causes HMAG Cobalamin (Cbl) metabolism
Drugs			Cyanocobalamin Methionine
Diseases		Methylmalonic aciduria (MMA)	Spina bifida Homocystinuria
GWAS		Age-related nuclear cataracts ( 33311586 24951543) Apolipoprotein A1 levels ( 32203549) Fish- and plant-related diet ( 32066663) HDL cholesterol ( 19060906 25961943 20864672 20686565 18193043) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 33339817) Monocyte percentage of white cells ( 32888494) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Polymyositis ( 26362759) Pork consumption ( 32066663) Red cell distribution width ( 32888494)	Capecitabine sensitivity ( 22864933) Hyperinsulinemia in lower physical activity ( 30327367) Metabolite levels ( 23823483) Verbal declarative memory ( 25648963)
Interacting Genes		2 interacting genes: CBY2 MTRR	2 interacting genes: GMCL1 MMAB
Entrez ID		326625	4552
HPRD ID		07398	03979
Ensembl ID		ENSG00000139428	ENSG00000124275
Uniprot IDs		B4DHP4 Q96EY8	Q9UBK8
PDB IDs		2IDX 6D5K 6D5X 7RUT 7RUU 7RUV	2QTL 2QTZ
Enriched GO Terms of Interacting Partners?		Oxidoreductase Activity, Acting On Metal Ions, NAD Or NADP As Acceptor [methionine Synthase] Reductase (NADPH) Activity NADPH-hemoprotein Reductase Activity S-adenosylmethionine Cycle Homocysteine Catabolic Process Methionine Biosynthetic Process FMN Binding Molecular Carrier Activity Sulfur Amino Acid Catabolic Process Homocysteine Metabolic Process Cobalamin Metabolic Process NADPH Binding Folic Acid Metabolic Process Sulfur Amino Acid Biosynthetic Process S-adenosylmethionine Metabolic Process Methionine Metabolic Process Folic Acid-containing Compound Metabolic Process Pteridine-containing Compound Metabolic Process Sulfur Amino Acid Metabolic Process FAD Binding Aspartate Family Amino Acid Metabolic Process Intermediate Filament Cytoskeleton Tetrapyrrole Metabolic Process Amino Acid Biosynthetic Process Flavin Adenine Dinucleotide Binding Dicarboxylic Acid Metabolic Process Sulfur Compound Biosynthetic Process Amino Acid Catabolic Process Modified Amino Acid Metabolic Process L-amino Acid Metabolic Process Alpha-amino Acid Metabolic Process Carboxylic Acid Catabolic Process Sulfur Compound Metabolic Process Carboxylic Acid Biosynthetic Process Amino Acid Metabolic Process	Flavin-dependent Sulfhydryl Oxidase Activity Mitochondrial Disulfide Relay System Corrinoid Adenosyltransferase Activity Thiol Oxidase Activity Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Cobalamin Binding Cobalamin Metabolic Process Protein-disulfide Reductase Activity
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