PATL1 and LSM2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, proximity labelling technology)

		PATL1	LSM2
Description		PAT1 homolog 1, processing body mRNA decay factor	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
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GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol PML Body Nuclear Speck CCR4-NOT Complex Cytoplasmic Ribonucleoprotein Granule	P-body Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP Cytoplasm Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Lsm2-8 Complex Lsm1-7-Pat1 Complex Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding Poly(U) RNA Binding Poly(G) Binding	RNA Binding Protein Binding U6 SnRNA Binding Small GTPase Binding
	Biological Process	Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA P-body Assembly	Spliceosomal Tri-snRNP Complex Assembly MRNA Splicing, Via Spliceosome MRNA Processing MRNA Catabolic Process RNA Splicing
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Inflammatory bowel disease ( 28067908) Rosacea symptom severity ( 29771307) Ulcerative colitis ( 28067908)
Interacting Genes		25 interacting genes: APP CLK2 DMRTB1 FHL3 GOLGA2 KRT31 KRTAP6-2 LSM2 LSM6 MIR1-2 MIR138-2 MIR15B MIR19B1 MIR19B2 MIR20B MIR21 MIR25 MIR29B2 NFKBID PSMA3 RBPMS SNCA TSC1 WWOX ZMYND12	39 interacting genes: BANP CBX8 CEBPA CRMP1 DNAAF11 DNAJA1 ERG28 EXOSC10 GBP2 KRT13 LGALS7 LGALS7B LNX1 LSM1 LSM12 LSM3 LSM5 LSM6 LSM7 LSM8 LZTS1 MAGEA3 MAGEA6 MEOX2 PATL1 PCM1 PNMA1 RALA REL RSRC1 SF3B2 SMN1 SNRPD2 SNRPE TEX11 TLE5 TRIM54 ZBTB16 ZNF408
Entrez ID		219988	57819
HPRD ID		08214	06282
Ensembl ID		ENSG00000166889	ENSG00000204392
Uniprot IDs		Q86TB9	Q9Y333
PDB IDs		2XEQ 2XER 2XES	3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Extracellular Vesicle Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of Macromolecule Metabolic Process MRNA 3'-UTR Binding Lsm2-8 Complex MiRNA-mediated Gene Silencing By Inhibition Of Translation U6 SnRNP Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of T-helper 17 Cell Differentiation Negative Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Negative Regulation Of Endothelial Cell Migration Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Vascular Endothelial Growth Factor Production Adult Locomotory Behavior Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Protein Tetramerization Regulation Of Inflammatory Response Positive Regulation Of T-helper 17 Type Immune Response Regulation Of Neurotransmitter Uptake P-body Negative Regulation Of Smooth Muscle Cell Differentiation Regulation Of Non-canonical NF-kappaB Signal Transduction Cellular Response To Copper Ion Negative Regulation Of Autophagy Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of T-helper Cell Differentiation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Calcium Ion Transmembrane Transport	U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions Lsm2-8 Complex U4/U6 X U5 Tri-snRNP Complex U6 SnRNP Lsm1-7-Pat1 Complex RNA Splicing MRNA Metabolic Process MRNA Splicing, Via Spliceosome Precatalytic Spliceosome MRNA Processing Spliceosomal Complex RNA Processing U12-type Spliceosomal Complex MRNA Catabolic Process RNA Metabolic Process Catalytic Step 2 Spliceosome Ribonucleoprotein Complex RNA Binding Spliceosomal Complex Assembly RNA Catabolic Process Small Nuclear Ribonucleoprotein Complex SMN-Sm Protein Complex Nucleus Nucleic Acid Metabolic Process U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex Nucleobase-containing Compound Metabolic Process P-body PICln-Sm Protein Complex Nuclear-transcribed MRNA Catabolic Process Nucleobase-containing Compound Catabolic Process Spliceosomal SnRNP Assembly 7-methylguanosine Cap Hypermethylation U4 SnRNP Methylosome Nuclear Speck Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA U6 SnRNA Binding Histone MRNA Catabolic Process P-body Assembly Negative Regulation Of Metabolic Process MRNA Methylguanosine-cap Decapping Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression U1 SnRNP U5 SnRNP RNA Decapping Protein Binding
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