PATL1 and LSM6

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology)

		PATL1	LSM6
Description		PAT1 homolog 1, processing body mRNA decay factor	LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
Image
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol PML Body Nuclear Speck CCR4-NOT Complex Cytoplasmic Ribonucleoprotein Granule	P-body Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP Nucleolus Sno(s)RNA-containing Ribonucleoprotein Complex Cytoplasm Cytosol Small Nuclear Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Lsm2-8 Complex Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding Poly(U) RNA Binding Poly(G) Binding	RNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA P-body Assembly	MRNA Splicing, Via Spliceosome RRNA Processing MRNA Processing MRNA Catabolic Process TRNA Processing RNA Splicing Maturation Of SSU-rRNA
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs			Uridine Uridine monophosphate Citric acid
Diseases
GWAS			Malaria ( 31844061) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415)
Interacting Genes		25 interacting genes: APP CLK2 DMRTB1 FHL3 GOLGA2 KRT31 KRTAP6-2 LSM2 LSM6 MIR1-2 MIR138-2 MIR15B MIR19B1 MIR19B2 MIR20B MIR21 MIR25 MIR29B2 NFKBID PSMA3 RBPMS SNCA TSC1 WWOX ZMYND12	16 interacting genes: APP CEBPA LSM1 LSM2 LSM3 LSM5 LSM7 LSM8 MCRS1 PATL1 POLD2 SDCBP SMN1 SNRPD2 SNRPF TARDBP
Entrez ID		219988	11157
HPRD ID		08214	06286
Ensembl ID		ENSG00000166889	ENSG00000164167
Uniprot IDs		Q86TB9	P62312
PDB IDs		2XEQ 2XER 2XES	3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Extracellular Vesicle Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of Macromolecule Metabolic Process MRNA 3'-UTR Binding Lsm2-8 Complex MiRNA-mediated Gene Silencing By Inhibition Of Translation U6 SnRNP Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of T-helper 17 Cell Differentiation Negative Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Negative Regulation Of Endothelial Cell Migration Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Vascular Endothelial Growth Factor Production Adult Locomotory Behavior Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Protein Tetramerization Regulation Of Inflammatory Response Positive Regulation Of T-helper 17 Type Immune Response Regulation Of Neurotransmitter Uptake P-body Negative Regulation Of Smooth Muscle Cell Differentiation Regulation Of Non-canonical NF-kappaB Signal Transduction Cellular Response To Copper Ion Negative Regulation Of Autophagy Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of T-helper Cell Differentiation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Calcium Ion Transmembrane Transport	Lsm1-7-Pat1 Complex U4/U6 X U5 Tri-snRNP Complex Lsm2-8 Complex U2-type Precatalytic Spliceosome U6 SnRNP RNA Splicing, Via Transesterification Reactions RNA Splicing MRNA Metabolic Process MRNA Processing Nucleic Acid Metabolic Process RNA Metabolic Process Spliceosomal Complex Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Processing Ribonucleoprotein Complex Precatalytic Spliceosome RNA Binding Catalytic Step 2 Spliceosome Macromolecule Metabolic Process Spliceosomal SnRNP Assembly MRNA Catabolic Process Nucleus U6 SnRNA Binding SMN-Sm Protein Complex RNA Catabolic Process Nucleoplasm U12-type Spliceosomal Complex P-body Spliceosomal Complex Assembly PICln-Sm Protein Complex Nucleobase-containing Compound Catabolic Process Negative Regulation Of Macromolecule Metabolic Process 7-methylguanosine Cap Hypermethylation Poly(G) Binding Protein-RNA Complex Assembly Negative Regulation Of Gene Expression Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process U4 SnRNP Methylosome Negative Regulation Of Biosynthetic Process Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA P-body Assembly Small Nuclear Ribonucleoprotein Complex MRNA Methylguanosine-cap Decapping Nuclear-transcribed MRNA Catabolic Process U1 SnRNP U5 SnRNP RNA Decapping
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