VSIR and C14orf180

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VSIR	C14orf180
Description		V-set immunoregulatory receptor	chromosome 14 open reading frame 180
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Binding Enzyme Binding Identical Protein Binding Endopeptidase Activator Activity	Protein Binding
	Biological Process	Positive Regulation Of Gene Expression Positive Regulation Of Endopeptidase Activity Positive Regulation Of Cell Migration Zymogen Activation Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Activation Regulation Of Immune Response Positive Regulation Of Collagen Catabolic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Negative Regulation Of CD8-positive, Alpha-beta T Cell Proliferation
Pathways
Drugs
Diseases
GWAS			Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Rheumatoid arthritis ( 30891314)
Interacting Genes		27 interacting genes: APOD ASGR1 ATP6V0C BMP10 C14orf180 CCL4L2 CLEC7A CLRN2 CNIH3 DOLK MS4A13 PLPP6 PLPPR2 PLSCR1 SLC35B1 SLC35B4 SMAD3 SMCO4 TMEM100 TMEM14C TMEM218 TMEM229B TMEM97 TNF TSPAN2 TSPO2 VAMP3	47 interacting genes: AQP3 AQP6 ARL13B ASZ1 BIK CD74 CD79A CISD2 CLEC7A CPLX4 CYBC1 EBAG9 ERGIC3 FAM174A FAM209A GPR152 GPRC5D GPX8 HAS3 KASH5 KCNJ6 LHFPL5 LIME1 MFF MGST3 MUC1 NCR3LG1 PDZK1IP1 PPP1CB PPP1CC REEP4 SAR1A SLC10A6 SLC35H1 SLC71A2 TEX29 TIMMDC1 TM4SF19 TMEM106C TMEM14B TMEM167B TMEM207 TMEM31 TMEM51 TMEM80 VSIR ZDHHC15
Entrez ID		64115	400258
HPRD ID		15160	17383
Ensembl ID		ENSG00000107738	ENSG00000184601
Uniprot IDs		Q9H7M9	B4DN93 J3KNP8 Q8N912
PDB IDs		6MVL 6OIL 6U6V 8TBQ
Enriched GO Terms of Interacting Partners?		Membrane Positive Regulation Of Neutrophil Activation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Cholesterol Binding Plasma Membrane Regulation Of Wound Healing Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Production Regulation Of Neutrophil Activation Nucleotide-sugar Transmembrane Transport Pyrimidine Nucleotide-sugar Transmembrane Transport Regulation Of Response To Wounding Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Interleukin-1 Production Phosphatidate Phosphatase Activity Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Chemokine Production Regulation Of Interleukin-1 Beta Production Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of MiRNA Transcription Positive Regulation Of Cartilage Development Regulation Of Interleukin-1 Production Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Activin Receptor Signaling Pathway Organophosphate Ester Transport Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of Cytokine Production Involved In Inflammatory Response Dolichol Kinase Activity Detection Of Yeast Detection Of Molecule Of Fungal Origin Phospholipid Dephosphorylation UDP-xylose Transmembrane Transport UDP-xylose Transmembrane Transporter Activity 5-aminolevulinic Acid Import Across Plasma Membrane 5-aminolevulinic Acid Transmembrane Transporter Activity Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process Negative Regulation Of Cardiac Muscle Hypertrophy	Membrane Protein Binding B Cell Receptor Complex PTW/PP1 Phosphatase Complex
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