VSIR and TMEM100

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VSIR	TMEM100
Description		V-set immunoregulatory receptor	transmembrane protein 100
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Cytoplasm Endoplasmic Reticulum Plasma Membrane Membrane Perikaryon Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Enzyme Binding Identical Protein Binding Endopeptidase Activator Activity	Protein Binding
	Biological Process	Positive Regulation Of Gene Expression Positive Regulation Of Endopeptidase Activity Positive Regulation Of Cell Migration Zymogen Activation Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Activation Regulation Of Immune Response Positive Regulation Of Collagen Catabolic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Negative Regulation Of CD8-positive, Alpha-beta T Cell Proliferation	Angiogenesis Vasculogenesis In Utero Embryonic Development Endocardial Cushion Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Notch Signaling Pathway Cell Differentiation BMP Signaling Pathway Positive Regulation Of Endothelial Cell Differentiation Regulation Of Calcium-mediated Signaling Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Sensory Perception Of Pain Arterial Endothelial Cell Differentiation Cellular Response To BMP Stimulus Positive Regulation Of Vasculogenesis
Pathways
Drugs
Diseases
GWAS			Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856) Height ( 22021425) Pulse pressure ( 30578418) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		27 interacting genes: APOD ASGR1 ATP6V0C BMP10 C14orf180 CCL4L2 CLEC7A CLRN2 CNIH3 DOLK MS4A13 PLPP6 PLPPR2 PLSCR1 SLC35B1 SLC35B4 SMAD3 SMCO4 TMEM100 TMEM14C TMEM218 TMEM229B TMEM97 TNF TSPAN2 TSPO2 VAMP3	33 interacting genes: AQP6 CCDC57 CD33 CLDN7 COMT CREB3 EBP ERGIC3 F11R FAM209A FNDC9 GJA8 GPR152 HSD17B13 IFNGR1 JAGN1 LHFPL5 MEOX2 NUP93 REEP1 RETREG3 RMDN3 RNF19B SLC30A4 SLC35A5 STING1 STX1A TMEM130 TMEM167B TMEM52B TMEM79 TMEM80 VSIR
Entrez ID		64115	55273
HPRD ID		15160	07719
Ensembl ID		ENSG00000107738	ENSG00000166292
Uniprot IDs		Q9H7M9	Q9NV29
PDB IDs		6MVL 6OIL 6U6V 8TBQ
Enriched GO Terms of Interacting Partners?		Membrane Positive Regulation Of Neutrophil Activation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Cholesterol Binding Plasma Membrane Regulation Of Wound Healing Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Production Regulation Of Neutrophil Activation Nucleotide-sugar Transmembrane Transport Pyrimidine Nucleotide-sugar Transmembrane Transport Regulation Of Response To Wounding Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Interleukin-1 Production Phosphatidate Phosphatase Activity Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Chemokine Production Regulation Of Interleukin-1 Beta Production Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of MiRNA Transcription Positive Regulation Of Cartilage Development Regulation Of Interleukin-1 Production Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Activin Receptor Signaling Pathway Organophosphate Ester Transport Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of Cytokine Production Involved In Inflammatory Response Dolichol Kinase Activity Detection Of Yeast Detection Of Molecule Of Fungal Origin Phospholipid Dephosphorylation UDP-xylose Transmembrane Transport UDP-xylose Transmembrane Transporter Activity 5-aminolevulinic Acid Import Across Plasma Membrane 5-aminolevulinic Acid Transmembrane Transporter Activity Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process Negative Regulation Of Cardiac Muscle Hypertrophy	Membrane
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