VSIR and CNIH3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VSIR	CNIH3
Description		V-set immunoregulatory receptor	cornichon family AMPA receptor auxiliary protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Endoplasmic Reticulum Membrane Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Dendrite AMPA Glutamate Receptor Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Dendritic Shaft Synapse Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Enzyme Binding Identical Protein Binding Endopeptidase Activator Activity	Signaling Receptor Binding Protein Binding Channel Regulator Activity
	Biological Process	Positive Regulation Of Gene Expression Positive Regulation Of Endopeptidase Activity Positive Regulation Of Cell Migration Zymogen Activation Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Activation Regulation Of Immune Response Positive Regulation Of Collagen Catabolic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Negative Regulation Of CD8-positive, Alpha-beta T Cell Proliferation	Vesicle-mediated Transport Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of AMPA Receptor Activity
Pathways			COPII-mediated vesicle transport Cargo concentration in the ER
Drugs
Diseases
GWAS			Cancer ( 29299148) Gut microbiota relative abundance (Streptococcus) ( 33208821) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin ( 32888494) Neonatal white matter microstructure ( 33009551) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Opioid dependence ( 26239289) White blood cell count ( 32888494)
Interacting Genes		27 interacting genes: APOD ASGR1 ATP6V0C BMP10 C14orf180 CCL4L2 CLEC7A CLRN2 CNIH3 DOLK MS4A13 PLPP6 PLPPR2 PLSCR1 SLC35B1 SLC35B4 SMAD3 SMCO4 TMEM100 TMEM14C TMEM218 TMEM229B TMEM97 TNF TSPAN2 TSPO2 VAMP3	28 interacting genes: AQP6 BIK CD79A CEACAM3 CLDN20 ERGIC3 FAM210B FNDC9 GPX8 KCNN4 LEUTX LMNA LRRC25 NEMP1 ODF4 PLD3 SLC16A2 SMIM3 SORT1 STOM SUSD3 TMEM14B TMEM237 TMEM31 TMEM52B TMEM80 TMPRSS2 VSIR
Entrez ID		64115	149111
HPRD ID		15160	08799
Ensembl ID		ENSG00000107738	ENSG00000143786
Uniprot IDs		Q9H7M9	Q8TBE1
PDB IDs		6MVL 6OIL 6U6V 8TBQ
Enriched GO Terms of Interacting Partners?		Membrane Positive Regulation Of Neutrophil Activation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Cholesterol Binding Plasma Membrane Regulation Of Wound Healing Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Production Regulation Of Neutrophil Activation Nucleotide-sugar Transmembrane Transport Pyrimidine Nucleotide-sugar Transmembrane Transport Regulation Of Response To Wounding Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Interleukin-1 Production Phosphatidate Phosphatase Activity Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Chemokine Production Regulation Of Interleukin-1 Beta Production Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of MiRNA Transcription Positive Regulation Of Cartilage Development Regulation Of Interleukin-1 Production Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Activin Receptor Signaling Pathway Organophosphate Ester Transport Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of Cytokine Production Involved In Inflammatory Response Dolichol Kinase Activity Detection Of Yeast Detection Of Molecule Of Fungal Origin Phospholipid Dephosphorylation UDP-xylose Transmembrane Transport UDP-xylose Transmembrane Transporter Activity 5-aminolevulinic Acid Import Across Plasma Membrane 5-aminolevulinic Acid Transmembrane Transporter Activity Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process Negative Regulation Of Cardiac Muscle Hypertrophy	Membrane
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