FAM241B and TRHR

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		FAM241B	TRHR
Name		family with sequence similarity 241 member B	thyrotropin releasing hormone receptor
Structure		No pdb structure
GO Annotations	Cellular Component	Membrane Intracellular Membrane-bounded Organelle	Plasma Membrane Membrane
	Molecular Function	Protein Binding	G Protein-coupled Receptor Activity Thyrotropin-releasing Hormone Receptor Activity Protein Binding
	Biological Process	None	Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Pathways		None	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs		None	Protirelin
GWAS		Type 2 diabetes ( 30054458 )	Body mass (lean) ( 19268274 ) Daytime sleep phenotypes ( 27126917 ) LDL cholesterol levels ( 32203549 ) Night sleep phenotypes ( 27126917 ) Pulse pressure ( 30224653 ) Type 2 diabetes ( 30297969 )
Interacting Genes		27 interacting genes: ADRA1A BIK BLCAP BNIP3 CD79A CGRRF1 CISD2 ERBB2 ERBB3 ERBB4 HSD17B11 KASH5 MOSPD1 MTNR1A REEP4 RNF185 RNF5 SCN3B SLC10A1 SLC39A11 SLC7A1 SUSD6 SYNE4 TMEM234 TMX2 TRHR ZDHHC15	19 interacting genes: ARRB1 C1QL4 COMT EFNA5 FAM241B FXYD6-FXYD2 GJB2 IER3IP1 NIPAL4 PEDS1-UBE2V1 SLC39A2 SLC39A9 SLC41A1 TMEFF2 TMEM218 TMEM239 TRH UBE2J1 YIPF6
Entrez ID		219738	7201
HPRD ID		12573	11767
Ensembl ID		ENSG00000171224	ENSG00000174417
Uniprot IDs		Q96D05	P34981
PDB IDs		Not available	7WKD 7X1T 7X1U 7XW9
GO Terms Enriched among Interactors		Membrane ERBB3:ERBB2 Complex Basal Plasma Membrane ERBB2 Signaling Pathway Neuregulin Receptor Activity Protein Localization To Postsynapse ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Basolateral Plasma Membrane Ubiquitin-like Protein Conjugating Enzyme Binding Endoplasmic Reticulum ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Mitochondrial Fragmentation Involved In Apoptotic Process Protein Localization To Synapse Meiotic Nuclear Membrane Microtubule Tethering Complex Epidermal Growth Factor Receptor Signaling Pathway Apoptotic Mitochondrial Changes Mitochondrial Membrane Endoplasmic Reticulum Mannose Trimming Receptor Complex ERBB Signaling Pathway Protein Localization To Cell Junction Protein Alpha-1,2-demannosylation Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Protein Deglycosylation Glial Cell Differentiation Endoplasmic Reticulum Quality Control Compartment Positive Regulation Of Release Of Cytochrome C From Mitochondria Peripheral Nervous System Development Heart Development Positive Regulation Of Heart Rate Endoplasmic Reticulum Membrane Protein Tyrosine Kinase Activity Nuclear Outer Membrane Protein Localization To Postsynaptic Membrane Protein Localization To Membrane Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Positive Regulation Of Heart Contraction Mitochondrion Autophagosome Adaptor Activity Establishment Of Planar Polarity Involved In Nephron Morphogenesis Thyrotropin-releasing Hormone Receptor Activity Regulation Of Release Of Cytochrome C From Mitochondria Oligodendrocyte Differentiation Apoptotic Process Growth Factor Binding Cell Death Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine	Magnesium Ion Transport Magnesium Ion Transmembrane Transport Magnesium Ion Transmembrane Transporter Activity Zinc Ion Transport Zinc Ion Transmembrane Transporter Activity Metal Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transport