FAM241B and TMX2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FAM241B	TMX2
Description		family with sequence similarity 241 member B	thioredoxin related transmembrane protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Membrane Intracellular Membrane-bounded Organelle	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondrial Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site
	Molecular Function	Protein Binding	Protein Binding Disulfide Oxidoreductase Activity Identical Protein Binding
	Biological Process		Brain Development
Pathways
Drugs
Diseases
GWAS		Type 2 diabetes ( 30054458)	Autism spectrum disorder or schizophrenia ( 28540026) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Neuroticism ( 29255261) Problematic alcohol use ( 32451486) Reticulocyte count ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		27 interacting genes: ADRA1A BIK BLCAP BNIP3 CD79A CGRRF1 CISD2 ERBB2 ERBB3 ERBB4 HSD17B11 KASH5 MOSPD1 MTNR1A REEP4 RNF185 RNF5 SCN3B SLC10A1 SLC39A11 SLC7A1 SUSD6 SYNE4 TMEM234 TMX2 TRHR ZDHHC15	163 interacting genes: AGPAT3 AGPAT4 AGPAT5 AIG1 AQP6 ARV1 ASGR1 ASPH ATXN1 BDKRB1 BET1 BNIP1 BNIP2 BNIP3 BRICD5 BTN2A2 C2CD2L CCDC167 CCL2 CD81 CDIPT CDS2 CMTM7 COL8A2 COMMD8 COX20 CTSA CTXN3 CXCL16 CXorf66 CYBC1 CYP4F2 DERL1 DGAT2L6 EMD EMP3 F2RL1 FA2H FAM177A1 FAM241B FAM3C FAXDC2 FDFT1 FUNDC2 FXYD6-FXYD2 GIMAP1 GIMAP5 GJB2 HACD2 HHATL HMOX1 HMOX2 HSD17B11 HSD17B13 HTATIP2 IER3 IER3IP1 IGFBP5 INSIG2 ITGAM LEPROT LEPROTL1 LHFPL5 LRAT MALL MFF MGLL MGST3 MIP MLN MS4A1 MTNR1A NAT8 NDUFA3 NINJ2 NRM NSDHL NSG1 ORMDL2 OTULINL PAEP PEDS1-UBE2V1 PEX16 PKMYT1 PLP2 PNLIPRP1 PRAF2 PRB1 PTAFR PTPN9 RABAC1 REEP2 REEP4 RFT1 RNF24 RTP2 RUSF1 SACM1L SCAMP5 SCD SELENOK SERF1A SERF1B SERP2 SFT2D1 SFXN1 SFXN3 SLC22A2 SLC29A2 SLC35A1 SLC67A1 SLC71A2 SMAGP SMCO4 SMIM1 STATH STX12 STX3 STX7 THBD THSD7B TMBIM6 TMEM115 TMEM120A TMEM120B TMEM121 TMEM128 TMEM140 TMEM14B TMEM14C TMEM176A TMEM201 TMEM203 TMEM208 TMEM222 TMEM239 TMEM254 TMEM31 TMEM50B TMEM51 TMEM65 TMEM71 TMEM86B TMEM97 TPRG1 TRAM1L1 TREX1 TSNARE1 TSPAN2 TVP23B UBE2J1 UNC93A VAMP1 VAMP3 VAMP4 VAMP5 VAPA VAPB WFDC2 YIF1A YIPF1 YIPF2 YIPF6
Entrez ID		219738	51075
HPRD ID		12573	07159
Ensembl ID		ENSG00000171224	ENSG00000213593
Uniprot IDs		Q96D05	Q9Y320
PDB IDs			2DJ0
Enriched GO Terms of Interacting Partners?		Membrane ERBB3:ERBB2 Complex Basal Plasma Membrane ERBB2 Signaling Pathway Neuregulin Receptor Activity Protein Localization To Postsynapse ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Basolateral Plasma Membrane Ubiquitin-like Protein Conjugating Enzyme Binding Endoplasmic Reticulum ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Mitochondrial Fragmentation Involved In Apoptotic Process Protein Localization To Synapse Meiotic Nuclear Membrane Microtubule Tethering Complex Epidermal Growth Factor Receptor Signaling Pathway Apoptotic Mitochondrial Changes Mitochondrial Membrane Endoplasmic Reticulum Mannose Trimming Receptor Complex ERBB Signaling Pathway Protein Localization To Cell Junction Protein Alpha-1,2-demannosylation Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Protein Deglycosylation Glial Cell Differentiation Endoplasmic Reticulum Quality Control Compartment Positive Regulation Of Release Of Cytochrome C From Mitochondria Peripheral Nervous System Development Heart Development Positive Regulation Of Heart Rate Endoplasmic Reticulum Membrane Protein Tyrosine Kinase Activity Nuclear Outer Membrane Protein Localization To Postsynaptic Membrane Protein Localization To Membrane Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Positive Regulation Of Heart Contraction Mitochondrion Autophagosome Adaptor Activity Establishment Of Planar Polarity Involved In Nephron Morphogenesis Thyrotropin-releasing Hormone Receptor Activity Regulation Of Release Of Cytochrome C From Mitochondria Oligodendrocyte Differentiation Apoptotic Process Growth Factor Binding Cell Death Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNARE Complex SNAP Receptor Activity Cortical Endoplasmic Reticulum Protein Binding CDP-diacylglycerol Metabolic Process Vesicle-mediated Transport Lipid Biosynthetic Process Membrane Organization Nuclear Envelope Endomembrane System Membrane Docking CDP-diacylglycerol Biosynthetic Process Organelle Fusion Organelle Membrane Fusion Intracellular Transport Lipid Metabolic Process Organelle Localization By Membrane Tethering Golgi Membrane Membrane Fusion Endoplasmic Reticulum Organization Cellular Localization Establishment Of Localization In Cell Sterol Biosynthetic Process Vesicle Fusion Golgi Trans Cisterna Golgi Medial Cisterna Golgi Vesicle Transport Heme Oxidation Heme Oxygenase (decyclizing) Activity Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Nuclear Inner Membrane Response To Oxygen-glucose Deprivation Regulation Of Cellular Localization Amyloid Fibril Formation Mitochondrial Outer Membrane Steroid Biosynthetic Process Monoatomic Ion Transmembrane Transporter Activity SNARE Complex Assembly Glycerolipid Metabolic Process FFAT Motif Binding Steroid Dehydrogenase Activity Serine Import Into Mitochondrion Vesicle Docking Golgi Apparatus Heme Metabolic Process Spindle Pole Centrosome Cholesterol Biosynthetic Process
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