NEDD1

Description		NEDD1 gamma-tubulin ring complex targeting factor
Image		No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Spindle Pole Fibrillar Center Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Ciliary Basal Body Apical Part Of Cell
	Molecular Function	Protein Binding Gamma-tubulin Binding
	Biological Process	Mitotic Cell Cycle Microtubule Nucleation Cell Division
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Autism ( 24189344) Breast size ( 22747683) Cerebral amyloid angiopathy in Alzheimer’s disease ( 34020725) Frontotemporal dementia ( 29724592) Frontotemporal dementia with GRN mutation ( 29724592) joint destruction in rheumatoid arthritis (rapid vs slow) ( 33585033) Manganese levels ( 26025379) Obstructive sleep apnea (BMI adjusted) ( 33243845)
Interacting Genes		6 interacting genes: CDK1 CEBPA EP300 FBLN1 PLK1 RND1
Entrez ID		121441
HPRD ID		02655
Ensembl ID		ENSG00000139350
Uniprot IDs		A8K1Z3 Q8NHV4
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitotic Nuclear Membrane Disassembly Protein Localization To Chromosome Positive Regulation Of Protein Localization To Nucleus STAT Family Protein Binding Membrane Disassembly Nuclear Membrane Disassembly Regulation Of Protein Localization To Nucleus Protein Localization To Site Of Double-strand Break Negative Regulation Of Stem Cell Proliferation Mitotic G2 DNA Damage Checkpoint Signaling Intracellular Signal Transduction Spindle Microtubule Chromosome Condensation Intracellular Signaling Cassette Positive Regulation Of Protein Import Into Nucleus Nuclear Membrane Organization Centrosome Cycle Mitotic G2/M Transition Checkpoint G2/M Transition Of Mitotic Cell Cycle Protein Localization To Chromatin Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Import Into Nucleus Protein Destabilization Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Cell Cycle G2/M Phase Transition Pronuclear Fusion Positive Regulation Of Gene Expression Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Biosynthetic Process Regulation Of Organelle Organization Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Signal Transduction Positive Regulation Of Protein Localization Mitotic DNA Damage Checkpoint Signaling Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Microtubule Organizing Center Organization Regulation Of Stem Cell Proliferation Negative Regulation Of Macromolecule Metabolic Process Chromatin DNA Binding
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