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F12 and UBE2E1
Number of citations of the paper that reports this interaction (PubMedID
18838541
)
51
Data Source:
BioGRID
(pull down)
F12
UBE2E1
Description
coagulation factor XII
ubiquitin conjugating enzyme E2 E1
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Rough Endoplasmic Reticulum
Plasma Membrane
Extracellular Matrix
Extracellular Exosome
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytosol
Molecular Function
Serine-type Endopeptidase Activity
Calcium Ion Binding
Protein Binding
Peptidase Activity
Serine-type Peptidase Activity
Hydrolase Activity
Misfolded Protein Binding
Nucleotide Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Transferase Activity
ISG15 Transferase Activity
Ubiquitin Conjugating Enzyme Activity
Biological Process
Plasma Kallikrein-kinin Cascade
Factor XII Activation
Proteolysis
Blood Coagulation
Blood Coagulation, Intrinsic Pathway
Hemostasis
Positive Regulation Of Plasminogen Activation
Protein Processing
Protein Autoprocessing
Positive Regulation Of Blood Coagulation
Zymogen Activation
Fibrinolysis
Innate Immune Response
Response To Misfolded Protein
Positive Regulation Of Fibrinolysis
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Negative Regulation Of Gene Expression
Protein Ubiquitination
ISG15-protein Conjugation
Positive Regulation Of Transcription By RNA Polymerase II
Protein K48-linked Ubiquitination
Pathways
Intrinsic Pathway of Fibrin Clot Formation
Defective factor XII causes hereditary angioedema
Defective SERPING1 causes hereditary angioedema
ISG15 antiviral mechanism
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
Assembly of the pre-replicative complex
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Zinc
Human C1-esterase inhibitor
Ethanolamine oleate
Conestat alfa
Nafamostat
Zinc acetate
Diseases
Hereditary angioedema
Factor XII deficiency; Hageman factor deficiency
GWAS
Activated partial thromboplastin time (
22703881
20303064
29403010
)
Cardiac troponin-I levels (
31014085
)
Chronic kidney disease (
20383146
)
Circulating chromogranin peptide levels (
28011710
)
Circulating vasoactive peptide levels (
23381795
)
Glycine levels (
30837465
)
L-arginine levels (
27656708
)
Metabolite levels (
22286219
22916037
)
Nephrolithiasis (
22396660
)
Platelet function and related traits (
21546496
)
Serum metabolite levels (
33031748
)
Tinnitus (
33742053
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI (age <50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Academic attainment (English) (
33594131
)
Acne (severe) (
24927181
)
Extremely high intelligence (
29520040
)
Metabolite levels (
23823483
)
Interacting Genes
16 interacting genes:
APOH
APP
CD93
EPAS1
GP1BA
HIF1A
KLKB1
KRT1
MMP12
MMP13
MMP14
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2N
116 interacting genes:
ARIH2
ARK2C
ASXL2
BARD1
BIRC7
BIRC8
BRCA1
CADPS2
CBL
CHFR
CNOT4
CUL3
DTX1
DTX3
DTX3L
DZIP3
EPS15
F12
FBXO2
FBXO7
HDAC6
IPO11
ITCH
JADE1
LRSAM1
MAP3K1
MARCHF2
MARCHF3
MARCHF5
MARCHF7
MDM2
MGRN1
MID1
MKRN3
MUL1
NEDD4
NEDD4L
NHLRC1
PAEP
PBX2
POLL
POLM
PRKN
RBX1
RELA
RFWD3
RLIM
RMND5B
RNF10
RNF103
RNF11
RNF111
RNF114
RNF115
RNF122
RNF128
RNF13
RNF130
RNF14
RNF150
RNF152
RNF166
RNF167
RNF168
RNF169
RNF181
RNF185
RNF2
RNF20
RNF26
RNF31
RNF34
RNF4
RNF43
RNF5
RNF8
STUB1
TOPORS
TRAF6
TRIM13
TRIM17
TRIM2
TRIM21
TRIM23
TRIM27
TRIM28
TRIM29
TRIM3
TRIM32
TRIM33
TRIM37
TRIM38
TRIM39
TRIM45
TRIM50
TRIM69
TRIM7
UBA1
UBA6
UBA7
UBASH3B
UBC
UBE2G1
UBE3A
UBOX5
UBR5
UBR7
UFM1
USP7
UVSSA
WWP2
XIAP
ZNG1E
ZNRF1
ZNRF2
ZNRF4
Entrez ID
2161
7324
HPRD ID
01992
04225
Ensembl ID
ENSG00000131187
ENSG00000170142
Uniprot IDs
P00748
Q8IZZ5
B7Z306
P51965
PDB IDs
4BDW
4BDX
4XDE
4XE4
6B74
6B77
6GT6
6L63
6QF7
6SZW
6X0S
6X0T
7FBP
7PRJ
7PRK
8OS5
8R8D
1XR9
3BZH
4JJQ
5LBN
6FGA
8IYA
Enriched GO Terms of Interacting Partners
?
Ubiquitin Conjugating Enzyme Activity
Protein Metabolic Process
Proteolysis
Macromolecule Metabolic Process
Negative Regulation Of Blood Coagulation
Negative Regulation Of Hemostasis
Negative Regulation Of Coagulation
Collagen Metabolic Process
Negative Regulation Of Wound Healing
Regulation Of Hemostasis
Regulation Of Blood Coagulation
Fibrinolysis
Protein K48-linked Ubiquitination
Ubiquitin-protein Transferase Activity
Regulation Of Body Fluid Levels
Protein Polyubiquitination
Zymogen Activation
Regulation Of Wound Healing
Collagen Catabolic Process
Elastin Metabolic Process
Serine-type Endopeptidase Activity
Extracellular Matrix Disassembly
Regulation Of Response To Wounding
Hemopoiesis
Protein Monoubiquitination
Macromolecule Catabolic Process
Blood Coagulation, Intrinsic Pathway
Response To Amyloid-beta
Intracellular Oxygen Homeostasis
Plasminogen Activation
Regulation Of Post-translational Protein Modification
TOR Signaling
Extracellular Matrix Organization
Extracellular Structure Organization
Tissue Remodeling
Endopeptidase Activity
Negative Regulation Of TOR Signaling
Metalloendopeptidase Activity
Regulation Of Fibrinolysis
Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Polyubiquitination
Modification-dependent Protein Catabolic Process
Catabolic Process
Very-low-density Lipoprotein Particle
Protein Activation Cascade
Negative Regulation Of Signal Transduction
Regulation Of Protein Neddylation
Angiogenesis
Protein Maturation
Protein Ubiquitination
Ubiquitin Protein Ligase Activity
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Ubiquitin-protein Transferase Activity
Protein Modification Process
Protein Polyubiquitination
Transferase Activity
Protein Metabolic Process
Zinc Ion Binding
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Macromolecule Catabolic Process
Proteolysis
Metal Ion Binding
Macromolecule Metabolic Process
Protein Autoubiquitination
Catabolic Process
Protein K48-linked Ubiquitination
Protein K63-linked Ubiquitination
Proteasomal Protein Catabolic Process
Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Ubiquitin Ligase Complex
Cellular Response To Stress
Ubiquitin Protein Ligase Binding
Response To Stress
Regulation Of Post-translational Protein Modification
Cytoplasm
Positive Regulation Of Catabolic Process
Ubiquitin Binding
Positive Regulation Of Post-translational Protein Modification
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Autophagy
DNA Damage Response
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Ubiquitination
Protein K6-linked Ubiquitination
Negative Regulation Of Signal Transduction
Innate Immune Response
Regulation Of Signal Transduction
Immune System Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Regulation Of Protein Catabolic Process
Regulation Of Intracellular Signal Transduction
Regulation Of Signaling
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Tagcloud (Difference)
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Tagcloud (Intersection)
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