F12 and APOH

Number of citations of the paper that reports this interaction (PubMedID 3361230)
0

Data Source:
HPRD (in vitro)

		F12	APOH
Description		coagulation factor XII	apolipoprotein H
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Rough Endoplasmic Reticulum Plasma Membrane Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Space Cell Surface Platelet Dense Granule Lumen Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Misfolded Protein Binding	Protein Binding Phospholipid Binding Heparin Binding Lipid Binding Lipase Binding Identical Protein Binding Lipoprotein Lipase Activator Activity
	Biological Process	Plasma Kallikrein-kinin Cascade Factor XII Activation Proteolysis Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis Positive Regulation Of Plasminogen Activation Protein Processing Protein Autoprocessing Positive Regulation Of Blood Coagulation Zymogen Activation Fibrinolysis Innate Immune Response Response To Misfolded Protein Positive Regulation Of Fibrinolysis	Negative Regulation Of Endothelial Cell Proliferation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Regulation Of Blood Coagulation Positive Regulation Of Blood Coagulation Negative Regulation Of Blood Coagulation Plasminogen Activation Negative Regulation Of Myeloid Cell Apoptotic Process Triglyceride Transport Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling Negative Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Fibrinolysis Negative Regulation Of Fibrinolysis Positive Regulation Of Triglyceride Metabolic Process
Pathways		Intrinsic Pathway of Fibrin Clot Formation Defective factor XII causes hereditary angioedema Defective SERPING1 causes hereditary angioedema	Platelet degranulation
Drugs		Zinc Human C1-esterase inhibitor Ethanolamine oleate Conestat alfa Nafamostat Zinc acetate	LJP 1082 Copper
Diseases		Hereditary angioedema Factor XII deficiency; Hageman factor deficiency
GWAS		Activated partial thromboplastin time ( 22703881 20303064 29403010) Cardiac troponin-I levels ( 31014085) Chronic kidney disease ( 20383146) Circulating chromogranin peptide levels ( 28011710) Circulating vasoactive peptide levels ( 23381795) Glycine levels ( 30837465) L-arginine levels ( 27656708) Metabolite levels ( 22286219 22916037) Nephrolithiasis ( 22396660) Platelet function and related traits ( 21546496) Serum metabolite levels ( 33031748) Tinnitus ( 33742053) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	β2-Glycoprotein I (β2-GPI) plasma levels ( 23279374) Activated partial thromboplastin time ( 29403010) Alanine aminotransferase levels ( 34315874) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 34315874 33547301) Blood pressure measurement (high sodium and potassium intervention) ( 24165912) Brain morphology (MOSTest) ( 32665545) Cardiometabolic and hematological traits ( 27668658) Coronary artery disease ( 29212778) Creatine kinase levels ( 29403010) LDL cholesterol ( 24097068 30275531) LDL cholesterol levels ( 30698716 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipoprotein (a) levels ( 33730874) Liver enzyme levels (alanine transaminase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Presence of antiphospholipid antibodies ( 27098658) Systolic blood pressure ( 30224653) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 32203549 32154731) Triglycerides ( 30275531)
Interacting Genes		16 interacting genes: APOH APP CD93 EPAS1 GP1BA HIF1A KLKB1 KRT1 MMP12 MMP13 MMP14 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2N	14 interacting genes: AKT1 ANXA2 CDC42 CLEC4G F10 F12 GEM GRB2 LPA LRP2 LRP8 OGT PLG RBBP6
Entrez ID		2161	350
HPRD ID		01992	00728
Ensembl ID		ENSG00000131187	ENSG00000091583
Uniprot IDs		P00748 Q8IZZ5	A0A384NKM6 P02749
PDB IDs		4BDW 4BDX 4XDE 4XE4 6B74 6B77 6GT6 6L63 6QF7 6SZW 6X0S 6X0T 7FBP 7PRJ 7PRK 8OS5 8R8D	1C1Z 1G4F 1G4G 1QUB 2KRI 3OP8 4JHS 6V06 6V08 6V09 6XSD 6XST 7JIK 7KG4
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Metabolic Process Proteolysis Macromolecule Metabolic Process Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Collagen Metabolic Process Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Fibrinolysis Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Regulation Of Body Fluid Levels Protein Polyubiquitination Zymogen Activation Regulation Of Wound Healing Collagen Catabolic Process Elastin Metabolic Process Serine-type Endopeptidase Activity Extracellular Matrix Disassembly Regulation Of Response To Wounding Hemopoiesis Protein Monoubiquitination Macromolecule Catabolic Process Blood Coagulation, Intrinsic Pathway Response To Amyloid-beta Intracellular Oxygen Homeostasis Plasminogen Activation Regulation Of Post-translational Protein Modification TOR Signaling Extracellular Matrix Organization Extracellular Structure Organization Tissue Remodeling Endopeptidase Activity Negative Regulation Of TOR Signaling Metalloendopeptidase Activity Regulation Of Fibrinolysis Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Polyubiquitination Modification-dependent Protein Catabolic Process Catabolic Process Very-low-density Lipoprotein Particle Protein Activation Cascade Negative Regulation Of Signal Transduction Regulation Of Protein Neddylation Angiogenesis Protein Maturation Protein Ubiquitination	Fibrinolysis Apolipoprotein Binding Proteolysis Serine-type Peptidase Activity Positive Regulation Of Fibrinolysis Plasma Membrane Serine-type Endopeptidase Activity Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Positive Regulation Of Proteolysis Positive Regulation Of Multicellular Organismal Process Regulation Of Protein Maturation Positive Regulation Of Plasminogen Activation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Positive Regulation Of TOR Signaling Glutamatergic Synapse Regulation Of Body Fluid Levels Low-density Lipoprotein Particle Receptor Activity Regulation Of Cell Migration Regulation Of Synapse Organization Regulation Of Plasminogen Activation Calcium Ion Binding Coagulation Blood Coagulation Regulation Of Fibrinolysis Regulation Of Cell Motility Hemostasis Protein Maturation Regulation Of Locomotion Regulation Of Multicellular Organismal Process Labyrinthine Layer Blood Vessel Development External Side Of Plasma Membrane Regulation Of Proteolysis Regulation Of Postsynapse Organization Regulation Of Protein Catabolic Process Regulation Of Wound Healing Positive Regulation Of Protein Processing Positive Regulation Of Protein Maturation Spindle Midzone Positive Regulation Of Blood Coagulation Cargo Receptor Activity Blood Vessel Development Regulation Of TOR Signaling Positive Regulation Of Coagulation Embryonic Organ Development Placenta Blood Vessel Development Regulation Of Cell Adhesion
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