F12 and CD93

Number of citations of the paper that reports this interaction (PMID 8710908)
29

Data Source:
HPRD (in vitro)

		F12	CD93
Gene Name		coagulation factor XII (Hageman factor)	CD93 molecule
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Vesicular Exosome	Plasma Membrane Cell Surface Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Misfolded Protein Binding Serine-type Aminopeptidase Activity	Complement Component C1q Binding Receptor Activity Calcium Ion Binding Protein Binding Carbohydrate Binding
	Biological Process	Plasma Kallikrein-kinin Cascade Factor XII Activation Proteolysis Blood Coagulation Blood Coagulation, Intrinsic Pathway Positive Regulation Of Plasminogen Activation Protein Processing Protein Autoprocessing Positive Regulation Of Blood Coagulation Zymogen Activation Fibrinolysis Innate Immune Response Response To Misfolded Protein Positive Regulation Of Fibrinolysis	Phagocytosis Viral Process Single Organismal Cell-cell Adhesion Macrophage Activation
Pathways		Intrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881 20303064) Chronic kidney disease ( 20383146) Circulating vasoactive peptide levels ( 23381795) Metabolite levels ( 22286219 22916037) Nephrolithiasis ( 22396660) Platelet function and related traits ( 21546496)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		15 interactors: APOH APP CD93 EPAS1 GP1BA KLKB1 KRT1 MMP12 MMP13 MMP14 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2N	23 interactors: ARHGAP15 BAG6 C1QA COL1A1 COL1A2 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COPS5 F12 FAM46A GIPC1 KIR2DL2 KNG1 MBL2 MSN MYD88 RANBP1 SCYL1 UBQLN2
Entrez ID		2161	22918
HPRD ID		01992	00396
Ensembl ID		ENSG00000131187	ENSG00000125810
Uniprot IDs		P00748 Q8IZZ5	Q9NPY3
PDB IDs		4BDW 4BDX
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K48-linked Ubiquitination Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Protein Polyubiquitination Proteolysis Negative Regulation Of Wound Healing Blood Coagulation, Intrinsic Pathway Toll-like Receptor 4 Signaling Pathway Extracellular Matrix Disassembly Regulation Of Blood Coagulation Cellular Response To Hypoxia Protein Metabolic Process Cellular Response To Decreased Oxygen Levels Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Response To Hypoxia Fibrinolysis Regulation Of Wound Healing Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Extracellular Matrix Organization Extracellular Structure Organization Protein Activation Cascade Catabolic Process Positive Regulation Of Innate Immune Response Innate Immune Response Defense Response Collagen Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Plasminogen Activation Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Innate Immune Response Positive Regulation Of Ligase Activity Collagen Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Immune System Process Multicellular Organismal Macromolecule Metabolic Process Cellular Protein Catabolic Process Regulation Of Body Fluid Levels Protein Ubiquitination Multicellular Organismal Metabolic Process	Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Locomotion Movement Of Cell Or Subcellular Component Catabolic Process Protein Activation Cascade Axon Guidance Cellular Response To Amino Acid Stimulus Vesicle-mediated Transport Regulation Of Protein Processing Protein Heterotrimerization Axonogenesis Glomerular Basement Membrane Development Blood Coagulation, Intrinsic Pathway Regulation Of Blood Coagulation Response To External Stimulus Axon Development Response To Amino Acid Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Renal System Development Regulation Of Wound Healing Neuron Projection Morphogenesis Response To Stimulus Negative Regulation Of Proteolysis Endocytosis Receptor-mediated Endocytosis Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Protein Processing Establishment Of Endothelial Barrier Urogenital System Development Cell Morphogenesis Involved In Differentiation Immune System Process Protein Trimerization Cellular Response To Acid Chemical Blood Coagulation Inflammatory Response Hemostasis Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Platelet Activation Neuron Projection Development Cell Projection Morphogenesis
Tagcloud ?		amphotropic cem cemss clones deprived engineered episomal geneticin gp160 gp41 hut ltrs neo neomycin nonproducer packaging peculiar plj provirus retroviral retrovirus retroviruses sense ssti superinfecting superinfection syncytia therein uncleaved	29a 29b 29c acp5 calcitonin calcr cdc42 commitment concert cytoskeletal gpr85 gtpase hypothesize mir monocytic multinucleated nfia osteoclast osteoclastic osteoclasts raw264 rnas robo slit sponge srgap2 tartrate tempo transduced
Tagcloud (Difference) ?		amphotropic cem cemss clones deprived engineered episomal geneticin gp160 gp41 hut ltrs neo neomycin nonproducer packaging peculiar plj provirus retroviral retrovirus retroviruses sense ssti superinfecting superinfection syncytia therein uncleaved	29a 29b 29c acp5 calcitonin calcr cdc42 commitment concert cytoskeletal gpr85 gtpase hypothesize mir monocytic multinucleated nfia osteoclast osteoclastic osteoclasts raw264 rnas robo slit sponge srgap2 tartrate tempo transduced
Tagcloud (Intersection) ?