F12

Gene Name		coagulation factor XII (Hageman factor)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Misfolded Protein Binding Serine-type Aminopeptidase Activity
	Biological Process	Plasma Kallikrein-kinin Cascade Factor XII Activation Proteolysis Blood Coagulation Blood Coagulation, Intrinsic Pathway Positive Regulation Of Plasminogen Activation Protein Processing Protein Autoprocessing Positive Regulation Of Blood Coagulation Zymogen Activation Fibrinolysis Innate Immune Response Response To Misfolded Protein Positive Regulation Of Fibrinolysis
Pathways		Intrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881 20303064) Chronic kidney disease ( 20383146) Circulating vasoactive peptide levels ( 23381795) Metabolite levels ( 22286219 22916037) Nephrolithiasis ( 22396660) Platelet function and related traits ( 21546496)
Protein-protein Interactions		15 interactors: APOH APP CD93 EPAS1 GP1BA KLKB1 KRT1 MMP12 MMP13 MMP14 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2N
Entrez ID		2161
HPRD ID		01992
Ensembl ID		ENSG00000131187
Uniprot IDs		P00748 Q8IZZ5
PDB IDs		4BDW 4BDX
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K48-linked Ubiquitination Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Protein Polyubiquitination Proteolysis Negative Regulation Of Wound Healing Blood Coagulation, Intrinsic Pathway Toll-like Receptor 4 Signaling Pathway Extracellular Matrix Disassembly Regulation Of Blood Coagulation Cellular Response To Hypoxia Protein Metabolic Process Cellular Response To Decreased Oxygen Levels Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Response To Hypoxia Fibrinolysis Regulation Of Wound Healing Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Extracellular Matrix Organization Extracellular Structure Organization Protein Activation Cascade Catabolic Process Positive Regulation Of Innate Immune Response Innate Immune Response Defense Response Collagen Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Plasminogen Activation Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Innate Immune Response Positive Regulation Of Ligase Activity Collagen Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Immune System Process Multicellular Organismal Macromolecule Metabolic Process Cellular Protein Catabolic Process Regulation Of Body Fluid Levels Protein Ubiquitination Multicellular Organismal Metabolic Process
Tagcloud ?		amphotropic cem cemss clones deprived engineered episomal geneticin gp160 gp41 hut ltrs neo neomycin nonproducer packaging peculiar plj provirus retroviral retrovirus retroviruses sense ssti superinfecting superinfection syncytia therein uncleaved