F12

Description		coagulation factor XII
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Rough Endoplasmic Reticulum Plasma Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Misfolded Protein Binding
	Biological Process	Plasma Kallikrein-kinin Cascade Factor XII Activation Proteolysis Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis Positive Regulation Of Plasminogen Activation Protein Processing Protein Autoprocessing Positive Regulation Of Blood Coagulation Zymogen Activation Fibrinolysis Innate Immune Response Response To Misfolded Protein Positive Regulation Of Fibrinolysis
Pathways		Intrinsic Pathway of Fibrin Clot Formation Defective factor XII causes hereditary angioedema Defective SERPING1 causes hereditary angioedema
Drugs		Zinc Human C1-esterase inhibitor Ethanolamine oleate Conestat alfa Nafamostat Zinc acetate
Diseases		Hereditary angioedema Factor XII deficiency; Hageman factor deficiency
GWAS		Activated partial thromboplastin time ( 22703881 20303064 29403010) Cardiac troponin-I levels ( 31014085) Chronic kidney disease ( 20383146) Circulating chromogranin peptide levels ( 28011710) Circulating vasoactive peptide levels ( 23381795) Glycine levels ( 30837465) L-arginine levels ( 27656708) Metabolite levels ( 22286219 22916037) Nephrolithiasis ( 22396660) Platelet function and related traits ( 21546496) Serum metabolite levels ( 33031748) Tinnitus ( 33742053) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		16 interacting genes: APOH APP CD93 EPAS1 GP1BA HIF1A KLKB1 KRT1 MMP12 MMP13 MMP14 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2N
Entrez ID		2161
HPRD ID		01992
Ensembl ID		ENSG00000131187
Uniprot IDs		P00748 Q8IZZ5
PDB IDs		4BDW 4BDX 4XDE 4XE4 6B74 6B77 6GT6 6L63 6QF7 6SZW 6X0S 6X0T 7FBP 7PRJ 7PRK 8OS5 8R8D
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Metabolic Process Proteolysis Macromolecule Metabolic Process Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Collagen Metabolic Process Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Fibrinolysis Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Regulation Of Body Fluid Levels Protein Polyubiquitination Zymogen Activation Regulation Of Wound Healing Collagen Catabolic Process Elastin Metabolic Process Serine-type Endopeptidase Activity Extracellular Matrix Disassembly Regulation Of Response To Wounding Hemopoiesis Protein Monoubiquitination Macromolecule Catabolic Process Blood Coagulation, Intrinsic Pathway Response To Amyloid-beta Intracellular Oxygen Homeostasis Plasminogen Activation Regulation Of Post-translational Protein Modification TOR Signaling Extracellular Matrix Organization Extracellular Structure Organization Tissue Remodeling Endopeptidase Activity Negative Regulation Of TOR Signaling Metalloendopeptidase Activity Regulation Of Fibrinolysis Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Polyubiquitination Modification-dependent Protein Catabolic Process Catabolic Process Very-low-density Lipoprotein Particle Protein Activation Cascade Negative Regulation Of Signal Transduction Regulation Of Protein Neddylation Angiogenesis Protein Maturation Protein Ubiquitination
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