CDH5 and P2RX4

Number of citations of the paper that reports this interaction (PubMedID 12088286)
0

Data Source:
HPRD (in vivo)

		CDH5	P2RX4
Description		cadherin 5	purinergic receptor P2X 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction External Side Of Plasma Membrane Cell Surface Membrane Catenin Complex Cell Junction Nuclear Membrane Anchoring Junction Cell Periphery	Lysosome Lysosomal Membrane Plasma Membrane Membrane Cell Junction Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome Postsynapse
	Molecular Function	Signaling Receptor Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Protein Phosphatase Binding Signaling Receptor Complex Adaptor Activity Vascular Endothelial Growth Factor Receptor 2 Binding Transmembrane Transporter Binding Cadherin Binding Metal Ion Binding Fibrinogen Binding BMP Receptor Binding Cell-cell Adhesion Mediator Activity Protein Tyrosine Kinase Binding	Nucleotide Binding Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Monoatomic Cation Channel Activity Signaling Receptor Binding Monoatomic Ion Channel Activity Copper Ion Binding Protein Binding ATP Binding Zinc Ion Binding Identical Protein Binding Cadherin Binding Ligand-gated Calcium Channel Activity
	Biological Process	Cell Morphogenesis Endothelial Cell Morphogenesis Blood Vessel Maturation Cell Migration Involved In Sprouting Angiogenesis Intracellular Calcium Ion Homeostasis Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Microtubule Polymerization Positive Regulation Of Protein-containing Complex Assembly Adherens Junction Organization Maintenance Of Blood-brain Barrier Regulation Of Vascular Permeability Blood Vessel Endothelial Cell Migration Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Bicellular Tight Junction Assembly Cell-cell Adhesion Protein Localization To Bicellular Tight Junction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Establishment Of Endothelial Barrier Regulation Of Establishment Of Cell Polarity Negative Regulation Of Endothelial Cell Apoptotic Process	Tissue Homeostasis Regulation Of Sodium Ion Transport Response To Ischemia Monoatomic Ion Transport Response To Stress Signal Transduction Regulation Of Blood Pressure Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Metal Ion Transport Sensory Perception Of Pain Calcium-mediated Signaling Positive Regulation Of Cell Migration Positive Regulation Of Prostaglandin Secretion Response To ATP Monoatomic Ion Transmembrane Transport Response To Fluid Shear Stress Purinergic Nucleotide Receptor Signaling Pathway Endothelial Cell Activation Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Nitric Oxide Biosynthetic Process Behavioral Response To Pain Response To Axon Injury Positive Regulation Of Calcium-mediated Signaling Regulation Of Chemotaxis Sensory Perception Of Touch Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Membrane Depolarization Positive Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Relaxation Of Cardiac Muscle Excitatory Postsynaptic Potential Calcium Ion Transmembrane Transport Cellular Response To Zinc Ion Cellular Response To ATP Apoptotic Signaling Pathway Monoatomic Cation Transmembrane Transport Regulation Of Ruffle Assembly Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Microglial Cell Migration Positive Regulation Of Endothelial Cell Chemotaxis
Pathways		Adherens junctions interactions VEGFR2 mediated vascular permeability High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Elevation of cytosolic Ca2+ levels Platelet homeostasis Purinergic signaling in leishmaniasis infection
Drugs		Lenalidomide FX06	Promethazine Eslicarbazepine acetate Eslicarbazepine
Diseases
GWAS		Body size at age 10 ( 32376654) Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) High light scatter reticulocyte count ( 32888494) Iron status biomarkers (ferritin levels) ( 28334935) Lung function (FEV1/FVC) ( 30061609) Molar-incisor hypomineralization ( 23918034) Reticulocyte count ( 32888494)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Left ventricular obstructive tract defect (inherited effect) ( 28468790)
Interacting Genes		21 interacting genes: CSK CTNNA1 CTNNB1 CTNND1 DSP EGFR EPHA2 F2RL2 FGA JUP KDR P2RX4 P2RX6 PARD6A PKP4 PTPN11 PTPRB SHC1 SMG1 SRC VIM	9 interacting genes: CDH5 DNAAF6 KRTAP1-1 KRTAP12-3 KRTAP5-9 MCM2 NBPF19 NOTCH2NLA WNT4
Entrez ID		1003	5025
HPRD ID		03075	09017
Ensembl ID		ENSG00000179776	ENSG00000135124
Uniprot IDs		P33151 Q59EA3	Q99571
PDB IDs			9BQH 9BQI 9C48
Enriched GO Terms of Interacting Partners?		Cadherin Binding Cell Adhesion Anchoring Junction Cell Junction Catenin Complex Cell-cell Junction Organization Cell-cell Adhesion Cellular Response To Indole-3-methanol Response To Indole-3-methanol Regulation Of Protein Localization Adherens Junction Cell-cell Junction Plasma Membrane Cell Junction Organization Cell Migration Negative Regulation Of Multicellular Organismal Process Regulation Of ERK1 And ERK2 Cascade Focal Adhesion Positive Regulation Of Protein Localization Adherens Junction Organization Cell Motility Cell-cell Junction Assembly Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cellular Localization Desmosome ERBB Signaling Pathway Cell Junction Assembly Regulation Of Cell Adhesion Regulation Of Transport Flotillin Complex Cell Adhesion Molecule Binding Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of ERK1 And ERK2 Cascade Cell-cell Adhesion Mediated By Cadherin Response To Growth Factor Regulation Of MAPK Cascade Intercalated Disc Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Developmental Process Desmosome Organization Protein Tyrosine Kinase Activity Regulation Of Multicellular Organismal Process Shc-EGFR Complex Epithelial Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Protein Transport Cellular Response To Growth Factor Stimulus Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway	Intermediate Filament Mitotic DNA Replication Initiation Positive Regulation Of Translational Elongation Nuclear Division Positive Regulation Of Ribosome Biogenesis Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Renal Vesicle Induction Nephron Morphogenesis Positive Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Glucocorticoid Biosynthetic Process Positive Regulation Of Dermatome Development Negative Regulation Of Male Gonad Development Renal Vesicle Formation Somatotropin Secreting Cell Differentiation Female Sex Determination Paramesonephric Duct Development Positive Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Androgen Biosynthetic Process Metanephric Nephron Morphogenesis Negative Regulation Of Testicular Blood Vessel Morphogenesis Negative Regulation Of Testosterone Biosynthetic Process Metanephric Nephron Development Keratin Filament Positive Regulation Of Establishment Of Endothelial Barrier Protein Localization To Bicellular Tight Junction Positive Regulation Of Cellular Component Biogenesis Regulation Of Ribosome Biogenesis Mitotic Nuclear Division Histone H2A Deubiquitinase Activity Metanephric Tubule Formation Metanephric Mesenchymal Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Positive Regulation Of Steroid Hormone Biosynthetic Process Pericyte Cell Differentiation Immature T Cell Proliferation In Thymus Blood Vessel Maturation Fibrinogen Binding Regulation Of Cortisol Biosynthetic Process Mesenchymal Cell Differentiation Involved In Kidney Development Regulation Of Testosterone Biosynthetic Process Histone Binding
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