CDH5 and PKP4

Number of citations of the paper that reports this interaction (PMID 12426320)
15

Data Source:
HPRD (two hybrid, in vitro)

		CDH5	PKP4
Gene Name		cadherin 5, type 2 (vascular endothelium)	plakophilin 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Adherens Junction Tight Junction Membrane Integral Component Of Membrane Cell Junction	Spindle Pole Cytoplasm Cytoskeleton Plasma Membrane Cell-cell Junction Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Desmosome Midbody Cell-cell Contact Zone Perinuclear Region Of Cytoplasm Spindle Midzone Mitotic Spindle
	Molecular Function	Receptor Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Protein Phosphatase Binding Ion Channel Binding	Protein Binding
	Biological Process	Blood Vessel Maturation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Proliferation Cell Junction Assembly Adherens Junction Organization Cell-cell Junction Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Establishment Of Cell Polarity	Cell-cell Junction Assembly Cell-cell Signaling Single Organismal Cell-cell Adhesion Regulation Of Cell Adhesion Positive Regulation Of Rho GTPase Activity Positive Regulation Of Cytokinesis
Pathways		Cell junction organization Cell-cell junction organization Signaling by VEGF Adherens junctions interactions VEGFR2 mediated vascular permeability VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		20 interactors: CSK CTNNA1 CTNNB1 CTNND1 DSP EPHA2 F2RL2 FGA JUP KDR P2RX4 P2RX6 PARD6A PKP4 PTPN11 PTPRB SHC1 SMG1 SRC VIM	18 interactors: ATPAF2 CDH1 CDH2 CDH5 DSC3 DSP ERBB2IP GABARAP GOLGA2 LNX1 LZTS2 MINK1 OSGEP PAXIP1 PDZD2 PGAM1 PSEN1 TRIM23
Entrez ID		1003	8502
HPRD ID		03075	05043
Ensembl ID		ENSG00000179776	ENSG00000144283
Uniprot IDs		P33151	Q99569
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell-cell Junction Organization Adherens Junction Organization Signaling Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Single Organismal Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organonitrogen Compound Signal Transduction Cellular Response To Indole-3-methanol Cell Junction Assembly Regulation Of ERK1 And ERK2 Cascade Cell Adhesion Cellular Response To Stimulus Positive Regulation Of Signal Transduction Regulation Of MAPK Cascade Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Adhesion Response To Stimulus Regulation Of Signal Transduction Response To Wounding Positive Regulation Of MAPK Cascade Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Response To Organonitrogen Compound Cell Migration Cell Motility Wound Healing Response To Growth Factor Regulation Of Intracellular Signal Transduction Platelet Activation Organ Development Cellular Response To Organic Substance Cellular Component Assembly Cell Activation Blood Coagulation Regulation Of Cellular Localization Hemostasis Response To Organic Substance Movement Of Cell Or Subcellular Component Cell-cell Junction Assembly Protein Heterooligomerization Negative Regulation Of Signaling Regulation Of Protein Localization System Development Peptidyl-tyrosine Phosphorylation Response To Stress Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Phosphorylation	Cell Adhesion Adherens Junction Organization Single Organismal Cell-cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Bundle Of His Cell To Purkinje Myocyte Communication Cell-cell Junction Organization Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Cellular Component Assembly Ventricular Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Cellular Response To Starvation Negative Regulation Of Canonical Wnt Signaling Pathway Cardiac Muscle Cell Action Potential Involved In Contraction Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cellular Response To Nutrient Levels Response To Starvation Cardiovascular System Development Cardiac Muscle Cell Action Potential Negative Regulation Of Wnt Signaling Pathway Autophagic Vacuole Assembly Cell Junction Assembly Regulation Of Protein Ubiquitination Intermediate Filament Cytoskeleton Organization Blood Vessel Development Intermediate Filament-based Process Cellular Response To Extracellular Stimulus Regulation Of Cardiac Muscle Cell Contraction Vasculature Development Cardiac Conduction Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Stress Macroautophagy Cajal-Retzius Cell Differentiation Positive Regulation Of Histone H3-K36 Methylation Regulation Of Pentose-phosphate Shunt Beta-amyloid Formation Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Membrane Potential Organelle Organization Cytoskeleton Organization Regulation Of Wnt Signaling Pathway Execution Phase Of Apoptosis Regulation Of Heart Rate Regulation Of Cellular Component Movement Regulation Of Cardiac Muscle Contraction Threonylcarbamoyladenosine Biosynthetic Process Basal Protein Localization
Tagcloud ?		1beta bioreactor cd11b constructs dataset dioxepan dxo ec ecs engineered hif immunodeficient immunofluorescent implanted lactide leukocyte leukocytes lla migrating msc mscs multipotent pecam retrieved scaffolds subcutaneously toll transmigration umbilical
Tagcloud (Difference) ?		1beta bioreactor cd11b constructs dataset dioxepan dxo ec ecs engineered hif immunodeficient immunofluorescent implanted lactide leukocyte leukocytes lla migrating msc mscs multipotent pecam retrieved scaffolds subcutaneously toll transmigration umbilical
Tagcloud (Intersection) ?