F2RL1 and RAD17

		F2RL1	RAD17
Description		F2R like trypsin receptor 1	RAD17 checkpoint clamp loader component
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GO Annotations	Cellular Component	Early Endosome Golgi Apparatus Plasma Membrane Membrane Pseudopodium	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Nucleolus Rad17 RFC-like Complex Site Of Double-strand Break
	Molecular Function	Proteinase-activated Receptor Activity G-protein Alpha-subunit Binding Protease Binding G Protein-coupled Receptor Activity Signaling Receptor Binding Protein Binding Thrombin-activated Receptor Activity G-protein Beta-subunit Binding Signaling Receptor Activity	Nucleotide Binding Chromatin Binding DNA Clamp Loader Activity Protein Binding ATP Binding Chromatin-protein Adaptor Activity
	Biological Process	T Cell Activation Involved In Immune Response Immune System Process Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Glomerular Filtration Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Pseudopodium Assembly Negative Regulation Of Chemokine Production Positive Regulation Of Chemokine Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Rho Protein Signal Transduction Neutrophil Activation Vasodilation Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Eosinophil Degranulation Positive Regulation Of GTPase Activity Innate Immune Response Cell-cell Junction Maintenance Positive Regulation Of Transcription By RNA Polymerase II Regulation Of JNK Cascade Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Negative Regulation Of Insulin Secretion Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Positive Chemotaxis Defense Response To Virus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phagocytosis, Engulfment Establishment Of Endothelial Barrier Regulation Of Biological Quality Positive Regulation Of ERK1 And ERK2 Cascade Thrombin-activated Receptor Signaling Pathway Leukocyte Proliferation Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Mature Conventional Dendritic Cell Differentiation Positive Regulation Of Renin Secretion Into Blood Stream Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair Chromatin Organization DNA Damage Response Negative Regulation Of DNA Replication Mitotic Intra-S DNA Damage Checkpoint Signaling Mitotic DNA Replication Checkpoint Signaling Regulation Of Phosphorylation Protein Localization To Site Of Double-strand Break
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Serum bilirubin levels x sex interaction in metabolic syndrome ( 30621171)	Blood urea nitrogen levels ( 31152163)
Interacting Genes		76 interacting genes: ABCC8 ABHD14A ADCY2 ARL6IP1 ATP2A2 ATP2B1 ATP2C1 BSG CANX CAPN1 CAPN2 CAPNS1 CBL CD63 CD81 CLPTM1 CNN3 COPS5 CRLS1 CTNNA1 CTSG DNMT3L ELANE ERGIC3 F2 GJB6 GJC2 GPRASP1 HERPUD1 HLA-E HMOX2 HSPA1B ICAM2 KDELR1 KLC1 LMNA MORN4 NAT14 NBPF15 OSTC P4HTM PHLDA1 PIGU PLG PPM1J PRNP PRRT2 PRTN3 PSMC3 PTDSS2 QSER1 R3HDM1 RGR RTN1 RTN4 SCN1B SDHD SLC12A5 SLC18B1 SLC1A4 SLC31A2 SLC32A1 SLC35A1 SLC39A13 SLC43A2 SLC75A1 ST14 SYNGR2 TMBIM1 TMED1 TMEM161A TMEM62 TMX2 WFS1 YIPF1 YIPF6	20 interacting genes: ATM ATR CLSPN CSNK1E CSNK2A1 CSNK2B HUS1 MCM7 POLE PRKDC PRMT6 RAD1 RAD9A RAD9B RFC2 RFC3 RFC4 SMG7 SNU13 USP20
Entrez ID		2150	5884
HPRD ID		02960	09124
Ensembl ID		ENSG00000164251	ENSG00000152942
Uniprot IDs		P55085	A0A0G2JP78 O75943
PDB IDs		5NDD 5NDZ 5NJ6	7Z6H 8GNN
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Cellular Homeostasis Intracellular Chemical Homeostasis Endoplasmic Reticulum Calpain Complex Endoplasmic Reticulum Tubular Network Formation Endoplasmic Reticulum Membrane Intracellular Monoatomic Cation Homeostasis Synaptic Vesicle Membrane Intracellular Monoatomic Ion Homeostasis Regulation Of Transport Inorganic Ion Homeostasis Endoplasmic Reticulum Tubular Network Membrane Organization Transmembrane Transport P-type Calcium Transporter Activity Calcium-dependent Cysteine-type Endopeptidase Activity Neutrophil-mediated Killing Of Bacterium Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Inorganic Ion Transmembrane Transport Biological Process Involved In Interaction With Symbiont Serine-type Peptidase Activity Intracellular Calcium Ion Homeostasis Inorganic Cation Transmembrane Transport Positive Regulation Of Transport Monoatomic Cation Transmembrane Transport Regulation Of Metal Ion Transport Cytoplasmic Vesicle Endoplasmic Reticulum Membrane Organization Regulation Of Postsynapse Assembly Monoatomic Ion Transmembrane Transport Chemical Homeostasis Dendrite Calcium Ion Homeostasis Serine-type Endopeptidase Activity Acidic Amino Acid Transport Endoplasmic Reticulum Tubular Network Organization Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling Negative Regulation Of Apoptotic Signaling Pathway Neutrophil Mediated Immunity Regulation Of Monoatomic Ion Transport Golgi Apparatus Endoplasmic Reticulum Calcium Ion Homeostasis Neutrophil-mediated Killing Of Gram-negative Bacterium Negative Regulation Of Amyloid-beta Formation Monoatomic Cation Transport Positive Regulation Of Blood Coagulation Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Protein Localization	DNA Repair DNA Metabolic Process DNA Damage Response DNA Damage Checkpoint Signaling Nucleic Acid Metabolic Process Signal Transduction In Response To DNA Damage Cellular Response To Stress Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Checkpoint Clamp Complex Negative Regulation Of Cell Cycle Process Response To Stress Negative Regulation Of Cell Cycle Macromolecule Metabolic Process Mitotic DNA Damage Checkpoint Signaling Cellular Response To Ionizing Radiation Mitotic DNA Integrity Checkpoint Signaling Response To Ionizing Radiation Regulation Of Cell Cycle Phase Transition Histone H2AXS139 Kinase Activity DNA Strand Elongation Involved In DNA Replication Nucleoplasm Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Single-stranded DNA Helicase Activity DNA Replication Checkpoint Signaling DNA Strand Elongation DNA Replication Factor C Complex DNA Replication Cellular Response To Radiation Regulation Of DNA Biosynthetic Process Ctf18 RFC-like Complex Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Process DNA Clamp Loader Activity Positive Regulation Of DNA-directed DNA Polymerase Activity Double-strand Break Repair DNA-templated DNA Replication Mitotic G2/M Transition Checkpoint Double-strand Break Repair Via Homologous Recombination Nucleus Response To Radiation Recombinational Repair Positive Regulation Of DNA Metabolic Process Mitotic Intra-S DNA Damage Checkpoint Signaling Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Telomerase Catalytic Core Complex Assembly Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
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