F2RL1 and F2R

		F2RL1	F2R
Description		F2R like trypsin receptor 1	coagulation factor II thrombin receptor
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GO Annotations	Cellular Component	Early Endosome Golgi Apparatus Plasma Membrane Membrane Pseudopodium	Extracellular Region Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Caveola Cell Surface Membrane Platelet Dense Tubular Network Neuromuscular Junction Postsynaptic Membrane
	Molecular Function	Proteinase-activated Receptor Activity G-protein Alpha-subunit Binding Protease Binding G Protein-coupled Receptor Activity Signaling Receptor Binding Protein Binding Thrombin-activated Receptor Activity G-protein Beta-subunit Binding Signaling Receptor Activity	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Signaling Receptor Binding Protein Binding Thrombin-activated Receptor Activity G-protein Beta-subunit Binding
	Biological Process	T Cell Activation Involved In Immune Response Immune System Process Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Glomerular Filtration Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Pseudopodium Assembly Negative Regulation Of Chemokine Production Positive Regulation Of Chemokine Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Rho Protein Signal Transduction Neutrophil Activation Vasodilation Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Eosinophil Degranulation Positive Regulation Of GTPase Activity Innate Immune Response Cell-cell Junction Maintenance Positive Regulation Of Transcription By RNA Polymerase II Regulation Of JNK Cascade Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Negative Regulation Of Insulin Secretion Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Positive Chemotaxis Defense Response To Virus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phagocytosis, Engulfment Establishment Of Endothelial Barrier Regulation Of Biological Quality Positive Regulation Of ERK1 And ERK2 Cascade Thrombin-activated Receptor Signaling Pathway Leukocyte Proliferation Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Mature Conventional Dendritic Cell Differentiation Positive Regulation Of Renin Secretion Into Blood Stream Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Negative Regulation Of Glomerular Filtration Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Establishment Of Synaptic Specificity At Neuromuscular Junction Blood Coagulation Hemostasis Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Wounding Anatomical Structure Morphogenesis Glutamate Secretion Platelet Activation Regulation Of Blood Coagulation Positive Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Response To Lipopolysaccharide Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Rho Protein Signal Transduction Dendritic Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Cell-cell Junction Maintenance Positive Regulation Of DNA-templated Transcription Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Synaptic Plasticity Homeostasis Of Number Of Cells Within A Tissue Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Calcium Ion Transport Platelet Dense Granule Organization Regulation Of Biological Quality Positive Regulation Of ERK1 And ERK2 Cascade Thrombin-activated Receptor Signaling Pathway Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission Negative Regulation Of Renin Secretion Into Blood Stream
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Common Pathway of Fibrin Clot Formation Peptide ligand-binding receptors G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs)
Drugs			Streptokinase SR-123781A Vorapaxar Thrombin
Diseases
GWAS		Serum bilirubin levels x sex interaction in metabolic syndrome ( 30621171)	Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Mean platelet volume ( 22139419) Platelet count ( 22139419) Platelet distribution width ( 27863252)
Interacting Genes		76 interacting genes: ABCC8 ABHD14A ADCY2 ARL6IP1 ATP2A2 ATP2B1 ATP2C1 BSG CANX CAPN1 CAPN2 CAPNS1 CBL CD63 CD81 CLPTM1 CNN3 COPS5 CRLS1 CTNNA1 CTSG DNMT3L ELANE ERGIC3 F2 GJB6 GJC2 GPRASP1 HERPUD1 HLA-E HMOX2 HSPA1B ICAM2 KDELR1 KLC1 LMNA MORN4 NAT14 NBPF15 OSTC P4HTM PHLDA1 PIGU PLG PPM1J PRNP PRRT2 PRTN3 PSMC3 PTDSS2 QSER1 R3HDM1 RGR RTN1 RTN4 SCN1B SDHD SLC12A5 SLC18B1 SLC1A4 SLC31A2 SLC32A1 SLC35A1 SLC39A13 SLC43A2 SLC75A1 ST14 SYNGR2 TMBIM1 TMED1 TMEM161A TMEM62 TMX2 WFS1 YIPF1 YIPF6	19 interacting genes: ATP13A2 CAPN1 CHRD CTSG CXCL14 ELANE F2 GNA12 GNA13 GNA15 GNAI2 GNAT1 GPRASP1 ITGAV PDCD6IP PLG PRTN3 SNCA SNX1
Entrez ID		2150	2149
HPRD ID		02960	01763
Ensembl ID		ENSG00000164251	ENSG00000181104
Uniprot IDs		P55085	P25116
PDB IDs		5NDD 5NDZ 5NJ6	1NRN 1NRO 1NRP 1NRQ 1NRR 3BEF 3HKI 3HKJ 3LU9 3VW7 8XOR 8XOS
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Cellular Homeostasis Intracellular Chemical Homeostasis Endoplasmic Reticulum Calpain Complex Endoplasmic Reticulum Tubular Network Formation Endoplasmic Reticulum Membrane Intracellular Monoatomic Cation Homeostasis Synaptic Vesicle Membrane Intracellular Monoatomic Ion Homeostasis Regulation Of Transport Inorganic Ion Homeostasis Endoplasmic Reticulum Tubular Network Membrane Organization Transmembrane Transport P-type Calcium Transporter Activity Calcium-dependent Cysteine-type Endopeptidase Activity Neutrophil-mediated Killing Of Bacterium Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Inorganic Ion Transmembrane Transport Biological Process Involved In Interaction With Symbiont Serine-type Peptidase Activity Intracellular Calcium Ion Homeostasis Inorganic Cation Transmembrane Transport Positive Regulation Of Transport Monoatomic Cation Transmembrane Transport Regulation Of Metal Ion Transport Cytoplasmic Vesicle Endoplasmic Reticulum Membrane Organization Regulation Of Postsynapse Assembly Monoatomic Ion Transmembrane Transport Chemical Homeostasis Dendrite Calcium Ion Homeostasis Serine-type Endopeptidase Activity Acidic Amino Acid Transport Endoplasmic Reticulum Tubular Network Organization Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling Negative Regulation Of Apoptotic Signaling Pathway Neutrophil Mediated Immunity Regulation Of Monoatomic Ion Transport Golgi Apparatus Endoplasmic Reticulum Calcium Ion Homeostasis Neutrophil-mediated Killing Of Gram-negative Bacterium Negative Regulation Of Amyloid-beta Formation Monoatomic Cation Transport Positive Regulation Of Blood Coagulation Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Protein Localization	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Binding Biological Process Involved In Interaction With Symbiont Neutrophil-mediated Killing Of Bacterium Serine-type Peptidase Activity Serine-type Endopeptidase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Locomotion D5 Dopamine Receptor Binding Extracellular Exosome Biogenesis Regulation Of Vesicle-mediated Transport Neutrophil Mediated Immunity Regulation Of Exocytosis Positive Regulation Of Exocytosis Leukocyte Migration Killing By Host Of Symbiont Cells Coagulation Blood Coagulation Regulation Of Cell Migration Protease Binding Hemostasis Extracellular Vesicle Biogenesis Peptidase Activity Regulation Of Cell Motility Killing Of Cells Of Another Organism Neutrophil-mediated Killing Of Gram-negative Bacterium Mature Conventional Dendritic Cell Differentiation Regulation Of Body Fluid Levels Regulation Of Reactive Oxygen Species Metabolic Process G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Secretion By Cell Rho-activating G Protein-coupled Receptor Signaling Pathway Extracellular Matrix Disassembly Positive Regulation Of Secretion GTPase Activity Regulation Of Catalytic Activity Antimicrobial Humoral Response Extracellular Exosome Regulation Of Secretion By Cell Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Chaperone-mediated Autophagy Extracellular Region Regulation Of Biological Quality Regulation Of Cell Population Proliferation Cell Migration GTP Binding Positive Regulation Of Cell Population Proliferation
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