SDHD and GPR35

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		SDHD	GPR35
Description		succinate dehydrogenase complex subunit D	G protein-coupled receptor 35
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Envelope Mitochondrial Inner Membrane Membrane Respiratory Chain Complex II (succinate Dehydrogenase)	Plasma Membrane Membrane
	Molecular Function	Protein Binding Succinate Dehydrogenase (quinone) Activity Electron Transfer Activity Heme Binding Metal Ion Binding Ubiquinone Binding	G Protein-coupled Receptor Activity Chemokine Receptor Activity C-X-C Chemokine Receptor Activity
	Biological Process	Tricarboxylic Acid Cycle Mitochondrial Electron Transport, Succinate To Ubiquinone Proton Motive Force-driven Mitochondrial ATP Synthesis Regulation Of Catecholamine Secretion Cellular Response To Hypoxia	Cytoskeleton Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Chemokine-mediated Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity
Pathways		Respiratory electron transport Citric acid cycle (TCA cycle) Maturation of TCA enzymes and regulation of TCA cycle	Class A/1 (Rhodopsin-like receptors)
Drugs		Hexachlorophene 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Ubiquinone Q1	Furosemide Pyrantel Kynurenic Acid
Diseases		Carcinoid
GWAS		Brain morphology (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Waist circumference adjusted for body mass index ( 34021172)	Ankylosing spondylitis ( 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 25489960) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 23128233 28067908) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Pediatric autoimmune diseases ( 26301688) Sclerosing cholangitis and ulcerative colitis (combined) ( 22821403) Ulcerative colitis ( 21297633 28067908)
Interacting Genes		5 interacting genes: F2RL1 GPR35 MTNR1B RHBDD2 SLC13A1	58 interacting genes: ABHD14A ADGRB1 AIG1 APH1A ATP1A1 ATP2C1 B3GAT3 B4GALT2 BNIP1 CANX CD81 CH25H CMTM3 CRHR2 ERGIC3 FLRT1 FTH1 GHITM GJC2 GPR146 GPR161 HLA-A KCNJ4 KDELR1 LSS MCOLN1 MSMO1 NPC1 NSDHL OSTC PLD3 PLLP PLXDC1 PPP1R3F RTN3 RTN4 SCARB1 SDHD SELENOK SLC15A4 SLC2A1 SLC31A2 SLC37A1 SLC37A4 SLC45A4 SLC8A2 SLC9A7 SPART SYNGR2 SYT11 TMEM161A TMEM94 TSPAN7 VPS25 VTI1B YIF1B ZDHHC3 ZFAND1
Entrez ID		6392	2859
HPRD ID		04069	16003
Ensembl ID		ENSG00000204370	ENSG00000178623
Uniprot IDs		A0A0S2Z4H7 A0A0S2Z4J3 O14521	A8K2J1 B2RA17 Q9HC97
PDB IDs		8GS8	8H8J
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion G Protein-coupled Receptor Activity Negative Regulation Of Protein Secretion Negative Regulation Of Hormone Secretion Negative Regulation Of Transport Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Proteinase-activated Receptor Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance Negative Regulation Of Secretion By Cell Positive Regulation Of Glomerular Filtration G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Protein Transport Regulation Of Renin Secretion Into Blood Stream Regulation Of Tube Size Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Establishment Of Protein Localization Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Sodium:sulfate Symporter Activity Monoatomic Anion:sodium Symporter Activity Regulation Of Insulin Secretion Negative Regulation Of Secretion Positive Regulation Of Killing Of Cells Of Another Organism Melatonin Receptor Activity Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Peptide Hormone Secretion Mature Conventional Dendritic Cell Differentiation Thrombin-activated Receptor Activity Regulation Of Neuronal Action Potential Negative Regulation Of Protein Localization Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Cytotoxicity Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Hormone Secretion Regulation Of Protein Secretion Vascular Process In Circulatory System C-X-C Chemokine Receptor Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Secondary Active Sulfate Transmembrane Transporter Activity Signal Recognition Particle Binding Regulation Of Glomerular Filtration Thrombin-activated Receptor Signaling Pathway	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Golgi Apparatus Golgi Membrane Inorganic Ion Transmembrane Transport Transmembrane Transport Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Monoatomic Cation Transport Monoatomic Ion Transport Membrane Organization Cholesterol Metabolic Process Metal Ion Transport Sterol Metabolic Process Inorganic Cation Transmembrane Transport Regulation Of Toll-like Receptor 9 Signaling Pathway Monoatomic Cation Transmembrane Transport Import Across Plasma Membrane Sterol Biosynthetic Process Positive Regulation Of Protein Localization Endoplasmic Reticulum Membrane Organization Chemical Homeostasis Cytoplasmic Vesicle Membrane Plasma Membrane Lysosome Glucose 6-phosphate:phosphate Antiporter Activity C-4 Methylsterol Oxidase Activity Lysosomal Membrane Import Into Cell Monoatomic Ion Transmembrane Transport Intracellular Monoatomic Cation Homeostasis Intracellular Chemical Homeostasis Intracellular Monoatomic Ion Homeostasis Vesicle-mediated Transport Recycling Endosome Glucose-6-phosphate Transport Phagocytic Cup Carbohydrate Derivative Transport Steroid Metabolic Process Potassium Ion Transmembrane Transport Endoplasmic Reticulum Tubular Network Formation Late Endosome Membrane Monoatomic Cation Homeostasis Regulation Of Protein Localization Steroid Biosynthetic Process Monoatomic Ion Homeostasis Postsynaptic Density Proton Transmembrane Transport Cholesterol Biosynthetic Process Positive Regulation Of Intracellular Protein Transport
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