F2R and PRTN3

Number of citations: 0 (PubMedID 10978167)
Data Source: HPRD (in vitro)

		F2R	PRTN3
Name		coagulation factor II thrombin receptor	proteinase 3
Structure
GO Annotations	Cellular Component	Extracellular Region Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Caveola Cell Surface Membrane Platelet Dense Tubular Network Neuromuscular Junction Postsynaptic Membrane	Extracellular Region Extracellular Space Cytosol Plasma Membrane Membrane Extracellular Matrix Azurophil Granule Lumen Plasma Membrane Raft Membrane Raft Extracellular Exosome
	Molecular Function	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Signaling Receptor Binding Protein Binding Thrombin-activated Receptor Activity G-protein Beta-subunit Binding	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Enzyme Binding
	Biological Process	Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Negative Regulation Of Glomerular Filtration Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Establishment Of Synaptic Specificity At Neuromuscular Junction Blood Coagulation Hemostasis Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Wounding Anatomical Structure Morphogenesis Glutamate Secretion Platelet Activation Regulation Of Blood Coagulation Positive Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Response To Lipopolysaccharide Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Rho Protein Signal Transduction Dendritic Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Cell-cell Junction Maintenance Positive Regulation Of DNA-templated Transcription Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Synaptic Plasticity Homeostasis Of Number Of Cells Within A Tissue Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Calcium Ion Transport Platelet Dense Granule Organization Regulation Of Biological Quality Positive Regulation Of ERK1 And ERK2 Cascade Thrombin-activated Receptor Signaling Pathway Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission Negative Regulation Of Renin Secretion Into Blood Stream	Proteolysis Membrane Protein Ectodomain Proteolysis Positive Regulation Of Cell Population Proliferation Antimicrobial Humoral Response Collagen Catabolic Process Positive Regulation Of GTPase Activity Cell-cell Junction Maintenance Negative Regulation Of Phagocytosis Neutrophil Extravasation Mature Conventional Dendritic Cell Differentiation
Pathways		Common Pathway of Fibrin Clot Formation Peptide ligand-binding receptors G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs)	Common Pathway of Fibrin Clot Formation Other interleukin signaling Neutrophil degranulation Antimicrobial peptides
Drugs		Streptokinase SR-123781A Vorapaxar Thrombin	Elafin
GWAS		Dental caries (decayed, missing and filled tooth surfaces) ( 31533690 ) Erosive tooth wear (severe vs non-severe) ( 29898447 ) Erosive tooth wear (severe vs none or mild) ( 29898447 ) Mean platelet volume ( 22139419 ) Platelet count ( 22139419 ) Platelet distribution width ( 27863252 )	Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757 ) Basophil count ( 32888494 ) Basophil percentage of granulocytes ( 27863252 ) Basophil percentage of white cells ( 27863252 32888494 ) Blood protein levels ( 30072576 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 27863252 32888494 ) White blood cell count (basophil) ( 27863252 )
Interacting Genes		19 interacting genes: ATP13A2 CAPN1 CHRD CTSG CXCL14 ELANE F2 GNA12 GNA13 GNA15 GNAI2 GNAT1 GPRASP1 ITGAV PDCD6IP PLG PRTN3 SNCA SNX1	13 interacting genes: CAMP ELN F2R F2RL1 IL1B IL32 ITGB2 RELA SERPINA1 SERPINB1 SERPINB13 SMAD3 TNF
Entrez ID		2149	5657
HPRD ID		01763	01512
Ensembl ID		ENSG00000181104	ENSG00000196415
Uniprot IDs		P25116	P24158
PDB IDs		1NRN 1NRO 1NRP 1NRQ 1NRR 3BEF 3HKI 3HKJ 3LU9 3VW7 8XOR 8XOS	1FUJ
GO Terms Enriched among Interactors		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Binding Biological Process Involved In Interaction With Symbiont Neutrophil-mediated Killing Of Bacterium Serine-type Peptidase Activity Serine-type Endopeptidase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Locomotion D5 Dopamine Receptor Binding Extracellular Exosome Biogenesis Regulation Of Vesicle-mediated Transport Neutrophil Mediated Immunity Regulation Of Exocytosis Positive Regulation Of Exocytosis Leukocyte Migration Killing By Host Of Symbiont Cells Coagulation Blood Coagulation Regulation Of Cell Migration Protease Binding Hemostasis Extracellular Vesicle Biogenesis Peptidase Activity Regulation Of Cell Motility Killing Of Cells Of Another Organism Neutrophil-mediated Killing Of Gram-negative Bacterium Mature Conventional Dendritic Cell Differentiation Regulation Of Body Fluid Levels Regulation Of Reactive Oxygen Species Metabolic Process G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Secretion By Cell Rho-activating G Protein-coupled Receptor Signaling Pathway Extracellular Matrix Disassembly Positive Regulation Of Secretion GTPase Activity Regulation Of Catalytic Activity Antimicrobial Humoral Response Extracellular Exosome Regulation Of Secretion By Cell Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Chaperone-mediated Autophagy Extracellular Region Regulation Of Biological Quality Regulation Of Cell Population Proliferation Cell Migration GTP Binding Positive Regulation Of Cell Population Proliferation	Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-8 Production Regulation Of Interleukin-8 Production Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Positive Regulation Of Interleukin-1 Beta Production Inflammatory Response Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Establishment Of Protein Localization Defense Response Positive Regulation Of Establishment Of Protein Localization Regulation Of Interleukin-6 Production Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Cell Activation Positive Regulation Of Chemokine Production Positive Regulation Of Multicellular Organismal Process Regulation Of Protein Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Humoral Immune Response Positive Regulation Of Gene Expression Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Chemokine Production Positive Regulation Of Protein Transport Positive Regulation Of Transport Regulation Of Protein Secretion Immune System Process Negative Regulation Of Apoptotic Process Protease Binding Negative Regulation Of MiRNA Transcription Negative Regulation Of Programmed Cell Death Regulation Of Protein Localization Regulation Of Renin Secretion Into Blood Stream Regulation Of Secretion By Cell Regulation Of Immune Response Response To Lipopolysaccharide Myeloid Leukocyte Activation Regulation Of Programmed Cell Death Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Angiogenesis Regulation Of Wound Healing Regulation Of Vasculature Development Response To Molecule Of Bacterial Origin Regulation Of Secretion Regulation Of Protein Metabolic Process