F2R and GNAT1

Number of citations of the paper that reports this interaction (PMID 10583385)
1

Data Source:
HPRD (in vitro)

		F2R	GNAT1
Gene Name		coagulation factor II (thrombin) receptor	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Early Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Caveola Platelet Dense Tubular Network Neuromuscular Junction Postsynaptic Membrane	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Apical Plasma Membrane Photoreceptor Connecting Cilium Photoreceptor Outer Segment Membrane Neuronal Cell Body Photoreceptor Disc Membrane
	Molecular Function	G-protein Alpha-subunit Binding G-protein Coupled Receptor Activity Receptor Binding Protein Binding Thrombin Receptor Activity G-protein Beta-subunit Binding	Acyl Binding G-protein Coupled Receptor Binding GTPase Activity Signal Transducer Activity GTP Binding GDP Binding Protein Kinase Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Activation Of MAPKK Activity Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Negative Regulation Of Glomerular Filtration Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Tyrosine Phosphorylation Of STAT Protein STAT Protein Import Into Nucleus Establishment Of Synaptic Specificity At Neuromuscular Junction Blood Coagulation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Wounding Anatomical Structure Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Platelet Activation Regulation Of Blood Coagulation Positive Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Response To Lipopolysaccharide Regulation Of Interleukin-1 Beta Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of JAK-STAT Cascade Homeostasis Of Number Of Cells Within A Tissue Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Positive Regulation Of Calcium Ion Transport Regulation Of Sensory Perception Of Pain Platelet Dense Granule Organization Positive Regulation Of ERK1 And ERK2 Cascade Thrombin Receptor Signaling Pathway Negative Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Interleukin-8 Secretion Positive Regulation Of Interleukin-6 Secretion	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Signal Transduction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Visual Perception Phototransduction, Visible Light Cell Proliferation Response To Light Stimulus Response To Light Intensity Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Eye Photoreceptor Cell Development Detection Of Light Stimulus Involved In Visual Perception Sensory Perception Of Umami Taste Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Retina Development In Camera-type Eye Cellular Response To Electrical Stimulus
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Formation of Fibrin Clot (Clotting Cascade) Common Pathway G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Platelet activation, signaling and aggregation	Signaling by GPCR PLC beta mediated events Opioid Signalling G-protein mediated events Diseases associated with visual transduction Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade GPCR downstream signaling Visual phototransduction G-protein activation The phototransduction cascade G alpha (i) signalling events
Drugs		Streptokinase
Diseases
GWAS		Mean platelet volume ( 22139419) Platelet counts ( 22139419)
Protein-Protein Interactions		17 interactors: ATP13A2 CAPN1 CHRD CTSG ELANE F2 GNA12 GNA13 GNA15 GNAI2 GNAT1 GPRASP1 ITGAV PDCD6IP PLG PRTN3 SNX1	3 interactors: F2R RGS16 RGS9
Entrez ID		2149	2779
HPRD ID		01763	08850
Ensembl ID		ENSG00000181104
Uniprot IDs		P25116 Q2TNB2	P11488
PDB IDs		1NRN 1NRO 1NRP 1NRQ 1NRR 3BEF 3HKI 3HKJ 3LU9 3VW7	3RBQ
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Platelet Activation Response To Wounding Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Extracellular Matrix Disassembly Positive Regulation Of Cell Proliferation Regulation Of Cell Proliferation Extracellular Matrix Organization Extracellular Structure Organization Cell Activation Killing By Host Of Symbiont Cells Leukocyte Migration Receptor Metabolic Process Negative Regulation Of Fibrinolysis Response To Stress Receptor Catabolic Process Regulation Of Fibrinolysis Proteolysis G-protein Coupled Acetylcholine Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Locomotion Cellular Homeostasis Neutrophil Mediated Immunity Killing Of Cells Of Other Organism Cellular Metal Ion Homeostasis Negative Regulation Of Growth Of Symbiont In Host Defense Response To Fungus Regulation Of Cell Shape Fibrinolysis Cellular Cation Homeostasis Positive Regulation Of Blood Coagulation Cellular Ion Homeostasis Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Interaction With Symbiont Leukocyte Mediated Cytotoxicity Cytosolic Calcium Ion Homeostasis Metal Ion Homeostasis Regulation Of Signal Transduction Positive Regulation Of Coagulation Response To Fungus Regulation Of Protein Metabolic Process Cellular Chemical Homeostasis Response To Stimulus Positive Regulation Of Wound Healing Ion Homeostasis	Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Hydrolase Activity Negative Regulation Of Renin Secretion Into Blood Stream Visual Perception Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Sensory Perception Of Light Stimulus Positive Regulation Of Catalytic Activity Establishment Of Synaptic Specificity At Neuromuscular Junction Connective Tissue Replacement Involved In Inflammatory Response Wound Healing STAT Protein Import Into Nucleus Negative Regulation Of Glomerular Filtration Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Interleukin-6 Secretion Wound Healing Involved In Inflammatory Response Regulation Of Catalytic Activity Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Interleukin-8 Secretion Platelet Dense Granule Organization Thrombin Receptor Signaling Pathway Regulation Of Glomerular Filtration Regulation Of Signal Transduction Regulation Of Interleukin-8 Secretion Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Regulation Of Signaling Positive Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of GTPase Activity Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Collagen Biosynthetic Process Regulation Of Sensory Perception Of Pain Sensory Perception Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Collagen Metabolic Process Response To Lipid Rhodopsin Mediated Signaling Pathway Positive Regulation Of Interleukin-8 Production Positive Regulation Of Vasoconstriction Positive Regulation Of Blood Coagulation Dopamine Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Rho Protein Signal Transduction Regulation Of Collagen Metabolic Process Positive Regulation Of Calcium Ion Transport Into Cytosol Homeostasis Of Number Of Cells Within A Tissue Regulation Of Sequestering Of Calcium Ion Secretory Granule Organization Positive Regulation Of Coagulation
Tagcloud ?		agt card4 casp1 csf2 csf3 curcuma icam1 ifng ikbkb ikbke il10 il1a il1b il8 impressive irak2 longa map3k1 nfkb1 nfkb2 nfkbia ppm1a raf1 relb ticam1 ticam2 tnfalphaip3 tnfrsf7 tnfsf10
Tagcloud (Difference) ?		agt card4 casp1 csf2 csf3 curcuma icam1 ifng ikbkb ikbke il10 il1a il1b il8 impressive irak2 longa map3k1 nfkb1 nfkb2 nfkbia ppm1a raf1 relb ticam1 ticam2 tnfalphaip3 tnfrsf7 tnfsf10
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