DTX2 and TRIM35

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DTX2	TRIM35
Description		deltex E3 ubiquitin ligase 2	tripartite motif containing 35
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Membrane	Nucleus Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Notch Signaling Pathway Protein Ubiquitination	Apoptotic Process Protein Ubiquitination Positive Regulation Of Apoptotic Process Suppression Of Viral Release By Host Innate Immune Response Negative Regulation Of Mitotic Cell Cycle
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus	Interferon gamma signaling
Drugs
Diseases
GWAS			Chronotype ( 30696823) Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Lung cancer ( 28604730)
Interacting Genes		135 interacting genes: ABHD11 ABHD16A ACTMAP ALKBH4 ANAPC11 ANTKMT ARID5A ARMC7 ARNT2 BCL2L11 BICRAL BOLA2-SMG1P6 C10orf55 C1orf94 C22orf39 CCDC57 CFAP68 CIMIP1 CLPP COA6 COQ8A DAZAP2 DOK3 DTX1 DTX3 ECM1 ECSIT EIF4ENIF1 EIF4G1 EYA2 FAM168A FCRL4 FHL2 FHL5 FOXI1 FTO GLYCTK GOLGA2 H3C1 HDC HGS HLX HOXA1 HOXB2 HOXD12 HPCA HPCAL1 HPCAL4 HSFY1 HSFY2 IKZF3 KANK2 KLC3 KLHDC7B KRTAP11-1 KRTAP13-3 KRTAP15-1 KRTAP19-1 KRTAP19-6 KRTAP19-7 KRTAP26-1 KRTAP6-1 KRTAP7-1 KRTAP8-1 LASP1 LNX1 LRP2BP MBD3L1 MDC1 MED19 MSS51 MVP MXRA8 NCALD NCS1 NHLRC4 NIF3L1 NME4 NOTCH1 OIP5 PARP1 PARP10 PAX5 PLEKHF2 PLEKHG4 PLSCR1 POGZ PRR32 PRR34 PSMB4 QARS1 RBM11 RBPMS RFX6 RHOXF2 RIMBP3 RUNX1 RUNX2 RUNX3 RUSC1 SAXO4 SEC22A SEC23A SEC23B SEPSECS SLC67A1-AS SOHLH1 SPAG8 STX12 SUMO1 TBX15 TEKT5 TENT2 TMEM42 TRIB3 TRIM35 TRIM54 TRIP13 TRIP6 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBQLN4 USP54 VGLL3 VSNL1 ZNF34 ZNF503 ZNF620 ZNF641 ZNF764 ZNF774 ZNF85	50 interacting genes: ADIPOQ ANTXR1 BANP CABP2 COL8A1 DTX2 ENKD1 FNDC3B GNMT HNRNPA2B1 IGFN1 KANK2 LCK LMO1 MGAT5B NRF1 PAN2 PARD6B PDCD5 PHF24 PKM PPP2CA PRKAB2 PRR20A PRR20B PRR20C PRR20D PRR20E QARS1 SHC3 SMARCB1 TCEANC TRAPPC6A TRIM10 TRIM11 TRIM5 TRIM55 TRIM63 TSG101 TSSK3 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2K UBE2U UBE2W USP2 USP49 ZNF410
Entrez ID		113878	23087
HPRD ID		16841	15553
Ensembl ID		ENSG00000091073	ENSG00000104228
Uniprot IDs		Q86UW9	E5RGB3 Q9UPQ4
PDB IDs		6IR0 6Y22 6Y2X 6Y3J
Enriched GO Terms of Interacting Partners?		Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Intermediate Filament Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Axonemal A Tubule Inner Sheath Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Ubiquitin Conjugating Enzyme Activity Nucleus Core-binding Factor Complex Apoptotic Process Involved In Embryonic Digit Morphogenesis Chromatin Regulation Of Base-excision Repair Broad Specificity Oxidative DNA Demethylase Activity	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein Polyubiquitination Protein Ubiquitination Protein Modification Process Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Activity Transferase Activity Host-mediated Suppression Of Symbiont Invasion Protein Metabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Host-mediated Perturbation Of Symbiont Process Macromolecule Metabolic Process Modulation Of Process Of Another Organism Protein Binding Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process
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