DTX2 and HDC

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		DTX2	HDC
Description		deltex E3 ubiquitin ligase 2	histidine decarboxylase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Membrane	Cytoplasm Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Histidine Decarboxylase Activity Protein Binding Lyase Activity Carbon-carbon Lyase Activity Carboxy-lyase Activity Pyridoxal Phosphate Binding
	Biological Process	Notch Signaling Pathway Protein Ubiquitination	Histamine Biosynthetic Process Amino Acid Metabolic Process L-histidine Metabolic Process L-histidine Catabolic Process Carboxylic Acid Metabolic Process Biogenic Amine Biosynthetic Process Catecholamine Biosynthetic Process
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus	Histidine catabolism
Drugs			Pyridoxal phosphate Histidine
Diseases			Tourette syndrome
GWAS			Basophil count ( 32888494) Lung function (FEV1/FVC) ( 30061609)
Interacting Genes		135 interacting genes: ABHD11 ABHD16A ACTMAP ALKBH4 ANAPC11 ANTKMT ARID5A ARMC7 ARNT2 BCL2L11 BICRAL BOLA2-SMG1P6 C10orf55 C1orf94 C22orf39 CCDC57 CFAP68 CIMIP1 CLPP COA6 COQ8A DAZAP2 DOK3 DTX1 DTX3 ECM1 ECSIT EIF4ENIF1 EIF4G1 EYA2 FAM168A FCRL4 FHL2 FHL5 FOXI1 FTO GLYCTK GOLGA2 H3C1 HDC HGS HLX HOXA1 HOXB2 HOXD12 HPCA HPCAL1 HPCAL4 HSFY1 HSFY2 IKZF3 KANK2 KLC3 KLHDC7B KRTAP11-1 KRTAP13-3 KRTAP15-1 KRTAP19-1 KRTAP19-6 KRTAP19-7 KRTAP26-1 KRTAP6-1 KRTAP7-1 KRTAP8-1 LASP1 LNX1 LRP2BP MBD3L1 MDC1 MED19 MSS51 MVP MXRA8 NCALD NCS1 NHLRC4 NIF3L1 NME4 NOTCH1 OIP5 PARP1 PARP10 PAX5 PLEKHF2 PLEKHG4 PLSCR1 POGZ PRR32 PRR34 PSMB4 QARS1 RBM11 RBPMS RFX6 RHOXF2 RIMBP3 RUNX1 RUNX2 RUNX3 RUSC1 SAXO4 SEC22A SEC23A SEC23B SEPSECS SLC67A1-AS SOHLH1 SPAG8 STX12 SUMO1 TBX15 TEKT5 TENT2 TMEM42 TRIB3 TRIM35 TRIM54 TRIP13 TRIP6 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBQLN4 USP54 VGLL3 VSNL1 ZNF34 ZNF503 ZNF620 ZNF641 ZNF764 ZNF774 ZNF85	2 interacting genes: DTX2 GZMA
Entrez ID		113878	3067
HPRD ID		16841	00817
Ensembl ID		ENSG00000091073	ENSG00000140287
Uniprot IDs		Q86UW9	P19113
PDB IDs		6IR0 6Y22 6Y2X 6Y3J	4E1O 7EIW 7EIX 7EIY
Enriched GO Terms of Interacting Partners?		Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Intermediate Filament Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Axonemal A Tubule Inner Sheath Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Ubiquitin Conjugating Enzyme Activity Nucleus Core-binding Factor Complex Apoptotic Process Involved In Embryonic Digit Morphogenesis Chromatin Regulation Of Base-excision Repair Broad Specificity Oxidative DNA Demethylase Activity	Negative Regulation Of Deoxyribonuclease Activity Negative Regulation Of Endodeoxyribonuclease Activity Cytotoxic T Cell Pyroptotic Cell Death Negative Regulation Of Nuclease Activity Negative Regulation Of Oxidoreductase Activity Regulation Of Endodeoxyribonuclease Activity Granzyme-mediated Programmed Cell Death Signaling Pathway Negative Regulation Of DNA Binding Pyroptotic Cell Death Regulation Of Oxidoreductase Activity Immunological Synapse Pyroptotic Inflammatory Response Regulation Of DNA Binding
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