DTX2 and PARP10

Number of citations of the paper that reports this interaction (PubMedID 36197986)
66

Data Source:
BioGRID (enzymatic study)

		DTX2	PARP10
Description		deltex E3 ubiquitin ligase 2	poly(ADP-ribose) polymerase family member 10
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Membrane	Nucleus Nucleolus Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Transcription Corepressor Activity NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity K63-linked Polyubiquitin Modification-dependent Protein Binding DNA-binding Transcription Factor Binding NAD+-protein-lysine ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Notch Signaling Pathway Protein Ubiquitination	DNA Repair Chromatin Organization DNA Damage Response Negative Regulation Of Gene Expression Viral Protein Processing Translesion Synthesis Negative Regulation Of NF-kappaB Transcription Factor Activity NAD+ Biosynthetic Process Via The Salvage Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of Fibroblast Proliferation Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Negative Regulation Of Protein K63-linked Ubiquitination
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus	Nicotinate metabolism Maturation of nucleoprotein Maturation of nucleoprotein
Drugs
Diseases
GWAS			Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Hip index ( 34021172) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Red cell distribution width ( 32888494)
Interacting Genes		135 interacting genes: ABHD11 ABHD16A ACTMAP ALKBH4 ANAPC11 ANTKMT ARID5A ARMC7 ARNT2 BCL2L11 BICRAL BOLA2-SMG1P6 C10orf55 C1orf94 C22orf39 CCDC57 CFAP68 CIMIP1 CLPP COA6 COQ8A DAZAP2 DOK3 DTX1 DTX3 ECM1 ECSIT EIF4ENIF1 EIF4G1 EYA2 FAM168A FCRL4 FHL2 FHL5 FOXI1 FTO GLYCTK GOLGA2 H3C1 HDC HGS HLX HOXA1 HOXB2 HOXD12 HPCA HPCAL1 HPCAL4 HSFY1 HSFY2 IKZF3 KANK2 KLC3 KLHDC7B KRTAP11-1 KRTAP13-3 KRTAP15-1 KRTAP19-1 KRTAP19-6 KRTAP19-7 KRTAP26-1 KRTAP6-1 KRTAP7-1 KRTAP8-1 LASP1 LNX1 LRP2BP MBD3L1 MDC1 MED19 MSS51 MVP MXRA8 NCALD NCS1 NHLRC4 NIF3L1 NME4 NOTCH1 OIP5 PARP1 PARP10 PAX5 PLEKHF2 PLEKHG4 PLSCR1 POGZ PRR32 PRR34 PSMB4 QARS1 RBM11 RBPMS RFX6 RHOXF2 RIMBP3 RUNX1 RUNX2 RUNX3 RUSC1 SAXO4 SEC22A SEC23A SEC23B SEPSECS SLC67A1-AS SOHLH1 SPAG8 STX12 SUMO1 TBX15 TEKT5 TENT2 TMEM42 TRIB3 TRIM35 TRIM54 TRIP13 TRIP6 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBQLN4 USP54 VGLL3 VSNL1 ZNF34 ZNF503 ZNF620 ZNF641 ZNF764 ZNF774 ZNF85	14 interacting genes: AURKA DTX2 H2AC20 H2BC21 H3-3A H3C1 H4C1 MYC PARP14 PCNA PLK1 RAN RNF26 UBC
Entrez ID		113878	84875
HPRD ID		16841	15100
Ensembl ID		ENSG00000091073	ENSG00000178685
Uniprot IDs		Q86UW9	B4E0C4 E9PK67 E9PNI7 E9PPE7 Q53GL7
PDB IDs		6IR0 6Y22 6Y2X 6Y3J	2DHX 3HKV 5LX6 6FXI
Enriched GO Terms of Interacting Partners?		Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Intermediate Filament Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Axonemal A Tubule Inner Sheath Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Ubiquitin Conjugating Enzyme Activity Nucleus Core-binding Factor Complex Apoptotic Process Involved In Embryonic Digit Morphogenesis Chromatin Regulation Of Base-excision Repair Broad Specificity Oxidative DNA Demethylase Activity	Chromosome Organization Protein Heterodimerization Activity Structural Constituent Of Chromatin Nucleosome Chromatin Organization Chromatin Remodeling Chromosome Nucleosome Assembly Telomere Organization Nucleosome Organization Protein-DNA Complex Assembly Nucleoplasm Nucleus Organelle Organization Centrosome Separation Epigenetic Regulation Of Gene Expression Mitotic Spindle Organization Extracellular Exosome Microtubule Cytoskeleton Organization Involved In Mitosis Mitotic Cell Cycle Protein Localization To Centrosome Spindle Midzone Mitotic Cell Cycle Phase Transition Protein-containing Complex Liver Regeneration Cell Cycle Phase Transition Spindle Organization Centriole Negative Regulation Of Gene Expression, Epigenetic Chromosome, Telomeric Region Regulation Of Cell Division Post-translational Protein Modification Mitotic Sister Chromatid Segregation Midbody Mitotic Spindle Pole Sister Chromatid Segregation Spindle Microtubule Peptidyl-serine Phosphorylation DNA Binding Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding PCNA Complex Replisome Male Germ Cell Nucleus Protein Localization To Cytoskeleton Centrosome Cycle Protein Localization To Chromatin G2/M Transition Of Mitotic Cell Cycle
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