PNPLA3

Gene Name		patatin-like phospholipase domain containing 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Phospholipase A2 Activity Triglyceride Lipase Activity Mono-olein Transacylation Activity Diolein Transacylation Activity
	Biological Process	Phospholipid Metabolic Process Triglyceride Biosynthetic Process Triglyceride Catabolic Process Acylglycerol Acyl-chain Remodeling Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process
Pathways		Metabolism of lipids and lipoproteins Acyl chain remodeling of DAG and TAG Phospholipid metabolism Glycerophospholipid biosynthesis
Drugs
Diseases
GWAS		Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 22001757) Metabolite levels ( 21909109) Non-alcoholic fatty liver disease ( 23535911) Nonalcoholic fatty liver disease ( 21423719 22719876)
Protein-protein Interactions		2 interactors: AKT2 SNX27
Entrez ID		80339
HPRD ID		12430
Ensembl ID		ENSG00000100344
Uniprot IDs		Q9NST1
PDB IDs
Enriched GO Terms of Interacting Partners?		Establishment Of Natural Killer Cell Polarity Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Activation Of Ral GTPase Activity Positive Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Ral GTPase Activity Regulation Of Ral Protein Signal Transduction Retrograde Transport, Endosome To Plasma Membrane Positive Regulation Of Fatty Acid Beta-oxidation Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Vesicle Fusion Positive Regulation Of Glycogen Biosynthetic Process Peripheral Nervous System Myelin Maintenance Positive Regulation Of Fatty Acid Oxidation Regulation Of Fatty Acid Beta-oxidation Intracellular Protein Transport Mammary Gland Epithelial Cell Differentiation Positive Regulation Of Protein Targeting To Membrane Myelin Maintenance Negative Regulation Of Lipid Transport Positive Regulation Of Lipid Catabolic Process Glycogen Biosynthetic Process Regulation Of Vesicle Fusion Endosome To Lysosome Transport Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Oxidation Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Fatty Acid Transport Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Glucose Import Myelination In Peripheral Nervous System Regulation Of Glycogen Metabolic Process Cellular Polysaccharide Biosynthetic Process Cellular Protein Localization Positive Regulation Of Glucose Transport Schwann Cell Development Intracellular Protein Transmembrane Transport Protein Transport Polysaccharide Biosynthetic Process Lysosomal Transport Activation Of Ras GTPase Activity Establishment Of Protein Localization Negative Regulation Of Ion Transmembrane Transport Intracellular Transport Protein Transmembrane Transport Negative Regulation Of Transmembrane Transport Schwann Cell Differentiation Regulation Of Glucose Import Regulation Of Lipid Catabolic Process Glycogen Metabolic Process Natural Killer Cell Activation
Tagcloud ?		clues depdc5 directions dp dq exome g1896a gwass hbv hepatocarcinogenesis hla hotspots htert integrations kif1b landscape mica mutational pose possibilities rtm204i rtm204v shall technologies threats throughput transitions underlined warrant