PNPLA3 and SNX27

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PNPLA3	SNX27
Description		patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase	sorting nexin 27
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Lipid Droplet Membrane	Immunological Synapse Cytoplasm Endosome Early Endosome Cytosol Membrane Retromer Complex Early Endosome Membrane WASH Complex Schaffer Collateral - CA1 Synapse Postsynapse Postsynaptic Recycling Endosome Postsynaptic Early Endosome Glutamatergic Synapse
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity Lipoprotein Lipase Activity Phospholipase A2 Activity Triacylglycerol Lipase Activity Acylglycerol O-acyltransferase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Lysophosphatidic Acid Binding Long-chain Fatty Acyl-CoA Binding Lysophosphatidic Acid Acyltransferase Activity Mono-olein Transacylation Activity Diolein Transacylation Activity	Protein Binding Lipid Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding
	Biological Process	Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Glycerophospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Phospholipid Biosynthetic Process Response To Sucrose Lipid Catabolic Process Triglyceride Biosynthetic Process Triglyceride Catabolic Process Cellular Response To Insulin Stimulus Lipid Droplet Organization Triglyceride Acyl-chain Remodeling Acylglycerol Acyl-chain Remodeling White Fat Cell Differentiation Lipid Homeostasis Cellular Response To 3,3',5-triiodo-L-thyronine	Establishment Of Natural Killer Cell Polarity Intracellular Protein Transport Signal Transduction Endosome To Lysosome Transport Protein Transport Endosomal Transport Endocytic Recycling Regulation Of Synapse Maturation Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Pathways		Acyl chain remodeling of DAG and TAG
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Alanine aminotransferase levels ( 34315874 33547301 33339817 31219225 30718733) Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Alanine transaminase levels ( 29403010) Alcohol-related hepatocellular carcinoma ( 34902334) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 31219225 34315874 29403010 33547301 33339817) Cirrhosis ( 31815349) Cirrhosis (alcohol related) ( 26482880 32853455) Cirrhosis (multi-trait analysis) ( 33310085) Gout ( 33832965) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494 27863252) Hematological and biochemical traits ( 20139978) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Hepatic lipid content in extreme obesity ( 25246029) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 33972514 22001757) Liver fat content (MRI proton density fat fraction measure) ( 32247823) Liver fibrosis and steatohepatitis severity (MRI cT1 measure) ( 32247823) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular volume ( 32888494 29403010) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 21909109) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Nonalcoholic fatty liver disease ( 29271184 21423719 29385134 24531328 22719876 34841290 32298765 31311600) Nonalcoholic steatohepatitis ( 32298765) Nonalcoholic steatohepatitis-derived hepatocellular carcinoma ( 29385134) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Percent liver fat ( 34128465) Platelet count ( 27863252 29403010 32888494) Plateletcrit ( 32888494 27863252) Red cell distribution width ( 32888494 28957414 27863252) Serum uric acid levels ( 30993211) Total cholesterol levels ( 30275531 33339817 31217584) Total triglycerides levels ( 26690388) Triacylglycerol 56:6 levels ( 31560688) Type 2 diabetes ( 29632382 30297969) Type 2 diabetes (adjusted for BMI) ( 29632382) Urate levels ( 31578528)	Body mass index ( 26426971)
Interacting Genes		3 interacting genes: AKT2 LINC00839 SNX27	16 interacting genes: ACE2 ACVR2B APP BRSK2 CDK16 DGKZ ERBB4 HLCS PDGFRB PNPLA3 PTEN RPS6KA1 SELP SUMO2 UBC VANGL2
Entrez ID		80339	81609
HPRD ID		12430	11591
Ensembl ID		ENSG00000100344	ENSG00000143376
Uniprot IDs		Q9NST1	A0A2R8Y8A7 Q96L92
PDB IDs			4HAS 5ZN9 6SAK 7CT1 7E0B 7P72 7PCB 8TTT 8TTU 8TTV
Enriched GO Terms of Interacting Partners?		Early Endosome Cellular Response To High Light Intensity Positive Regulation Of Cytoplasmic Translational Initiation Response To High Light Intensity Positive Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Retinal Cell Apoptotic Process Positive Regulation Of Cap-dependent Translational Initiation Retinal Rod Cell Apoptotic Process Peripheral Nervous System Myelin Maintenance Vascular Endothelial Growth Factor Receptor Activity Common Myeloid Progenitor Cell Proliferation Pro-B Cell Differentiation Myeloid Progenitor Cell Differentiation Phosphatidylinositol 3-kinase Activator Activity Postsynaptic Recycling Endosome Establishment Of Natural Killer Cell Polarity Postsynaptic Early Endosome Cellular Response To Hormone Stimulus Negative Regulation Of PERK-mediated Unfolded Protein Response Lymphoid Progenitor Cell Differentiation Regulation Of Fatty Acid Beta-oxidation Myelin Maintenance Mammary Gland Epithelial Cell Differentiation Response To Light Intensity Positive Regulation Of Glycogen Biosynthetic Process Regulation Of PERK-mediated Unfolded Protein Response Glycogen Biosynthetic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Fatty Acid Oxidation Nuclear Glucocorticoid Receptor Binding WASH Complex Vascular Endothelial Growth Factor Signaling Pathway Protein Kinase Activity Localization Within Membrane Polysaccharide Biosynthetic Process Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Retromer Complex Molecular Function Activator Activity Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Lipid Catabolic Process Positive Regulation Of Protein Targeting To Membrane Regulation Of Synapse Maturation Regulation Of Glycogen Biosynthetic Process Liver Regeneration Regulation Of Protein Targeting To Membrane Kinase Activity	Kinase Activity Protein Metabolic Process Phosphorylation Regulation Of Cell Communication Protein Kinase Activity Regulation Of Signaling Protein Modification Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Migration Phosphate-containing Compound Metabolic Process Protein Phosphorylation Regulation Of Synaptic Vesicle Clustering ATP Binding Cell Motility Receptor Complex Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Nucleotide Binding Transferase Activity Regulation Of Signal Transduction Retina Vasculature Development In Camera-type Eye Protein Tag Activity Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Macromolecule Metabolic Process Response To Growth Factor Anatomical Structure Morphogenesis Establishment Of Planar Polarity System Development Regulation Of Reactive Oxygen Species Metabolic Process Phosphatidic Acid Biosynthetic Process Protein Serine/threonine/tyrosine Kinase Activity Apical Plasma Membrane Regulation Of Smooth Muscle Cell Proliferation Axonogenesis Protein Serine/threonine Kinase Activity Enzyme Binding Positive Regulation Of Excitatory Postsynaptic Potential Reproductive Behavior Phosphatidic Acid Metabolic Process Plasma Membrane Glycerophospholipid Biosynthetic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Proteolysis Amyloid-beta Complex Regulation Of Cellular Component Organization Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Response To Calcium Ion
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