ERH and SH3GL2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ERH	SH3GL2
Gene Name		enhancer of rudimentary homolog (Drosophila)	SH3-domain GRB2-like 2
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Gene Ontology Annotations	Cellular Component	Membrane Midbody	Golgi Membrane Cytosol Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Poly(A) RNA Binding	Protein Binding Lipid Binding Identical Protein Binding
	Biological Process	Osteoblast Differentiation Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleoside Metabolic Process Cell Cycle	Regulation Of Receptor Internalization Post-Golgi Vesicle-mediated Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Central Nervous System Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Synaptic Vesicle Endocytosis Membrane Organization
Pathways			Retrograde neurotrophin signalling EGFR downregulation Signalling by NGF Axon guidance Golgi Associated Vesicle Biogenesis L1CAM interactions Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Recycling pathway of L1 Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Signaling by EGFR MHC class II antigen presentation Signaling by EGFR in Cancer trans-Golgi Network Vesicle Budding Adaptive Immune System
Drugs
Diseases
GWAS			Cognitive performance ( 19734545) Heart failure ( 20445134) Multiple sclerosis ( 19010793) Obesity-related traits ( 23251661) Parkinson's disease ( 22451204)
Protein-Protein Interactions		19 interactors: APP CHTOP CIZ1 COPS6 CSNK2A1 CSNK2A2 CTDP1 FAM208B HSPA8 IGSF21 MED31 POLDIP3 RBM48 RPS6KA5 SETDB1 SH3GL2 TLE1 TP53 UNC119	53 interactors: ACTG1 ADAM15 ADAM19 ADRB1 AMPH APP ARNT2 ATXN2 BIN1 CD2AP CLEC3B DACT1 DLGAP4 DNM1 DNM2 DPPA4 DPYSL4 EGFL6 EMD ERH F13A1 GCH1 GSTM3 HLA-DQA1 IGHM IL6 ITCH ITSN1 LCP2 LRRK2 MAP4K3 MAST2 PAK2 PAXIP1 PDCD6IP PPP1R21 PPP6R1 PRR14 SH3GL1 SH3GL3 SH3KBP1 SLC17A7 SYN1 SYNJ1 SYNJ2 TCEA2 TERF1 TIAM2 TMEM108 TYMS ZNF219 ZNF580 ZXDC
Entrez ID		2079	6456
HPRD ID		09026	05125
Ensembl ID			ENSG00000107295
Uniprot IDs		P84090	B7Z7W3 F5H5J3 Q7Z376 Q8IZ09 Q99962
PDB IDs		1W9G 2NML	1X03 1X04 2D4C 2DBM
Enriched GO Terms of Interacting Partners?		Axon Guidance Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Axonogenesis Positive Regulation Of Metabolic Process Axon Development Gene Expression Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Transcription, DNA-templated Regulation Of Gene Expression Cell Morphogenesis Involved In Differentiation RNA Biosynthetic Process RNA Metabolic Process Response To External Stimulus Regulation Of Chromosome Organization Neuron Projection Development Cell Projection Morphogenesis Regulation Of Mitotic Cell Cycle Phase Transition Cell Part Morphogenesis Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Phase Transition Regulation Of RNA Metabolic Process Neuron Development Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Generation Of Neurons Cell Morphogenesis Neurogenesis Neuron Differentiation Mitotic Cell Cycle Process Cell Projection Organization Anatomical Structure Morphogenesis Positive Regulation Of Protein Metabolic Process Regulation Of Transcription, DNA-templated Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Locomotion Regulation Of Nucleic Acid-templated Transcription Notch Signaling Pathway Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Checkpoint Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process	Endocytosis Developmental Process Neuron Projection Morphogenesis Neuron Projection Development Vesicle-mediated Transport Signaling Locomotion Cell Communication Cell Differentiation Cell-cell Signaling System Development Cell Projection Organization Positive Regulation Of Programmed Cell Death Neuron Development Positive Regulation Of Cell Death Response To Stimulus Cell Projection Morphogenesis Multicellular Organismal Development Cell Morphogenesis Cell Part Morphogenesis Nervous System Development Cell Development Neuron Differentiation Synaptic Transmission Positive Regulation Of Apoptotic Process Regulation Of Cellular Component Organization Chemotaxis Innate Immune Response Anatomical Structure Development Cell Death Platelet Activation Death Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Generation Of Neurons Response To External Stimulus Defense Response Synaptic Vesicle Transport Secretion By Cell Cellular Response To Stimulus Regulation Of Synaptic Vesicle Transport Positive Regulation Of Metabolic Process Cell Morphogenesis Involved In Differentiation Neurogenesis Regulation Of Vesicle-mediated Transport Response To Stress Signal Transduction Axon Guidance Apoptotic Process Regulation Of Apoptotic Process
Tagcloud ?		ambient avoid centre cereal decreasing equilibrium exceeding generates grain grains heating humidity infestation insect kept liable loading minimised moisture mould parts periphery shipboard shipment storage stow temperature temperatures threshold	250k 9p22 affymetrix alteration array biopsies corresponding deleted evident forced heterozygosity informative interactor internalization invasion modulating mucosal nsclc nspi paired platform scanning ser ss transfected tyr understand usp9x validation
Tagcloud (Difference) ?		ambient avoid centre cereal decreasing equilibrium exceeding generates grain grains heating humidity infestation insect kept liable loading minimised moisture mould parts periphery shipboard shipment storage stow temperature temperatures threshold	250k 9p22 affymetrix alteration array biopsies corresponding deleted evident forced heterozygosity informative interactor internalization invasion modulating mucosal nsclc nspi paired platform scanning ser ss transfected tyr understand usp9x validation
Tagcloud (Intersection) ?